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• • ·Table of Contents

    Page :i

    
• • ·Editorial Board

    Page :iii

    
• • ·Information for Readers

    Page :v

    

• Editorials

  • ·Predicting heart failure in atrial fibrillation patients: What about using biomarkers?

    Page :32-34

    Raquel López-Gálvez, Francisco Marín, José Miguel Rivera-Caravaca

    Plan Plan

• Trial Designs

  • ·The efficacy of single-lead implantable cardioverter-defibrillator with atrial sensing dipole to detect atrial fibrillation and to reduce inappropriate therapy according to atrial sensing ON or OFF: Rationale and design of the SMART-CONTROL study, a prospective multicenter randomized trial

    Page :25-31

    Hye Bin Gwag, Hye Ree Kim, Seung-Jung Park, Juwon Kim, Tae Wan Chung, Ji-Hoon Choi, Ju Youn Kim, Kyoung-Min Park, Young Keun On, June Soo Kim

    Résumé Résumé Plan Plan   
  • ·Comparison of anticoagulation with left atrial appendage closure after atrial fibrillation ablation: Rationale and design of the OPTION randomized trial

    Page :35-42

    Oussama M. Wazni, Lucas Boersma, Jeff S. Healey, Moussa Mansour, Claudio Tondo, Karen Phillips, Rahul Doshi, Wael Jaber, Erin Hynes, Dominic J. Allocco, Vivek Y. Reddy

    Résumé Résumé Plan Plan  
  • ·Ultrasound-facilitated, catheter-directed thrombolysis vs anticoagulation alone for acute intermediate-high-risk pulmonary embolism: Rationale and design of the HI-PEITHO study

    Page :43-53

    Frederikus A. Klok, Gregory Piazza, Andrew S.P. Sharp, Fionnuala Ní Ainle, Michael R. Jaff, Nikhil Chauhan, Binal Patel, Stefano Barco, Samuel Z. Goldhaber, Nils Kucher, Irene M. Lang, Irene Schmidtmann, Keith M. Sterling, Dorothea Becker, Nadine Martin, Kenneth Rosenfield, Stavros V. Konstantinides

    Résumé Résumé Plan Plan  
  • ·A randomized multicenter trial to evaluate early invasive strategy for patients with acute ST-segment elevation myocardial infarction presenting 24-48 hours from symptom onset: Protocol of the RESCUE-MI study

    Page :54-60

    Wei Gao, Xin Zhong, Yuanji Ma, Dong Huang, Ruochen Wang, Shihai Zhao, Shan Yang, Juying Qian, Junbo Ge

    Résumé Résumé Plan Plan  
  • ·Study design and rationale for the Olpasiran trials of Cardiovascular Events And lipoproteiN(a) reduction-DOSE finding study (OCEAN(a)-DOSE)

    Page :61-69

    Michelle L. O'Donoghue, J. Antonio G．  López, Beat Knusel, Baris Gencer, Huei Wang, You Wu, Helina Kassahun, Marc S. Sabatine

    Résumé Résumé Plan Plan  
  • ·Rationale and design of switch Swedeheart: A registry-based, stepped-wedge, cluster-randomized, open-label multicenter trial to compare prasugrel and ticagrelor for treatment of patients with acute coronary syndrome

    Page :70-77

    Elmir Omerovic, David Erlinge, Sasha Koul, Ole Frobert, Jonas Andersson, Johan Ponten, Fredrik Björklund, Robert Kastberg, Max Petzold, Charlotta Ljungman, Kristian Bolin, Björn Redfors

    Résumé Résumé Plan Plan   
  • ·Contemporary outpatient management of patients with worsening heart failure with reduced ejection fraction: Rationale and design of the CHART-HF study

    Page :127-136

    Stephen J. Greene, Dominik Lautsch, Hanna K. Gaggin, Laurence M. Djatche, Mo Zhou, Yan Song, James Signorovitch, Andra S. Stevenson, Robert O. Blaustein, Javed Butler

    Résumé Résumé Plan Plan  

• Clinical Investigations

  • ·Morphine and clinical outcomes in patients with ST segment elevation myocardial infarction treated with fibrinolytic and antiplatelet therapy: Insights from the TREAT trial

    Page :1-12

    Warren J. Cantor, Mary Tan, Otavio Berwanger, Shahar Lavi, Harvey D. White, Jose C. Nicolau, Payam Dehghani, Carlos D. Tajer, Renato D. Lopes, Diogo D.F. Moia, Stephen J. Nicholls, Alexander Parkhomenko, Oleg Averkov, Neil Brass, Sohrab Lutchmedial, Germán Malaga, Lucas P. Damiani, Leopoldo S. Piegas, Christopher B. Granger, Shaun G. Goodman

    Résumé Résumé Plan Plan   
  • ·Biomarkers and heart failure events in patients with atrial fibrillation in the ARISTOTLE trial evaluated by a multi-state model

    Page :13-24

    Julia Aulin, Ziad Hijazi, Johan Lindbäck, John H. Alexander, Bernard J. Gersh, Christopher B. Granger, Michael Hanna, John Horowitz, Renato D. Lopes, John J.V. McMurray, Jonas Oldgren, Agneta Siegbahn, Lars Wallentin, ARISTOTLE Investigators

    Résumé Résumé Plan Plan   
  • ·Lipid-lowering treatment intensity, persistence, adherence and goal attainment in patients with coronary heart disease

    Page :78-90

    Faizan Mazhar, Paul Hjemdahl, Catherine M Clase, Kristina Johnell, Tomas Jernberg, Juan Jesus Carrero

    Résumé Résumé Plan Plan   
  • ·Longer term benefits of exercise and escitalopram in the treatment of anxiety in patients with coronary heart disease: Six month follow-up of the UNWIND randomized clinical trial

    Page :91-100

    James A. Blumenthal, Patrick J. Smith, Wei Jiang, Alan Hinderliter, Lana L. Watkins, Benson M. Hoffman, William E. Kraus, Stephanie Mabe, Lawrence Liao, Jonathan Davidson, Andrew Sherwood

    Résumé Résumé Plan Plan  
  • ·Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis

    Page :101-114

    Dae Yong Park, Peter Wang, Seokyung An, Alyssa A. Grimshaw, Jennifer Frampton, E Magnus Ohman, Sunil V. Rao, Michael G. Nanna

    Résumé Résumé Plan Plan   
  • ·Titration of medical therapy and clinical outcomes among patients with heart failure with reduced ejection fraction: Findings from the HF-ACTION trial

    Page :115-126

    Jacob B. Pierce, Robert J. Mentz, Jie-Lena Sun, Brooke Alhanti, David J. Whellan, William E. Kraus, Ileana L. Piña, Mona Fiuzat, Christopher M. O'Connor, Stephen J. Greene

    Résumé Résumé Plan Plan