Sommaire

• • ·Introduction

    Page :1

    Philip M Hanno, Vicki Ratner, Grannum R Sant, Alan J Wein

    
• • ·Clinical highlights of the national institute of diabetes and digestive and kidney diseases/interstitial cystitis association scientific conference on interstitial cystitis

    Page :2-6

    Philip M Hanno, Grannum R Sant

    Résumé Résumé Plan Plan
• • ·Basic science research on the urinary bladder and interstitial cystitis: new genetic approaches

    Page :7-8

    Monica Liebert

    Résumé Résumé Plan Plan
• • ·Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor–like growth factor, and epidermal growth factor as urine markers for interstitial cystitis

    Page :9-14

    Susan K Keay, Chen-Ou Zhang, Joanna Shoenfelt, Deborah R Erickson, Kristene Whitmore, John W Warren, Richard Marvel, Toby Chai

    Résumé Résumé Plan Plan  
• • ·Urine markers of interstitial cystitis

    Page :15-21

    Deborah R Erickson

    Résumé Résumé Plan Plan
• • ·Concordance of interstitial cystitis in monozygotic and dizygotic twin pairs

    Page :22-25

    John W Warren, Susan K Keay, Deborah Meyers, Jianfeng Xu

    Résumé Résumé Plan Plan  
• • ·Observations on the presentation, diagnosis, and treatment of interstitial cystitis in men

    Page :26-29

    John B Forrest, Quang Vo

    Résumé Résumé Plan Plan
• • ·Is interstitial cystitis an underdiagnosed problem in children? A diagnostic and therapeutic dilemma

    Page :30-31

    John M Park

    
• • ·Interstitial cystitis: a chronic visceral pain syndrome

    Page :32-39

    Ursula Wesselmann

    Résumé Résumé Plan Plan  
• • ·Estrogen and neuroinflammation

    Page :40-46

    Dale E Bjorling, Zun-Yi Wang

    Résumé Résumé Plan Plan  
• • ·Mast cell involvement in interstitial cystitis: a review of human and experimental evidence

    Page :47-55

    Theoharis C Theoharides, Duraisamy Kempuraj, Grannum R Sant

    Résumé Résumé Plan Plan  
• • ·Dynamic interactions between host and pathogen during acute urinary tract infections

    Page :56-61

    Joel D Schilling, Matthew A Mulvey, Scott J Hultgren

    Résumé Résumé Plan Plan  
• • ·Psychometric validation of the O’leary-Sant interstitial cystitis symptom index in a clinical trial of pentosan polysulfate sodium

    Page :62-66

    Deborah P Lubeck, Kristene Whitmore, Grannum R Sant, Sarah Alvarez-Horine, Chinglin Lai

    Résumé Résumé Plan Plan
• • ·Biopsy features are associated with primary symptoms in interstitial cystitis: results from the interstitial cystitis database study

    Page :67-81

    John E. Tomaszewski, J.Richard Landis, Valentina Russack, Thomas M. Williams, Li-Ping Wang, Christine Hardy, Colleen Brensinger, Yvonne L. Matthews, Susan T. Abele, John W. Kusek, Lee M. Nyberg, The Interstitial Cystitis Database Study Group

    Résumé Résumé Plan Plan  
• • ·Interstitial cystitis: current issues and controversies in diagnosis

    Page :82-88

    Grannum R Sant, Philip M Hanno

    Résumé Résumé Plan Plan
• • ·Current controversies that adversely affect interstitial cystitis patients

    Page :89-94

    Vicki Ratner

    Résumé Résumé Plan Plan
• • ·The epidemiology of interstitial cystitis: is it time to expand our definition?

    Page :95-99

    John W Kusek, Leroy M Nyberg

    Résumé Résumé Plan Plan
• • ·Interstitial cystitis: past and future

    Page :101-102

    W.D Steers

    
• • ·Increased plasma norepinephrine concentrations in cats with interstitial cystitis

    Page :102

    T Buffington, K Pacak

    
• • ·Interstitial cystitis: a chronic visceral pain syndrome

    Page :102

    U Wesselmann

    
• • ·Stimulation of human urothelial cell proliferation by estrogen receptor activation

    Page :102-103

    J Teng, Z.Y Wang, D Bjorling

    
• • ·Gene-regulation during bladder neurogenic inflammation

    Page :103

    R Saban

    
• • ·Hemidesmosomes in bladder epithelial cells

    Page :103

    J.C.R Jones

    
• • ·Stretch-regulated exocytosis of discoidal vesicles in urinary bladder epithelium

