Sommario

• • ·Table of Contents

    Pagina :i

    
• • ·Editorial Board

    Pagina :iii

    
• • ·Information for Readers

    Pagina :v

    

• Trial Designs

  • ·Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): Study protocol for a randomized, blinded, crossover trial

    Pagina :10-19

    Xiexiong Zhao, Ye Chen, Guoping Yang, Xingli Li, Xiaohong Tang, Qiong Yang, Liping Peng, Jingle Li, Zhongshu Liang, Anying Li, Wenjuan Wang, Miao Huang, Tao Liu, Xiaogang Li, Weihong Jiang

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  • ·Preventive PCI or medical therapy alone for vulnerable atherosclerotic coronary plaque: Rationale and design of the randomized, controlled PREVENT trial

    Pagina :83-96

    Jung-Min Ahn, Do-Yoon Kang, Pil Hyung Lee, Young-Keun Ahn, Won-Jang Kim, Chang-Wook Nam, Jin-Ok Jeong, In-Ho Chae, Hiroki Shiomi, Paul Hsien Li Kao, Joo-Yong Hahn, Sung-Ho Her, Bong-Ki Lee, Tae Hoon Ahn, Kiyuk Chang, Jei Keon Chae, David Smyth, Gregg W. Stone, Duk-Woo Park, Seung-Jung Park, PREVENT Investigators

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  • ·Near-infrared spectroscopy-intravascular ultrasound to improve assessment of coronary artery disease severity in patients referred for transcatheter aortic valve implantation (The IMPACTavi registry): Design and rationale

    Pagina :114-122

    Masaru Seguchi, Alp Aytekin, Lena Steiger, Philipp Nicol, Costanza Pellegrini, Tobias Rheude, Leif-Christopher Engel, Hector A. Alvarez‐Covarrubias, Erion Xhepa, N. Patrick Mayr, Martin Hadamitzky, Adnan Kastrati, Heribert Schunkert, Michael Joner, Tobias Lenz

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  • ·Rationale and design of a randomized study comparing the Watchman FLX device to DOACs in patients with atrial fibrillation

    Pagina :123-132

    Saibal Kar, Shephal K. Doshi, Mohamad Alkhouli, A. John Camm, Megan Coylewright, Michael C. Gibson, Christopher B. Granger, Mahmut E. Gurol, Kenneth Huber, Moussa Mansour, Devi G. Nair, Andrea Natale, Stuart J. Pocock, Vivek R. Reddy, Walid Saliba, Thomas Christen, Dominic J. Allocco, Kenneth A. Ellenbogen, Martin B. Leon

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  • ·The left atrial appendage closure by surgery-2 (LAACS-2) trial protocol rationale and design of a randomized multicenter trial investigating if left atrial appendage closure prevents stroke in patients undergoing open-heart surgery irrespective of preoperative atrial fibrillation status and stroke risk

    Pagina :133-142

    Christoffer Læssøe Madsen, Jesper Park-Hansen, Akhmadjon Irmukhamedov, Christian Lildal Carranza, Sulman Rafiq, Rafael Rodriguez-Lecoq, Neiser Palmer-Camino, Ivy Susanne Modrau, Emma C. Hansson, Anders Jeppsson, Rakin Hadad, Angel Moya-Mitjans, Anders Møller Greve, Robin Christensen, Helle Gervig Carstensen, Nis Baun Høst, Ulrik Dixen, Christian Torp-Pedersen, Lars Køber, Ismail Gögenur, Thomas Clement Truelsen, Christina Kruuse, Ahmad Sajadieh, Helena Domínguez, LAACS-2 trial Investigators

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  • ·Incorporating a polygenic risk score-triaged coronary calcium score into cardiovascular disease examinations to identify subclinical coronary artery disease (ESCALATE): Protocol for a prospective, nonrandomized implementation trial

    Pagina :163-173

    Michael P. Gray, Yemima Berman, Giordano Bottà, Stuart M. Grieve, Amy Ho, Jessica Hu, Karice Hyun, Jodie Ingles, Garry Jennings, Gary Kilov, Jean-Frederic Levesque, Peter Meikle, Julie Redfern, Tim Usherwood, Stephen T. Vernon, Stephen J. Nicholls, Gemma A. Figtree, PPP-CAD Collaborators, John E. Barlow, Denis Bauer, DanaYemima BradfordBerman, Giordano Bottá, Gemma A. Figtree, Andrew Gilbert, Michael P. Gray, Stuart M. Grieve, Amy Ho, Jessica Hu, Karice Hyun, Garry Jennings, Gary Kilov, Jean-Frederic Levesque, Peter Meikle, Stephen J. Nicholls, Julie Redfern, Bill Stavreski, Graeme Suthers, Tim Usherwood, Andrew Wilson, Stephen Thackway, Caroline Rogers

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• Review Articles

  • ·Gut barrier dysfunction and endotoxemia in heart failure: A dangerous connubium?

