Sommaire

• • ·Table of Contents

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• • ·Editorial Board

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• • ·Information for Readers

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• Editorials

  • ·Clinical outcomes trials and the cardiovascular effects of thiazolidinediones: Implications for the evaluation of antidiabetic drugs

    Page :1-2

    Hertzel C. Gerstein, Salim Yusuf

    Plan Plan
  • ·The coin toss: Implications for risk stratification for sudden cardiac death

    Page :3-7

    Jeffrey J. Goldberger

    Résumé Résumé  

• Curriculum in Cardiology

  • ·Leveraging observational registries to inform comparative effectiveness research

    Page :8-15

    Bimal R. Shah, Joseph Drozda, Eric D. Peterson

    Résumé Résumé Plan Plan  

• Trial Design

  • ·Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non–ST-segment elevation myocardial infarction: The TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial

    Page :16

    Chee Tang Chin, Matthew T. Roe, Keith A.A. Fox, Dorairaj Prabhakaran, Debra A. Marshall, Helene Petitjean, Yuliya Lokhnygina, Eileen Brown, Paul W. Armstrong, Harvey D. White, E. Magnus Ohman, on behalf of the TRILOGY ACS Steering Committee

    Résumé Résumé Plan Plan  
  • ·The EVEREST II Trial: Design and rationale for a randomized study of the evalve mitraclip system compared with mitral valve surgery for mitral regurgitation

    Page :23-29

    Laura Mauri, Pallav Garg, Joseph M. Massaro, Elyse Foster, Donald Glower, Paul Mehoudar, Ferolyn Powell, Jan Komtebedde, Elizabeth McDermott, Ted Feldman

    Résumé Résumé Plan Plan  
  • ·The Strategic Reperfusion Early After Myocardial Infarction (STREAM) study

    Page :30

    Paul W. Armstrong, Anthony Gershlick, Patrick Goldstein, Robert Wilcox, Thierry Danays, Erich Bluhmki, Frans Van de Werf, on behalf of the STREAM Steering Committee h

    Résumé Résumé Plan Plan  
  • ·Cryptogenic Stroke and underlying Atrial Fibrillation (CRYSTAL AF): Design and rationale

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    Anil-Martin Sinha, Hans-Christoph Diener, Carlos A. Morillo, Tommaso Sanna, Richard A. Bernstein, Vincenzo Di Lazzaro, Rod Passman, Frank Beckers, Johannes Brachmann

    Résumé Résumé Plan Plan  
  • ·The MOnitoring Resynchronization dEvices and CARdiac patiEnts (MORE-CARE) study: Rationale and design

    Page :42-48

    Haran Burri, Aurelio Quesada, Renato Pietro Ricci, Giuseppe Boriani, Mario Davinelli, Stefano Favale, Antoine Da Costa, Josef Kautzner, Raymond Moser, Xavier Navarro, Massimo Santini

    Résumé Résumé Plan Plan  
  • ·The BioImage Study: Novel approaches to risk assessment in the primary prevention of atherosclerotic cardiovascular disease—study design and objectives

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    Pieter Muntendam, Carol McCall, Javier Sanz, Erling Falk, Valentin Fuster, for the High-Risk Plaque Initiative f

    Résumé Résumé Plan Plan  
  • ·Cell-based therapy for myocardial repair in patients with acute myocardial infarction: Rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction (SWISS-AMI)

    Page :58-64

    Daniel Sürder, Jürg Schwitter, Tiziano Moccetti, Giuseppe Astori, Kaspar Rufibach, Sven Plein, Viviana Lo Cicero, Sabrina Soncin, Stephan Windecker, Aris Moschovitis, Andreas Wahl, Paul Erne, Peiman Jamshidi, Christoph Auf der Maur, Robert Manka, Gianni Soldati, Ines Bühler, Christophe Wyss, Ulf Landmesser, Thomas F. Lüscher, Roberto Corti

    Résumé Résumé Plan Plan  
  • ·Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y₁₂-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI)