    Page :103-104

    G Apodaca

    
• • ·Plasticity of the urothelial phenotype: effects of gastrointestinal mesenchyme/stroma and implications for urinary tract reconstruction

    Page :104

    L.S Baskin

    
• • ·Antiproliferative factor, heparin-binding epidermal growth factor–like growth factor, and epidermal growth factor: sensitive and specific urine markers for interstitial cystitis

    Page :104

    S Keay, C.-O Zhang, R Marvel, T Chai

    
• • ·Positive and negative regulators of human urothelial cell proliferation

    Page :104-105

    J.A Bassuk

    
• • ·Role of prostaglandins in bladder smooth muscle cell gene expression

    Page :105

    J.M Park

    
• • ·Uropathogenic escherichia coli: interactions with bladder epithelium

    Page :105-106

    S.J Hultgren

    
• • ·RTX exotoxins

    Page :106-107

    M.B. Chancellor

     
• • ·Observations on the management of interstitial cystitis in men

    Page :107

    J Forrest, Q Vo

    
• • ·Interstitial cystitis in children: not a rare entity

    Page :107

    G.A Schuster

    
• • ·Interstitial cystitis in India: important lessons

    Page :107-108

    N Mishra

    
• • ·Stretch-induced bladder smooth muscle cell (SMC) proliferation is mediated by RHAMM-dependent extracellular-regulated kinase (erk) signaling

    Page :109

    K Aitken, D.J Bägl

    
• • ·Cysteinyl-leukotriene D₄ receptors in smooth muscle cells

    Page :109

    K Bouchelouche, T Horn, J Nordling, S Larsen, T Hald

    
• • ·Calcium signaling in cultured human detrusor smooth muscle cells from patients with interstitial cystitis

    Page :109-110

    K Bouchelouche, T Horn, J Nordling, S Larsen, T Hald, P Bouchelouche

    
• • ·K_ATP channel currents regulate membrane potential in freshly isolated human and rat bladder smooth muscle cells

    Page :110

    H.-Z Wang, G.J Christ

    
• • ·Changes in electrical properties of detrusor smooth muscle in the STZ (streptozotocin)–diabetic rat

    Page :110-111

    V Karicheti, C Santizo, W Zhao, E Kuo, G Shenk, A Melman, G.J Christ

    
• • ·Bladder instillation of “naked” hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo

    Page :111

    G.J Christ, N.S Day, C Santizo, W Zhao, T Sclafani, V Karicheti, M Valcic, A Melman

    
• • ·Gap junction channel activity in cultured human bladder smooth muscle cell pairs: gating and unitary conductances

    Page :111

    H.-Z Wang, S.W Lee, N.S Day, G.J Christ

    
• • ·Intravesical ultrapotent vanilloid receptor agonists: acute effects on animal models of bladder irritation

    Page :111-112

    M.O Fraser, Y.-C Chuang, D.-Y Kim, C.M Brady, J.M Beckel, N Yoshimura, W.C de Groat, M.B Chancellor

    
• • ·A reliable, nondestructive animal model for interstitial cystitis: intravesical low-dose protamine sulfate combined with physiological concentrations of potassium chloride

    Page :112

    M.O Fraser, Y.-C Chuang, J.P Lavelle, N Yoshimura, W.C de Groat, M.B Chancellor

    
• • ·The effects of ovariectomy on and prostaglandin levels in the rabbit urinary bladder

    Page :112

    P Nichol, L Lee, M.H Parekh, R.M Levin, M.A Hass

    
• • ·Mast cell enzymes alter the connective tissue phenotype of bladder wall fibroblasts and smooth muscle cells

    Page :112-113

    P.S Howard, D Renfrow, S Ford, U Kucich, N Schechter

    
• • ·Protamine sulfate-induced cystitis: a model of selective cytodestruction of the urothelium

    Page :113

    J Lavelle, S Meyers, R Ramage, D Doty, S Bastacky, G Apoddaca, M Zeidel

    
• • ·Long-term effects of urea on urothelial barrier function

    Page :113

    S.A Lewis

    
• • ·Effects of resiniferatoxin on the neurogenic component of feline interstitial cystitis

    Page :114

    P March, B Teng, J Westropp, T Buffington

    
• • ·Effect of mast cell granules on urinary tract epithelial cells in culture

    Page :114

    A Rickard, C Portel, D Lagunoff

    
• • ·cDNA expression arrays: the effects of lactacystin in lipopolysaccharide-induced cystitis

    Page :114-115

    X.C Wang, J.H Kaysen, R Saban, P.L Allen, E.N Benses, T.G Hammond

    
• • ·Continuous bladder infusion methods for studying voiding function in ambulatory mice

