Sommaire

• • ·Editorial Board

    Page :i

    
• • ·Consensus statement on diagnosis, investigation, treatment and prevention of acute bacterial meningitis in immunocompetent adults

    Page :1-15

    N. Begg, K.A.V. Cartwright, J. Cohen, E.B. Kaczmarski, J.A. Innes, C.L.S. Leen, D. Nathwani, M. Singer, L. Southgate, W.T.A. Todd, P.D. Welsby, M.J. Wood

    
• • ·Lipid amphotericin B combinations; ‘la crème de la créme’?

    Page :16-20

    R.J. Hay

    
• • ·Nucleic acid amplification for mycobacterial diagnosis

    Page :21-26

    Gaby E Pfyffer

    
• • ·Gram-positive endocarditis

    Page :27-31

    F.K. Gould

    
• • ·AIDS-Associated cryptococcal meningitis in Rwanda (1983–1992): Epidemiologic and diagnostic features

    Page :32-37

    J. Bogaerts, D. Rouvroy, H. Taelman, A. Kagame, M.A. Aziz, D. Swinne, J. Verhaegen

    Résumé Résumé
• • ·Immune responses to administration of a vaccine against Haemophilus influenzae Type B in splenectomized and non-splenectomized patients

    Page :38-41

    S. Li Volti, A. Sciotto, M. Fisichella, A. Sciacca, S.E. Munda, A. Mangiagli, G. Li Volti, L. Lupo

    Résumé Résumé
• • ·Meningococcal carriage in relation to an outbreak of invasive disease due to Neisseria meningitidis serogroup C in the Netherlands

    Page :42-48

    M.A.E. Conyn-van Spaendonck, R. Reintjes, L. Spanjaard, E. van Kregten, A.G. Kraaijeveld, P.H.A. Jacobs

    Résumé Résumé
• • ·Maternal infectious morbidity following multiple courses of betamethasone

    Page :49-54

    Siegfried Rotmensch, Tali H. Vishne, Claudio Celentano, Michael Dan, Zion Ben-Rafael

    Résumé Résumé
• • ·Cerebrospinal fluid cytokine levels and dexamethasone therapy in bacterial meningitis

    Page :55-60

    Shouichi Ohga, Kenji Okada, Kohji Ueda, Hidetoshi Takada, Mitsuhiro Ohta, Tomonobu Aoki, Naoko Kinukawa, Sumio Miyazaki, Toshiro Hara

    Résumé Résumé
• • ·High rates of disseminated infection due to non-tuberculous mycobacteria among AIDS patients in Finland

    Page :61-67

    Matti A. Ristola, C.Fordham von Reyn, Robert D. Arbeit, Hanna Soini, Jukka Lumio, Annamari Ranki, Suvi Bühler, Richard Waddell, Anna N.A. Tosteson, J.O. Falkinham, Carol H. Sox

    Résumé Résumé
• • ·Parvovirus B19 infection induces apoptosis of erythroid cells in vitro and in vivo

    Page :68-76

    Nobuo Yaegashi, Takenari Niinuma, Hiroshi Chisaka, Shigeki Uehara, Stanley Moffatt, Kohtaro Tada, Mitsunari Iwabuchi, Yasuko Matsunaga, Masahiro Nakayama, Chikao Yutani, Yoshiyuki Osamura, Emi Hirayama, Kunihiro Okamura, Kazuo Sugamura, Akira Yajima

    Résumé Résumé
• • ·Diagnosis of Pneumocystis carinii pneumonia: Immunofluorescence staining, simple PCR or nPCR

    Page :77-80

    Mohammad Akbar Khan, Nadia Farrag, Philip Butcher

    Résumé Résumé
• • ·Anti-neutrophil cytoplasmic autoantibodies (ANCA) to bactericidal/permeability-increasing (BPI) protein recognize the carboxyl terminal domain

    Page :81-87

    Austin C. Dunn, Russell S. Walmsley, Russell L. Dedrick, Andrew J. Wakefield, Christopher M. Lockwood

    Résumé Résumé
• • ·Acute disseminated histoplasmosis complicated with hypercalcaemia

