Sommaire

• • ·Table of Contents

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• • ·Editorial Board

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• • ·Information for Readers

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• Editorials

  • ·When academic research organizations and clinical research organizations disagree: Processes to minimize discrepancies prior to unblinding of randomized trials

    Page :1-8

    C. Michael Gibson, Samuel Z. Goldhaber, Alexander T. Cohen, Tarek Nafee, Adrian F. Hernandez, Russell Hull, Serge Korjian, Yazan Daaboul, Gerald Chi, Megan Yee, Robert A. Harrington

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• Trial Designs

  • ·The sessment of the Wtchman Device in atients Unsuiable fr ral Anticoagulation (ASAP-TOO) trial

    Page :68-74

    David R. Holmes, Vivek Y. Reddy, Maurice Buchbinder, Kenneth Stein, Myriah Elletson, Martin W. Bergmann, Boris Schmidt, Jacqueline Saw

    Résumé Résumé Plan Plan  
  • ·Design and rationale for the nfluenza vaccination fter yocardial nfarction (IAMI) trial. A registry-based randomized clinical trial

    Page :94-102

    Ole Fröbert, Matthias Götberg, Oskar Angerås, Lena Jonasson, David Erlinge, Thomas Engstrøm, Jonas Persson, Svend E. Jensen, Elmir Omerovic, Stefan K. James, Bo Lagerqvist, Johan Nilsson, Amra Kåregren, Rasmus Moer, Cao Yang, David B. Agus, Andrejs Erglis, Lisette O. Jensen, Lars Jakobsen, Evald H. Christiansen, John Pernow

    Résumé Résumé Plan Plan   
  • ·Feasibility of transcatheter aortic valve replacement in low-risk patients with symptomatic severe aortic stenosis: Rationale and design of the Low Risk TAVR (LRT) study

    Page :103-109

    Toby Rogers, Rebecca Torguson, Roshni Bastian, Paul Corso, Ron Waksman

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  • ·Effect of aspirin on renal disease progression in patients with type 2 diabetes: A multicenter, double-blind, placebo-controlled, randomized trial. The renaL disEase progression by aspirin in diabetic pAtients (LEDA) trial. Rationale and study design

    Page :120-127

    Francesco Violi, Giovanni Targher, Annarita Vestri, Roberto Carnevale, Maurizio Averna, Alessio Farcomeni, Andrea Lenzi, Francesco Angelico, Francesco Cipollone, Daniele Pastori

    Résumé Résumé Plan Plan  
  • ·Rationale and design of the Hunting for the off-target propertIes of Ticagrelor on Endothelial function and other Circulating biomarkers in Humans (HI-TECH) trial

    Page :128-136

    Sara Ariotti, Maarten van Leeuwen, Salvatore Brugaletta, Sergio Leonardi, Kristiaan Martijn Akkerhuis, Emrush Rexhaj, Gladys Janssens, Luis Ortega-Paz, Diego Rizzotti, Jan C. van den Berge, Dierik Heg, Gloria Francolini, Stephan Windecker, Marco Valgimigli, The HI-TECH Investigators

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  • ·Rationale and design of the Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation (ARTESiA) trial

    Page :137-145

    Renato D. Lopes, Marco Alings, Stuart J. Connolly, Heather Beresh, Christopher B. Granger, Juan Benezet Mazuecos, Giuseppe Boriani, Jens C. Nielsen, David Conen, Stefan H. Hohnloser, Georges H. Mairesse, Philippe Mabo, A. John Camm, Jeffrey S. Healey

    Résumé Résumé Plan Plan  
  • ·Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol

    Page :158-166

    Valentina Kutyifa, Christopher Beck, Mary W. Brown, David Cannom, James Daubert, Mark Estes, Henry Greenberg, Ilan Goldenberg, Stephen Hammes, David Huang, Helmut Klein, Reinoud Knops, Mikhail Kosiborod, Jeanne Poole, Claudio Schuger, Jagmeet P. Singh, Scott Solomon, David Wilber, Wojciech Zareba, Arthur J. Moss, On behalf of the MADIT S-ICD Executive Committee

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  • ·Change the management of patients with heart failure: Rationale and design of the CHAMP-HF registry

    Page :177-183

    Adam D. DeVore, Laine Thomas, Nancy M. Albert, Javed Butler, Adrian F. Hernandez, J. Herbert Patterson, John A. Spertus, Fredonia B. Williams, Stuart J. Turner, Wing W. Chan, Carol I. Duffy, Kevin McCague, Xiaojuan Mi, Gregg C. Fonarow

    Résumé Résumé Plan Plan  

• Clinical Investigations

  • ·Hemodynamic determinants of mortality after Fontan operation

    Page :9-18

    Hideo Ohuchi, Aya Miyazaki, Jun Negishi, Yosuke Hayama, Michikazu Nakai, Kunihiro Nishimura, Hajime Ichikawa, Isao Shiraishi, Osamu Yamada

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  • ·Electrocardiographic abnormalities and mortality in aging survivors of childhood cancer: A report from the St Jude Lifetime Cohort Study

    Page :19-27

    Daniel A. Mulrooney, Elsayed Z. Soliman, Matthew J. Ehrhardt, Lu Lu, Daniel A. Duprez, Russell V. Luepker, Gregory T. Armstrong, Vijaya M. Joshi, Daniel M. Green, Deokumar Srivastava, Matthew J. Krasin, G. Stephen Morris, Leslie L. Robison, Melissa M. Hudson, Kirsten K. Ness

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  • ·Reliability of updated left ventricular diastolic function recommendations in predicting elevated left ventricular filling pressure and prognosis

    Page :28-39

    Kimi Sato, Andrew D.M. Grant, Kazuaki Negishi, Paul C. Cremer, Tomoko Negishi, Arnav Kumar, Patrick Collier, Samir R. Kapadia, Richard A. Grimm, Milind Y. Desai, Brian P. Griffin, Zoran B. Popovi?