    Page :115

    L.S Eichel, A.E Sessions, E.M Messing, E Schwarz, R.W Wood

    
• • ·Assessment of murine bladder permeability with fluorescein: validation with cyclophosphamide and protamine

    Page :115

    L Eichel, K Scheidweiler, J Kost, J Shojaie, E Schwarz, E.M Messing, R Wood

    
• • ·Automated noninvasive measurement of cyclophosphamide-induced changes in murine micturition frequency and volume and demonstration of pharmacologic sensitivity

    Page :115-116

    R Wood, L Eichel, E.M Messing, E Schwarz

    
• • ·Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE)

    Page :116

    N Yoshimura, M.E Franks, K Sasaki, W.F Goins, J Goss, T Yokoyama, M.O Fraser, S Seki, J Fink, J Glorioso, W.C de Groat, M.B Chancellor

    
• • ·Suppression of the tetrodotoxin-resistant sodium channel (PN3/SNS): a possible new treatment for bladder pain

    Page :116-117

    N Yoshimura, S Seki, V Erickson, K Erickson, L Kassotakis, S Novakovic, M.O Fraser, M.B Chancellor, W.C de Groat

    
• • ·Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux

    Page :117

    P Hu, F.-M Deng, F.-X Liang, C.-M Hu, A Auerbach, E Shapiro, X.-R Wu, B Kachar, T.-T Sun

    
• • ·Urothelial function reconsidered: a new role in urinary protein secretion

    Page :117

    F.-M Deng, M Ding, R.M Lavker, T.-T Sun

    
• • ·cDNA array of lipopolysaccharide-induced bladder gene expression

    Page :117

    M.R Saban, N.-B Nguyen, T.G Hammond, R Saban

    
• • ·The psychosocial economic impact of invisible chronic disease: examining the experience of patients with interstitial cystitis

    Page :118

    K Azevedo, C.K Payne

    
• • ·Treatment of interstitial cystitis with montelukast, a leukotriene D₄ receptor antagonist

    Page :118

    K Bouchelouche, J Nordling, T Hald, P Bouchelouche

    
• • ·Recombinant human nerve growth factor in the treatment of interstitial cystitis: preliminary results

    Page :118-119

    J Dimitrakov, J Tchitalov, T Zlatanov, D Dikov, G Rawadi

    
• • ·Practice trends for the management of interstitial cystitis

    Page :119

    D Gershbaum, R Moldwin

    
• • ·Alkalinized intravesical lidocaine to treat interstitial cystitis: absorption kinetics in normal and interstitial cystitis bladders

    Page :119

    R.A Henry, L Patterson, C Nickel, A Morales

    
• • ·The efficacy of calcium glycerophosphate in the prevention of food-related flares in interstitial cystitis

    Page :119-120

    R.A Bologna, A Gomelsky, J.C Lukban, L.M Tu, A.S Holzberg, K.E Whitmore

    
• • ·Evaluation of transvaginal theile massage as a therapeutic intervention for women with interstitial cystitis

    Page :120

    A Holzberg, S Kellog-Spadt, J Lukban, K Whitmore

    
• • ·Medical therapy in interstitial cystitis: the essex experience

    Page :120

    H Lewi

    
• • ·Interstitial cystitis in males

    Page :120-121

    R Indudhara, W Kubricht, K Lloyd

    
• • ·Sacral nerve stimulation as a treatment for urge incontinence and associated pelvic floor disorders at a pelvic floor center: a follow-up study

    Page :121

    R Caraballo, R.A Bologna, J Lukban, K.E Whitmore

    
• • ·The effect of manual physical therapy in patients diagnosed with interstitial cystitis, high-tone pelvic floor dysfunction, and sacroiliac dysfunction

    Page :121-122

    J Lukban, K Whitmore, S Kellogg-Spadt, R Bologna, A Lesher, E Fletcher

    
• • ·Daily stress and symptom exacerbation in interstitial cystitis patients

    Page :122

    N.E Rothrock, S.K Lutgendorf, K.J Kreder, T.L Ratliff, B Zimmerman

    
• • ·A laboratory stress model for examining stress and symptomatology in interstitial cystitis patients

    Page :122

    S.K Lutgendorf, K.J Kreder, N.E Rothrock, T.L Ratliff, B Zimmerman

    
• • ·Interstitial cystitis: a proposal on cardinal symptoms and signs

    Page :122

    S Mortensen, J Nordling, T Horn, T Hald, the Copenhagen Interstitial Cystitis Study Group a

    
• • ·Safety and efficacy of up to 900 mg/day polysulfate sodium (elmiron) in patients with interstitial cystitis