    Page :88-90

    J.W. Liu, T.C. Huang, Y.C. Lu, H.T. Liu, C.C. Li, J.J. Wu, J.W. Lin, W.J. Chen

    Résumé Résumé
• • ·Mycoplasma hominis bacteraemia not associated with genital infections

    Page :91-94

    Manuel L. Fernández Guerrero, JoséManuel Ramos, Francisco Soriano

    Résumé Résumé
• • ·Clostridium difficile infection of a prosthetic joint presenting 12 months after antibiotic-associated diarrhoea

    Page :94-96

    James McCarthy, Neil Stingemore

    Résumé Résumé
• • ·Shiga toxin 2 promotes the stem cell differentiation into granulocytes in the bone marrow causing marked granulocytosis in the peripheral blood

    Page :97

    Yosuke Aoki, Yukiyo Yosida, Tae Takeda

    
• • ·An unusual case of mixed bacterial meningitis in an immunocompetent adult

    Page :98

    R.S. Prasad, G.S. Khuraijam

    
• • ·ΠPOTEYσ

    Page :99-100

    
• • ·Treating chronic viral hepatitis

    Page :A2

    Janice Main

    
• • ·Will antiviral drug resistance assays become routine?

    Page :A2

    Deanan Pillay

    
• • ·When should we treat respiratory virus infections?

    Page :A2

    Frederick G. Hayden

    
• • ·Host genetics and infectious disease: Current progress in the search for mycobacteria-susceptibility genes?

    Page :A3

    Richard Bellamy

    
• • ·Microbial strategies to escape phagocytic killing

    Page :A3

    J.Simon Kroll

    
• • ·Molecular mechanisms of human cell targeting by phase and antigenically variable components of meningococci

    Page :A4

    M. Virji

    
• • ·Environmental sensing and genetic switching in Staphylococcus aureus

    Page :A4

    Simon J. Foster

    
• • ·Borrelia: A model of microbial host adaptation

    Page :A4

    K. Kurtenbach

    
• • ·The changing face of medical microbiology

    Page :A5

    J.David Williams

    
• • ·Intravascular chatheter infections

    Page :A5

    Beryl A. Oppenheim

    
• • ·Travel medicine, art or science?

    Page :A5

    R.H. Behrens

    
• • ·Evidence base practice - community acquired pneumonia

    Page :A5

    Robert C. Read

    
• • ·Syphilis - clinical aspects

    Page :A6

    M.A. Waugh

    
• • ·Antifungal prophylaxis in neutropenia - is it worth it?

    Page :A6

    D.W. Denning, P. Donnelly

    
• • ·Control of meningococcal cases and outbreaks

    Page :A6

    James Stuart

    
• • ·Over-the-counter antimicrobials

    Page :A6

    Kate Gould

    
• • ·Cytomegalovirus (CMV) disease and detection of human herpesvirus 6 (HHV6) DNA in renal transplant recipients

    Page :A7

    C.Y.W. Tong, J.S.M. Peiris, C.Y. Cheung, H. Williams, A. Bakran

    
• • ·The trent hepatitis C virus study group cohort: The first 962 patients - epidemiology

    Page :A7

    A. Mohsen, M.W. McKendrick, S. Ryder, R. Finch, K. Neal, W. Irving, M.L. Schmid, S.T. Green, R.C. Read, Y. Dawes

    
• • ·Macrophage expressed FasL induces CD4 T-cell apoptosis in HIV infection

    Page :A7

    D.H. Dockrell, A.D. Bradley, C.V. Paya

    
• • ·ailure of infants to downregulate respiratory syncytial virus-induced interleukin-8 secretion

    Page :A7

    L.H. Thomas, M. Sharland, J.S. Friedland

    
• • ·Lack of efficacy of 23-valent penumococcal polysaccharide vaccine in HIV-1-infected uganda adults

    Page :A8

    N. French, J. Nakiying, L. Carpenter, E. Lugadda, C. Watera, J. Whitworth, C. Gilks

    
• • ·Rapid large increase in meningococcal carriage rates in first year university students

    Page :A8

    K.R. Neal, J. Nguyen-Van-Tam, N. Jeffrey, R.J. Madeley, K. Job, J. Pearson, M.C. Wale, K. Ait-Tahar, R.C. Slack, D.A.A. Ala'Aldeen

