Sommaire

• Editorial

  • ·The State of Alzheimer’s Research and the Path Forward

    Page :617-619

    Howard M. Fillit, B. Vellas, Y. Hara

    

• Review

  • ·Geroscience and Alzheimer’s Disease Drug Development

    Page :620-632

    Jeffrey Cummings, A.M. Leisgang Osse, J. Kinney

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  • ·Translating the Biology of Aging into New Therapeutics for Alzheimer’s Disease: Senolytics

    Page :633-646

    M. Riessland, Miranda E. Orr

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  • ·Fibrin-Targeting Immunotherapy for Dementia

    Page :647-660

    A.B. Kantor, K. Akassoglou, Jeffrey B. Stavenhagen

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  • ·Opportunities for Cellular Rejuvenation in Alzheimer’s Disease: How Epigenetic Reprogramming and Chaperone-Mediated Autophagy Are Enabling Next Generation Therapeutic Approaches

    Page :661-668

    Sharon Rosenzweig-Lipson

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• Original Research

  • ·ASURE Clinical Trial Protocol: A Randomized, Placebo-Controlled, Proof-of-Concept Study Aiming to Evaluate Safety and Target Engagement following Administration of TW001 in Early Alzheimer’s Disease Patients

    Page :669-674

    Marlies Oosthoek, A. Lili, A. Almeida, O. van Loosbroek, R. van der Geest, I. de Greef-van der Sandt, P. van Bokhoven, S.A.M. Sikkes, C.E. Teunissen, E.G.B. Vijverberg

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• Review

  • ·Modulation of Mitochondrial Function as a Therapeutic Strategy for Neurodegenerative Diseases

    Page :675-685

    Eugenia Trushina, T.K.O. Nguyen, S. Trushin

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  • ·Neuroinflammation, Its Role in Alzheimer’s Disease and Therapeutic Strategies

    Page :686-698

    M. Kiraly, J.F. Foss, Tony Giordano

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  • ·Targeting Endogenous Mechanisms of Brain Resilience for the Treatment and Prevention of Alzheimer’s Disease

    Page :699-705

    H.R.C. Shanks, K.M. Onuska, S.M. Massa, Taylor W. Schmitz, Frank M. Longo

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  • ·Metformin in the Prevention of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias

    Page :706-717

    M. Tahmi, José A. Luchsinger

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  • ·Multimodal Precision Prevention - A New Direction in Alzheimer’s Disease

    Page :718-728

    M. Barbera, D. Perera, A. Matton, F. Mangialasche, A. Rosenberg, L. Middleton, T. Ngandu, A. Solomon, Miia Kivipelto

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  • ·The Critical Role of Biomarkers for Drug Development Targeting the Biology of Aging

    Page :729-742

    M. Owen, N. Bose, L. Nisenbaum, K.A. Partrick, Howard M. Fillit

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• Commentary

  • ·Future of Alzheimer’s Disease Treatment: Combination Therapy and Precision Medicine

    Page :743-745

    Howard M. Fillit, L.K. Nisenbaum, A.H. Burstein

    

• Editorial

  • ·Dietary Cholesterol and Dementia Risk

    Page :746-747

    Lefkos T. Middleton, E. Riboli

    

• Original Research

  • ·High Intake of Dietary Cholesterol Decreases the Risk of All-Cause Dementia and AD Dementia: A Results from Framingham Offspring Cohort

    Page :748-755

    Mingmin Wang, Yanqiu Wang, Y. Zhang, W. Zhang, Y. Wang, R. Fan, Yi Wen

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  • ·Preferences about Future Alzheimer’s Disease Treatments Elicited through an Online Survey Using the Threshold Technique

    Page :756-764

    Sonia Roldan Munoz, S.T. de Vries, G. Lankester, F. Pignatti, B.C. van Munster, I. Radford, L. Guizzaro, P.G.M. Mol, H. Hillege, D. Postmus

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• Brief Communication

  • ·Initial Experiences with Amyloid-Related Imaging Abnormalities in Patients Receiving Aducanumab Following Accelerated Approval

    Page :765-770

    Matthew D. Howe, K.J. Britton, H.E. Joyce, G.J. Pappas, M.A. Faust, B.C. Dawson, M.C. Riddle, S.P. Salloway

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• Original Research

  • ·Lecanemab Clarity AD: Quality-of-Life Results from a Randomized, Double-Blind Phase 3 Trial in Early Alzheimer’s Disease

    Page :771-777

    Sharon Cohen, C.H. van Dyck, M. Gee, T. Doherty, M. Kanekiyo, S. Dhadda, D. Li, S. Hersch, M. Irizarry, L.D. Kramer

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  • ·Safety, Tolerability, Pharmacokinetics and Quantitative Electroencephalography Assessment of ACD856, a Novel Positive Allosteric Modulator of Trk-Receptors Following Multiple Doses in Healthy Subjects

    Page :778-789

    K. Önnestam, B. Nilsson, M. Rother, E. Rein-Hedin, J. Bylund, P. Anderer, M. Kemethofer, M.M. Halldin, J. Sandin, Märta Segerdahl