    Page :122-123

    J.C. Nickel, J. Forrest, J. Barkin, C. Payne, P. Mosbaugh

    
• • ·Cystistat for the treatment of interstitial cystitis: a 3-year follow-up study

    Page :123

    J Nordling, S Jørgensen, E Kallestrup

    
• • ·Sacral nerve stimulation in patients with chronic, intractable pelvic pain

    Page :124

    E.J. Paszkiewicz, S.W. Siegel, C. Kirkpatrick, B. Hinkel, J. Keeisha, A. Kirkemo

    
• • ·Effect of physiologic levels of urinary potassium on interstitial cystitis symptoms

    Page :124

    C.K Payne, E Sirinian, K Azevedo

    
• • ·Correlation of symptoms between 2 instruments among interstitial cystitis patients

    Page :124-125

    E Sirinian, C.K Payne

    
• • ·Effects of CP55,940 and methanadamide on detrusor activity

    Page :125

    R.J Theobald

    
• • ·Bladder hypersensitivity of interstitial cystitis complicated by allergic diseases

    Page :125

    T Yamada, T Murayama, H Mita, K Akiyama

    
• • ·Are glomerulations present in patients of other diseases?

    Page :125-126

    N Mishra

    
• • ·To study the effect of hydrodistention on bladder mucosa and submucosa

    Page :126

    N Mishra

    
• • ·Concordance of interstitial cystitis (IC) in identical twins: preliminary data

    Page :126

    J. Warren, T. Jackson, D. Meyers, J. Xu

    
• • ·Fishbein/interstitial cystitis association (ICA) survey of interstitial cystitis among family members of ICA members: preliminary analysis

    Page :126-127

    J. Warren, T. Jackson, D. Meyers, J. Xu

    
• • ·Symptom reports among interstitial cystitis patients

    Page :127

    C Stoney, D Bonfiglio, T Buffington, B Woodworth

    
• • ·Increased urinary excretion of leukotriene E₄ in patients with interstitial cystitis

    Page :128

    K Bouchelouche, B Kristensen, J Nordling, T Horn, S Larsen, T Hald, P Bouchelouche

    
• • ·Corticotropin-releasing hormone perturbations in interstitial cystitis patients: evidence for abnormal sympathetic activity

    Page :128

    J Dimitrakov, J Tchitalov, T Zlatanov, D Dikov, G Rawadi

    
• • ·Chlorpactin instillation releases calcitonin gene-related peptide in interstitial cystitis patients

    Page :128-129

    K Kreder, S Lutgendorf, M.A Knopf, J.P McGillis

     
• • ·Urinary substance P concentration correlates with urinary frequency and urgency in interstitial cystitis patients treated with intravesical dimethyl sulfoxide and not intravesical anesthetic cocktail

    Page :129

    L Kushner, P.Y Chiu, N Brettschneider, A Lipstein, E Eisenberg, O Rofeim, R Moldwin

    
• • ·Clinical characteristics support that interstitial cystitis is a heterogeneous syndrome

    Page :129-130

    M Fall, F Aldenborg, S Johansson, R Peeker

    
• • ·Immunologic and neurobiologic characteristics support that interstitial cystitis is a heterogeneous syndrome

    Page :130

    R Peeker, F Aldenborg, A Dahlström, L Enerbäck, K Haglid, S.L Johansson, J Ya-Li, L Rosengren, M Fall

    
• • ·The effects of hydrodistention on bladder surface mucin

    Page :130

    O Rofeim, D Shupp-Byrne, G.S Mulholland, R.M Moldwin

    
• • ·Overexpression of platelet-derived endothelial cell growth factor (PD-ECGF) factor/thymidine phosphorylase (TP) in interstitial cystitis

    Page :130-131

    T Ueda, M Tamaki, O Ogawa, N Yoshimura

    
• • ·The comparison of clinical and histopathologic features of interstitial cystitis

    Page :131

    T Hanus, L Zámecnı́k, M Jansky, L Jarolı́m, C Povysil, R Benett

    
• • ·Stretch-activated release of adenosine triphosphate by bladder uroepithelia is augmented in interstitial cystitis

    Page :131

    Y. Sun, S. Keay, P. DeDeyne, T. Chai

    
• • ·Human bladder permeability assessment using intravesical fluorescein clearance rate

    Page :131-132

    R Wood, R Pittelli, D Foster, R Mayer, E.M Messing

    
• • ·Bladder microvasculature and the effects of hydrodistention in interstitial cystitis

    Page :132

    A Rosamilia, L Cann, J Scurry, P Rogers, P Dwyer