    
• • ·Susceptibility to superantigen-associated infection can be determined by MHC class II

    Page :A8

    S. Sriskandan, M. Unnikrishnan, J. Cohen, D.M. Altmann

    
• • ·Optimising laboratory ascertainment of meningococcal disease by non-culture case confirmation using serodiagnosis PCR and improved latex agglutination methods

    Page :A8

    E.B. Kaczmarski, R. Borrow, S.J. Gray, M. Guiver, J. Marsh, A.J. Fox

    
• • ·Immunological memory 5 years after meningococcal conjugate vaccination

    Page :A9

    J.M. MacLennan, J.J. Deeks, S. Obaro, D. Williams, G.M. Carlone, E.R. Moxon, B.M. Greenwood

    
• • ·Human T cell responses to the antigen ESAT-6 characterize vaccine candidate and potential diagnostic test for tuberculosis

    Page :A9

    A. Lalvani, A. Pathan, R. Brookes, H. Pritchard, R. Wilkinson, G. Pasvol, A. Hill

    
• • ·The role of the RDXA gene in the evolution of metronidazole resistance in Helicobacter pylori

    Page :A9

    P.J. Jenks, R.L. Ferrero, A. Labigne

    
• • ·Phagocytosis of mycobacterium tuberculosis stimulates secretion of MMP-1 and MMP-9

    Page :A9

    N.M. Price, J.S. Friedland

    
• • ·Examination of the epidemiology of campylobacter jejuni/coli in an urban population using a flagellin typing scheme

    Page :A10

    D. Birkenhead, P.M. Hawkey

    
• • ·Prevalence of gastrointestinal symptoms and the irritable bowel syndrome one year after infection with E. cli O157

    Page :A10

    S. Dundas, W.T.A. Todd

    
• • ·A comparison of a simple, rapid, PCR-RFLP flagellin typing scheme for campylobacter jejuni/coli with heat stable serotyping

    Page :A10

    D. Birkenhead, P.M. Hawkey

    
• • ·Is it appropriate to use permanent staining techniques routinely on faeces samples in a diagnostic microbiology laboratory in the UK?

    Page :A10

    S.J. Hudson, A.J. Hedley

    
• • ·Small bowel microflora and neonatal necrotising enterocolitis

    Page :A11

    C.M. Hoy, C.M. Wood, P.M. Hawkey, J.W.L. Puntis

    
• • ·Production of diarrhoeal toxin by bacillus species in hospital-prepared infant feeds

    Page :A11

    N.J. Rowan, J.g. Anderson, C.G. Gemmell, K. Deans

    
• • ·Random mutagenesis of the helicobacter pylori genome

    Page :A11

    P.J. Jenks, A. Labigne

    
• • ·Molecular pathogenesis of Shigella sonnei

    Page :A11

    A. Tuanyok, P. Shears

    
• • ·Resistance to metronidazole in helicbacter pylori and its effect on the efficacy of eradication therapy

    Page :A12

    P.J. Jenks, A. Labigne, R. Ferrero

    
• • ·Pleomorphic culture forms of listeria monocytogenes (serovar 4b) differ in morphology, enzymology, antigenicity and heat tolerance

    Page :A12

    N.J. Rowan, J.G. Anderson, A.A. Candlish, K. Deans

    
• • ·Identification of conserved, CD8+ cytotoxic T cell epitopes in ESAT-6, a tuberculosis vaccine candidate

    Page :A12

    A. Pathan, R. Brookes, H. Pritchard, R. Wilkinson, G. Pasvol, A. Hill, A. Lalvani

    
• • ·An evaluation of escherichia coli type 1 fimbriae regulation in bacteriuria of pregnancy

    Page :A12

    J.Clive Graham, Julian B.S. Leathart, David L. Gally

    
• • ·Intracellular processing of Streptococcus pneumoniae by alveolar macrophages is determined by opsonins

    Page :A13

    G.R.B. Irving, S.B. Gordon, R.A. Lawson, R.C. Read

    
• • ·The reversible loss of the capsulated “smooth” phenotype when streptococcus pneumoniae is grown in biofilm