    Résumé Résumé Plan Plan  
  • ·Factors associated with non–vitamin K antagonist oral anticoagulants for stroke prevention in patients with new-onset atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II)

    Page :40-47

    Benjamin A. Steinberg, Peter Shrader, Laine Thomas, Jack Ansell, Gregg C. Fonarow, Bernard J. Gersh, Elaine Hylek, Peter R. Kowey, Kenneth W. Mahaffey, Emily C. O'Brien, Daniel E. Singer, Eric D. Peterson, Jonathan P. Piccini, Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Investigators and Patients

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  • ·Utilization of cardiac resynchronization therapy in eligible patients hospitalized for heart failure and its association with patient outcomes

    Page :48-58

    Tiffany C. Randolph, Anne S. Hellkamp, Emily P. Zeitler, Gregg C. Fonarow, Adrian F. Hernandez, Kevin L. Thomas, Eric D. Peterson, Clyde W. Yancy, Sana M. Al-Khatib

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  • ·Impact of continuous positive airway pressure and oxygen on health status in patients with coronary heart disease, cardiovascular risk factors, and obstructive sleep apnea: A Heart Biomarker Evaluation in Apnea Treatment (HEARTBEAT) analysis

    Page :59-67

    Eldrin F. Lewis, Rui Wang, Naresh Punjabi, Daniel J. Gottlieb, Stuart F. Quan, Deepak L. Bhatt, Sanjay R. Patel, Reena Mehra, Roger S. Blumenthal, Jia Weng, Michael Rueschman, Susan Redline

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  • ·Effects of implantable cardioverter/defibrillator shock and antitachycardia pacing on anxiety and quality of life: A MADIT-RIT substudy

    Page :75-84

    Alessandro Paoletti Perini, Valentina Kutyifa, Peter Veazie, James P. Daubert, Claudio Schuger, Wojciech Zareba, Scott McNitt, Spencer Rosero, Christine Tompkins, Luigi Padeletti, Arthur J. Moss

    Résumé Résumé Plan Plan  
  • ·Seasonal and circadian variations of acute myocardial infarction: Findings from the Get With The Guidelines–Coronary Artery Disease (GWTG-CAD) program

    Page :85-93

    Vijaiganesh Nagarajan, Gregg C. Fonarow, Christine Ju, Michael Pencina, Warren K. Laskey, Thomas M. Maddox, Adrian Hernandez, Deepak L. Bhatt

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  • ·Impact of AHA’s 2007 guideline change on incidence of infective endocarditis in infants and children

    Page :110-119

    Rie Sakai Bizmark, Ruey-Kang R. Chang, Yusuke Tsugawa, Kenneth M. Zangwill, Ichiro Kawachi

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  • ·Cardiovascular events and hospital resource utilization pre– and post–transcatheter mitral valve repair in high–surgical risk patients

    Page :146-157

    Sreekanth Vemulapalli, Steven J. Lippmann, Mitchell Krucoff, Adrian F. Hernandez, Lesley H. Curtis, Elyse Foster, Atif Qasim, Andrew Wang, Donald D. Glower, Ted Feldman, Bradley G. Hammill

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  • ·High-risk echocardiographic features predict mortality in pulmonary arterial hypertension

    Page :167-176

    Christopher Austin, Charles Burger, Garvan Kane, Robert Safford, Joseph Blackshear, Ryan Ung, Jordan Ray, Ali Alsaad, Khadija Alassas, Brian Shapiro

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  • ·Decline in peak oxygen consumption over time predicts death or transplantation in adults with a Fontan circulation

    Page :184-192

    Jonathan W. Cunningham, Ashwin S. Nathan, Jonathan Rhodes, Keri Shafer, Michael J. Landzberg, Alexander R. Opotowsky

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  • ·One-year mortality outcomes and hospital readmissions of patients admitted with acute heart failure: Data from the Trivandrum Heart Failure Registry in Kerala, India

    Page :193-199

    Sivadasanpillai Harikrishnan, Ganapathi Sanjay, Anubha Agarwal, N. Pratap Kumar, K. Krishna Kumar, Charantharayil Gopalan Bahuleyan, Govindan Vijayaraghavan, Sunitha Viswanathan, Madhu Sreedharan, R. Biju, N. Rajalekshmi, Tiny Nair, Krishnan Suresh, Panniyammakal Jeemon

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• Research Letters

  • ·The economics of PCSK-9 inhibitors

    Page :200-201

    Kevin A. Schulman, Shelby D. Reed