    Page :65-72

    Sergio Leonardi, Sunil V. Rao, Robert A. Harrington, Deepak L. Bhatt, C. Michael Gibson, Matthew T. Roe, Janusz Kochman, Kurt Huber, Uwe Zeymer, Mina Madan, Daniel D. Gretler, Matthew W. McClure, Gayle E. Paynter, Vivian Thompson, Robert C. Welsh

    Résumé Résumé Plan Plan  

• Clinical Investigations

  • ·Left ventricular function in acute myocardial infarction treated with thrombolysis followed by early versus late invasive strategy

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    Nisha Mistry, Ellen Bøhmer, Pavel Hoffmann, Carl Müller, Reidar Bjørnerheim, Sverre E. Kjeldsen, Sigrun Halvorsen

    Résumé Résumé Plan Plan  
  • ·Gender differences in time to presentation for myocardial infarction before and after a national women's cardiovascular awareness campaign: A temporal analysis from the Can Rapid Risk Stratification of Unstable Angina Patients Suppress ADverse Outcomes with Early Implementation (CRUSADE) and the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network–Get with the Guidelines (NCDR ACTION Registry–GWTG)

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    Deborah B. Diercks, Kelly P. Owen, Michael C. Kontos, Andra Blomkalns, Anita Y. Chen, Chadwick Miller, Stephen Wiviott, Eric D. Peterson

    Résumé Résumé Plan Plan  
  • ·Improving long-term risk prediction in patients with acute chest pain: The Global Registry of Acute Coronary Events (GRACE) risk score is enhanced by selected nonnecrosis biomarkers

    Page :88-94

    Kai M. Eggers, Tibor Kempf, Per Venge, Lars Wallentin, Kai C. Wollert, Bertil Lindahl

    Résumé Résumé Plan Plan  
  • ·Chronic obstructive pulmonary disease after myocardial infarction in the community

    Page :95-101

    Francesca Bursi, Robert Vassallo, Susan A. Weston, Jill M. Killian, Véronique L. Roger

    Résumé Résumé Plan Plan  
  • ·The impact of combined health factors on cardiovascular disease mortality

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    Jonathan A. Mitchell, Daniel B. Bornstein, Xuemei Sui, Steven P. Hooker, Timothy S. Church, Chong D. Lee, Duck-chul Lee, Steven N. Blair

    Résumé Résumé Plan Plan
  • ·Validity of the LaFarge equation for estimation of oxygen consumption in ventilated children with congenital heart disease younger than 3 years—A revisit

    Page :109-114

    Jennifer Rutledge, Andrew Bush, Lara Shekerdemian, Ingram Schulze-Neick, Daniel Penny, Sally Cai, Jia Li

    Résumé Résumé Plan Plan  
  • ·Beyond insurance coverage: Usual source of care in the treatment of hypertension and hypercholesterolemia. Data from the 2003-2006 National Health and Nutrition Examination Survey

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    Erica S. Spatz, Joseph S. Ross, Mayur M. Desai, Maureen E. Canavan, Harlan M. Krumholz

    Résumé Résumé Plan Plan
  • ·Cost-effectiveness of implantable cardioverter defibrillators in patients ?65 years of age

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    Gillian D. Sanders, Melissa H. Kong, Sana M. Al-Khatib, Eric D. Peterson

    Résumé Résumé Plan Plan  
  • ·Associations between worsening renal function and 30-day outcomes among Medicare beneficiaries hospitalized with heart failure

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    Uptal D. Patel, Melissa A. Greiner, Gregg C. Fonarow, Hemant Phatak, Adrian F. Hernandez, Lesley H. Curtis

    Résumé Résumé Plan Plan
  • ·Hospice, opiates, and acute care service use among the elderly before death from heart failure or cancer

    Page :139-144

    Soko Setoguchi, Robert J. Glynn, Margaret Stedman, Carol M. Flavell, Raisa Levin, Lynne Warner Stevenson

    Résumé Résumé Plan Plan  
  • ·Fatal myocardial rupture after acute myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: The VALsartan In Acute myocardial iNfarcTion Trial (VALIANT)