    Page :A13

    R.K. Budhani, J.K. Struthers, P.A. Tarpey

    
• • ·Invasive meningocccal disease among university undergraduates association with catered halls of residence

    Page :A13

    J.S. Nguyen-Van-Tam, K.R. Neal, P. Monk, S.J. O'Brien, J. Stuart, M. Ramsay

    
• • ·Clinical correlates of adhesion and slime production in coagulase-negative staphylococcal prospthetic joint infection

    Page :A13

    C. Davies, S. Peacock, N. Day, A. Berendt

    
• • ·Carriage of neisseria meningitidis in a village community after mass antibiotic and vaccine programmes

    Page :A14

    K.R. Neal, M.C. Newlands, K. Ashford, M. Baker, M.C.J. Wale, J.S. Nguyen-Van-Tam, D.A.A. Ala'Aldeen

    
• • ·Isolation of viable toxoplasma gondii from ready-to-eat cured meat

    Page :A14

    J. Johnson, M.R. Warnekulasuriya, R.E. Holliman

    
• • ·Death in meningococcal disease and polymorphisms of pro-inflammatory cytokine genes

    Page :A14

    R.C. Read, R. Borrow, E.B. Kaczmarski, A.J. Fox, G.W. Duff, F.S. di Giovini

    
• • ·Population genetics and epidemiology of serogroup B meningococci isolated in the United Kingdom

    Page :A14

    Fariborz J.R. Abadi, D.E. Yakubu, J.Z. Jordens, T.H. Pennington

    
• • ·Schistosomiasis in U.K. travellers

    Page :A15

    J. Salmon, E.L.C. Ong

    
• • ·Mefloquine pharmacokinetics when combined with artesunate in children with acute falciparium malaria

    Page :A15

    R.N. Price, J. Simpson, F. Nosten, N.J. White

    
• • ·The pathophysiological and prognostic significance of acidosis in severe adult malaria

    Page :A15

    N. Day, N. Phu, T. Hien, N. White

    
• • ·Travel health advice for UK medical students on overseas elective study periods

    Page :A15

    P.J. Moss, N.J. Beeching

    
• • ·The periodicity of imported vivax malaria in Birmingham

    Page :A16

    M. Dedicoat, P. Venkatesan, C. Ellis

    
• • ·Chryseobacterium meningosepticum outbreak associated with colonisation of water taps in a neonatal intensive care unit

    Page :A16

    S.N. Hoque, J. Graham, S. Tabaqchali

    
• • ·Risk factors for invasive Haemophilus influenzae (HI) disease in the post-conjugate vaccine era

    Page :A16

    B. Olowokure, I. Blair, J. Hawker, N. Spencer

    
• • ·An audit of the outcome of screening new arrivals to the UK for tuberculosis

    Page :A16

    K. Ratcliffe, U. Scholl, P. Nair

    
• • ·Three cases of pyomyositis in previously healthy adults

    Page :A17

    J. Sandoe, T. Collyns, G. Radcliffe, J. Lawton, K. Kerr, M. Denton

    
• • ·Distribution of teicoplanin- and vancomycin-resistant strains amongst coagulase-negative staphylococci in a teaching hospital

    Page :A17

    M. Khan, R. Holliman

    
• • ·The changing pattern of bacteraemia at a children's hospital, 1977, 1987 & 1997

    Page :A17

    J. Gray, R.H. George

    
• • ·Origins of gram-positive bacteria causing bacteraemia in a bone marrow transplant patient

    Page :A17

    H.F. Kennedy, D. Morrison, M.E. Kaufmann, M.S. Jackson, J. Bagg, B.E.S. Gibson, C.G. Gemmell, J.R. Michie

    
• • ·Surveillance of bacteraemia in England and Wales 1990 to 1997

    Page :A18

    M. Reacher, A. Shah, M. Wale, D. Livermore, R. George

    
• • ·Vancomycin-resistant enterococci (VRE): To screen or not to screen?