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  • ·A Randomized Prospective Survey Targeting Knowledge, Barriers, Facilitators and Readiness to Participation in Dementia Research

    Page :790-799

    Martha Sajatovic, L.K. Herrmann, C. Knebusch, K. Sarna, A.J. Lerner, E. Fuentes-Casiano, C.J. Burant

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  • ·Protocol of a Phase II Randomized, Multi-Center, Double-Blind, Placebo-Controlled Trial of S-Adenosyl Methionine in Participants with Mild Cognitive Impairment or Dementia Due to Alzheimer’s Disease

    Page :800-809

    Sarah Holper, R. Watson, L. Churilov, P. Yates, Y.Y. Lim, K.J. Barnham, N. Yassi

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  • ·Baseline Findings of PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE4 Carriers before the Onset of Dementia

    Page :810-820

    Hussein Yassine, I.C. Arellanes, A. Mazmanian, L. De La Cruz, J. Martinez, L. Contreras, N. Kono, B.S. Liu, D. Badie, M.A. Bantugan, A. Grindon, T. Urich, L. D’Orazio, B.A. Emmanuel, H.C. Chui, W.J. Mack, M.G. Harrington, M.N. Braskie, L.S. Schneider

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  • ·Reducing the Effects of Ageing on Cognition with Therapeutic Intervention of an Oral Multi-Nutrient: The REACTION Pilot Trial Study Design

    Page :821-827

    Christian J. Camargo, S. Merritt, M. Modjeski, D.S. Counotte, K. Fernández McInerney

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  • ·Two-Year Prognostic Utility of Plasma p217+tau across the Alzheimer’s Continuum

    Page :828-836

    A. Feizpour, V. Doré, J.D. Doecke, Z.S. Saad, G. Triana-Baltzer, R. Slemmon, P. Maruff, N. Krishnadas, P. Bourgeat, K. Huang, C. Fowler, S.R. Rainey-Smith, A.I. Bush, L. Ward, J. Robertson, R.N. Martins, C.L. Masters, V.L. Villemagne, J. Fripp, H.C. Kolb, Christopher C. Rowe

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  • ·Plasma Oligomer β-Amyloid and White Matter Microstructural Integrity in Cognitively Normal Older Adults According to Cerebral Amyloid Deposition

    Page :837-846

    S.-M. Wang, D.W. Kang, Y.H. Um, S.-H. Kim, C.U. Lee, P. Scheltens, Hyun Kook Lim

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  • ·The Community Engaged Digital Alzheimer’s Research (CEDAR) Study: A Digital Intervention to Increase Research Participation of Black American Participants in the Brain Health Registry

    Page :847-856

    M.R. Mindt, M.T. Ashford, D. Zhu, H. Cham, A. Aaronson, C. Conti, X. Deng, R. Alaniz, J. Sorce, C. Cypress, P. Griffin, D. Flenniken, M. Camacho, J. Fockler, D. Truran, R.S. Mackin, C. Hill, M.W. Weiner, D. Byrd, R.W. Turner, Rachel L. Nosheny

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  • ·Development of a Mobile-First Registry to Recruit Healthy Volunteers and Members of Underrepresented Communities for Alzheimer’s Disease Prevention Studies

    Page :857-864

    R. Aggarwal, E. Sidnam-Mauch, D. Neffa-Creech, A. Plant, E. Williams, E. Shami, U. Menon, S. George, Jessica Langbaum

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  • ·Understanding Barriers and Facilitators to Signing Up for a Mobile-Responsive Registry to Recruit Healthy Volunteers and Members of Underrepresented Communities for Alzheimer’s Disease Prevention Studies

    Page :865-874

    D. Neffa-Creech, R. Aggarwal, C. Stowell, U. Menon, S. George, A. Plant, Jessica Langbaum

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  • ·Protocol for the Brain Health Support Program Study of the Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP): A Prospective 12-Month Intervention Study

    Page :875-885

    Howard H. Feldman, S. Belleville, H.B. Nygaard, M. Montero-Odasso, J. Durant, J.-L. Lupo, C. Revta, S. Chan, M. Cuesta, P.J. Slack, S. Winer, P.W.H. Brewster, S.M. Hofer, A. Lim, A. Centen, D.M. Jacobs, N.D. Anderson, J.D. Walker, M.R. Speechley, G.Y. Zou, H. Chertkow, Canadian Consortium on Neurodegeneration in Aging (CCNA), CAN-THUMBS UP Study Group

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  • ·Genotypic Effects of the TOMM40’523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study

    Page :886-894

    H. Zou, Sheng Luo, H. Liu, M.W. Lutz, D.A. Bennett, B.L. Plassman, K.A. Welsh-Bohmer

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  • ·Social Determinants of Health among Older Adults with Dementia in Urban and Rural Areas

    Page :895-902

    Mairead M. Bartley, H. Baer-Benson, D.R. Schroeder, J.L. St. Sauver, N. Khera, J.M. Griffin

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  • ·Association of Loneliness with Cognitive Functions

    Page :903-908

    Kay Thwe Kyaw, A. Levine

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