    Page :145-151

    Faisal Shamshad, Satish Kenchaiah, Peter V. Finn, Jordi Soler-Soler, John J.V. McMurray, Eric J. Velazquez, Aldo P. Maggioni, Robert M. Califf, Karl Swedberg, Lars Kober, Yuri Belenkov, Sergei Varshavsky, Marc A. Pfeffer, Scott D. Solomon, for the VALsartan In Acute myocardial iNfarcTion (VALIANT) Trial Investigators

    Résumé Résumé Plan Plan  
  • ·Race/ethnic disparities in left ventricular diastolic function in a triethnic community cohort

    Page :152-158

    Cesare Russo, Zhezhen Jin, Shunichi Homma, Tatjana Rundek, Mitchell S.V. Elkind, Ralph L. Sacco, Marco R. Di Tullio

    Résumé Résumé Plan Plan
  • ·The Medicare drug benefit (Part D) and treatment of heart failure in older adults

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    Julie M. Donohue, Yuting Zhang, Judith R. Lave, Walid F. Gellad, Aiju Men, Subashan Perera, Joseph T. Hanlon

    Résumé Résumé Plan Plan
  • ·Fitness, fatness, and systolic blood pressure: Data from the Cooper Center Longitudinal Study

    Page :166-170

    Jennifer Chen, Sandeep Das, Carolyn E. Barlow, Scott Grundy, Susan G. Lakoski

    Résumé Résumé Plan Plan  
  • ·LOWERing the INtensity of oral anticoaGulant Therapy in patients with bileaflet mechanical aortic valve replacement: Results from the “LOWERING-IT” Trial

    Page :171-178

    Michele Torella, Daniele Torella, Paolo Chiodini, Marco Franciulli, Giampaolo Romano, Luca De Santo, Marisa De Feo, Cristiano Amarelli, Ferdinando C. Sasso, Teresa Salvatore, Georgina M. Ellison, Ciro Indolfi, Maurizio Cotrufo, Gianantonio Nappi

    Résumé Résumé Plan Plan  
  • ·Effectiveness of recanalization of chronic total occlusions: A systematic review and meta-analysis

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    Dominique Joyal, Jonathan Afilalo, Stéphane Rinfret

    Résumé Résumé Plan Plan  
  • ·Remodeling is a more important determinant of lumen size than atheroma burden in left main coronary artery disease

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    Colin Berry, Stéphane Noble, Reda Ibrahim, Jean Grégoire, Sylvie Levesque, Philippe L. L'Allier, Jean-Claude Tardif

    Résumé Résumé Plan Plan
  • ·Relative spatial distributions of coronary artery bypass graft insertion and acute thrombosis: A model for protection from acute myocardial infarction

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    Cathy Jeon, Susana C. Candia, John C. Wang, Elizabeth M. Holper, Michelle Ammerer, Richard E. Kuntz, Laura Mauri

    Résumé Résumé Plan Plan  
  • ·Clopidogrel pretreatment in ST-elevation myocardial infarction patients transferred for percutaneous coronary Intervention

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    David M. Larson, Sue Duval, Scott S. Sharkey, Christopher Solie, Craig Tschautscher, Daniel L. Lips, M. Nicholas Burke, Steven Steinhubl, Timothy D. Henry

    Résumé Résumé Plan Plan  
  • ·Correction

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    Mihai Gheorghiade

    
  • ·Correction

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  • ·Correction

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    Seung-Woon Rha

    

• Letters to the Editor

  • ·The dilemma of surgical or percutaneous approach in aortic stenosis: A reliable risk score is needed

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    Iñigo Lozano, David Calvo, Juan Rondan, Pablo Avanzas

    
  • ·Cardiovascular disease risk profiles

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    T. Eugene Day, Eric Goldlust

    
  • ·Letter to the Editor Re: Krishnaswamy

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    Miquel Fiol, Andrés Carrillo, Antonio Bayés de Luna

    
  • ·Letter to the Editor—Krishnaswamy response to Fiol

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    Amar Krishnaswamy, Michael Lincoff, Venu Menon