    Page :A18

    J. Gray, H.E. Jones, J. Suviste, R.H. George

    
• • ·Molecular epidemiology of an outbreak of Staphylococcus epidermidis in a neonatal intensive care unit

    Page :A18

    C.M. Pope, G. Hogg, A. Coffey, J. Fullerton, S. Christie, J.G. Barr, C.H.W. Webb, H.L. Halliday, K.B. Bamford

    
• • ·An outbreak of vancomycin-resistant enterococci on a renal ward-“that sinking feeling”

    Page :A18

    J. Hall, T. Collyns, J. Sandoe, K. Kerr, M. Denton, C. Porter, P. Parnell, M. Wilcox, V. Keer, G. Woodrow

    
• • ·Betadine cream as an alternative to mupirocin nasal ointment - An in-vitro assessment

    Page :A19

    R.L.R. Hill, N. Desai, M.W. Casewell, J.J. Wade

    
• • ·The prognosis for children with MRSA

    Page :A19

    J. Gray, R.H. George

    
• • ·Methicillin resistant Stapylococcus aureus (MRSA) colonisation: A community based point prevalence survey

    Page :A19

    L. Abudu, I. Blair, A. Fraise, K.K. Cheng

    
• • ·MRSA with reduced susceptibility to glycopeptides following prolonged teicoplanin therapy

    Page :A19

    R.L.R. Hill, M. Edmonds, L. Fitch, G. Cavell, J.J. Wade

    
• • ·Methicillin resistant Staphylococcus aureus in fife 1990–1997

    Page :A20

    P.A. Garnett, A.S. Whyte, I.F. Laurenson, D. Morrison, B. Cosgrove

    
• • ·Bacteraemia and diabetes

    Page :A20

    H.C. Mwandumba, N.J. Beeching, F.J. Nye, G.V. Gill

    
• • ·Rapid detection of MRSA by multiplex PCR

    Page :A20

    A.M. Kearns, P.R. Seiders, J. Wheeler, R. Freeman, M. Steward

    
• • ·Audit of management of methicillin-resistant Staphylococcus aureus (MRSA)

    Page :A20

    C. Howard, A. Trail, P. Rowland, P. Chadwick, M. Keaney

    
• • ·Speed of action of antiseptics in the presence of organic soil

    Page :A21

    S.A.W. Gibson, L. Jonhston, J. Prince, L. Carr

    
• • ·Comparative evaluation of new and old methods for the diagnosis of pneumococcal pneumonia

    Page :A21

    J. Wheeler, R. Freeman, M. Steward, K. Henderson, M.J.S. Lee

    
• • ·Bioassay for the assessment of the in vitro efficacy of novel drug delivery system against Gardnerella vaginalis

    Page :A21

    M. Law, J.F. Porter

    
• • ·Impact of guidelines for the diagnosis of urinary tract infection using rapid reagent strips

    Page :A21

    B.I.F. Batchelor, D.W.M. Crook, J. Anderson, I.C.J.W. Bowler

    
• • ·In vitro efficacy of a novel drug delivery system for the treatment of vaginal candidiasis

    Page :A22

    M. Law, J.F. Porter

    
• • ·Risk factors for antibiotic resistance in isolates of Haemophilus influenzae

    Page :A22

    R.A. Seaton, D.T. Steinke, G. Phillips, T.M. McDonald, P. Davey

    
• • ·Outpatient intravenous antimicrobial treatment of soft tissue infections

    Page :A22

    S. Pettett, R.B.S. Laing, C.C. Smith, J.G. Douglas

    
• • ·Safety and efficacy of gentamicin therapy

    Page :A22

    K.O. Buabeng, A.R. Mackenzie, I. Cook, R.B.S. Laing, I.M. Gould, B. Jappy

    
• • ·Factors associated with trimethoprim resistant bacteria isolated from community urine samples

    Page :A23

    D. Steinke, R.A. Seaton, G. Phillips, T. MacDonald, P.G. Davey

    
• • ·Survival characteristics of pseudomonads exposed to high concentrations of tobramycin

    Page :A23

    A. Qureshi, M. Denton, K. Kerr

    
• • ·Extended-spectrum β-lactamase-producing Enterobacteriaceae in an algerian hospital

    Page :A23

    F. M'Zali, M. Denton, J. Heritage, A. Ait-ameur, P. Hawkey

    
• • ·Linezolid: Susceptibility testing using different methodologies

    Page :A23

    J.M.T. Hamilton-Miller, S. Shah

    
• • ·Induced expression of a novel Aspergillus fumigatus putative drug efflux gene in response to itraconazole

    Page :A24

    J.W. Slaven, M.J. Anderson, G.K. Dixon, I.S. Roberts, D.W. Denning

    
• • ·Determination of ciprofloxacin susceptibility in clinical isolates of Pseudomonas aeruginosa

    Page :A24

    J. Wright, O.M. Murphy, G. Dickinson, A. Galloway

    
• • ·Pseudomonas aeruginosa and resistance to ciprofloxacin in a spinal injuries unit - A longitudinal study

    Page :A24

    J. Wright, O.M. Murphy, G. Dickinson, A. Galloway

    
• • ·Clonal analysis of antibiotic resistant E.coli 0157

    Page :A24

    D.H. Mitwalli, F.J.R. Abadi, F. Thomson-Carter, T.H. Pennington

    
• • ·The design, development and running of a website for medical education: The Aspergillus website as an example

    Page :A25

    E. Prebble, M.J. Anderson, D.W. Denning

    
• • ·Prevention of nosocomial aspergillosis:-A multidisciplinary approach

    Page :A25

    F. Fitzpatrick, S. Prout, A. Gilleece, W.W. Hall, L.E. Fenelon, O.M. Murphy

    
• • ·The safety and pharmacokinetics of ZD0870, a novel azole antifungal agent

    Page :A25

    P.J. Moss, R.P. Smith, R.A. Yates

    
• • ·HIV-1 seropositivy in ante-natal women in Uganda shows a decline

    Page :A25

    F.G. Rushambuza

    
• • ·HIV and AIDS in the United Kingdom priorities for the national strategy

    Page :A26

    A. Nicoll

    
• • ·HIV: A multisystem disease. An investigation to determine which bodily systems feature most

    Page :A26

    Andrea Knapman, Alison Uriel, Cynthia Murphy, Bibhat K. Mandal

    
• • ·Osteonecrosis and antiphospholipid antibodies in patients with HIV disease, a report of four new cases

    Page :A26

    A. Mastroianni, C. Cancellieri, O. Coronado, R. Manfredi, S. Pignatari

    
• • ·Efficacy of pentoxifylline and haart in AIDS-associated progressive multifocal leukoencephalopathy

    Page :A26

    A. Mastroianni, C. Cancellieri, S. Pignatari

    
• • ·Comparison of efficacy of hard and soft gel formulations of saquinavir in HIV patients

    Page :A27

    A.J. Uriel, P. Tilson, G. Corbett, B.K. Mandal

    
• • ·Immunogenetics of HTLV-I infection

    Page :A27

    K.J.M. Jeffery, K. Usuku, M. Nagai, M. Osame, C.R.M. Bangham

    
• • ·Inhibition of HIV-1 replication in T lymphocytes by expression of antisense RNA targetting the 5′ leader region

    Page :A27

    D. Chadwick, A.M.L. Lever

    
• • ·Retrospective audit of day-case percutaneous liver biopsy in patients with hepatitis B & C requiring hospitalization

    Page :A27

    M.L. Schmid, M.W. McKendrick, A.H. Mohsen, S.T. Green

    
• • ·Diagnosis of hepatitis C infection by Elisa detection of urinary antibody

    Page :A28

    R. Cunningham, J.L. Northwood

    
• • ·Transfusion-transmitted virus (TTV) in drug users

    Page :A28

    C.Y.W. Tong, N. Kennedy, H.F. Williams, S. Moss, N.J. Beeching

    
• • ·Major histocompatibility complex (MHC) polymorphisms and severe liver disease due to hepatitis C virus

    Page :A28

    E.J. Minton, D. Smillie, P. Smith, M.W. McKendrick, J.C.E. Underwood

    
• • ·Epidemiology and RNA fingerprinting of rota virus in Ireland

    Page :A28

    M. Lynch, F. O'Halloran, D. Whyte, B. Cryan, S. Fanning

    
• • ·The changing face of opportunistic infections in AIDS

    Page :A29

    A. Boyd, H. Williams