    Pagina :40-48

    Francesco Violi, Valentina Castellani, Danilo Menichelli, Pasquale Pignatelli, Daniele Pastori

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• Special Articles

  • ·Patient characteristics and long-term outcomes in patients undergoing transcatheter aortic valve implantation in a failed surgical prosthesis vs in a native valve: A Danish nationwide study

    Pagina :183-189

    Xenia Begun, Jawad H. Butt, Søren L. Kristensen, Peter E. Weeke, Ole De Backer, Jarl E. Strange, Morten Schou, Lars Køber, Emil L. Fosbøl

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• Clinical Investigations

  • ·Temporal Changes in Clinical Characteristics and Outcomes of Adults With Congenital Heart Disease

    Pagina :1-9

    Alexander C. Egbe, William R. Miranda, C. Charles Jain, Elizabeth H. Stephens, Kartik Andi, Omar Abozied, Heidi M. Connolly

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  • ·Impact of standard modifiable cardiovascular risk factors on 2-year all-cause mortality: Insights from an international cohort of 23,489 patients with acute coronary syndrome

    Pagina :20-30

    Maribel González-Del-Hoyo, Xavier Rossello, Vicente Peral, Stuart Pocock, Frans Van de Werf, Chee Tang Chin, Nicolas Danchin, Stephen W-L Lee, Jesús Medina, Yong Huo, Héctor Bueno

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  • ·Comparison of the effectiveness and safety of 2 aspirin doses in secondary prevention of cardiovascular outcomes in patients with chronic kidney disease: A subgroup analysis of ADAPTABLE

    Pagina :31-39

    Kamal Gupta, Harsh Mehta, Hwasoon Kim, Amanda Stebbins, Lisa M. Wruck, Daniel Muñoz, Mark B. Effron, R. David Anderson, Carl J. Pepine, Sandeep K. Jain, Saket Girotra, Darren A. DeWalt, Jeff Whittle, Catherine P. Benziger, Peter Farrehi, Li Zhou, Kirk U. Knowlton, Tamar S. Polonsky, Steven M. Bradley, Robert A. Harrington, Russell L. Rothman, W. Schuyler Jones, Adrian F. Hernandez

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  • ·Associations of N-terminal pro-B-type natriuretic peptide, estimated glomerular filtration rate, and mortality in US adults

    Pagina :49-58

    Bige Ozkan, Morgan E. Grams, Josef Coresh, John W. McEvoy, Justin B. Echouffo-Tcheugui, Scott Z. Mu, Olive Tang, Natalie R. Daya, Hyunju Kim, Robert H. Christenson, Chiadi E. Ndumele, Elizabeth Selvin

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  • ·Transcatheter edge-to-edge repair for chronic functional mitral regurgitation in patients with very severe left ventricular dysfunction

    Pagina :59-71

    Alon Shechter, Ofir Koren, Sabah Skaf, Moody Makar, Tarun Chakravarty, Keita Koseki, Danon Kaewkes, Aum Solanki, Vivek Patel, Raj R. Makkar, Robert J. Siegel

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  • ·Relationship between stent length and very long-term target lesion failure following percutaneous coronary intervention for ST-elevation myocardial infarction in the drug-eluting stents era: insights from the EXAMINATION-EXTEND study

    Pagina :72-82

    Kamil Bujak, Pablo Vidal-Cales, Rami Gabani, Riccardo Rinaldi, Josep Gomez-Lara, Luis Ortega-Paz, Victor Jimenez-Diaz, Marcelo Jimenez-Kockar, Pilar Jimenez-Quevedo, Roberto Diletti, Gianluca Campo, Antonio Silvestro, Jaume Maristany, Xacobe Flores, Loreto Oyarzabal, Antonio De Miguel-Castro, Andrés Iñiguez, Luis Nombela-Franco, Alfonso Ielasi, Maurizio Tespili, Mattie Lenzen, Simone Biscaglia, Soheil Al-Shaibani, Rafael Romaguera, Joan Antoni Gomez-Hospital, Mariusz Gasior, Patrick W. Serruys, Manel Sabate, Salvatore Brugaletta

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  • ·The First Brazilian Cardiovascular Registry of Atrial Fibrillation: Primary Results of the RECALL Study

    Pagina :97-105

    Renato D. Lopes, Pedro G.M. de Barros e Silva, Conrado Roberto Hoffmann Filho, Margaret Assad Cavalvante, Claudia Madeira Miranda, Rodrigo Barbosa Esper, Gustavo Glotz de Lima, Luiz Eduardo Fonteles Ritt, Rose Mary Ferreira Lisboa da Silva, Marcelo A. Nakazone, Adail Paixão Almeida, Ricardo Pavanello, Carlos Eduardo Batista de Lima, Luciano Marcelo Backes, Lucas Hollanda Oliveira, Olga Ferreira de Souza, Adalberto Menezes Lorga Filho, Epotamenides Maria Good God, José Carlos Moura Jorge, Alcirley de Almeida Luiz, Simone Fialho Pereira Pimentel Martins, Rogério Carregoza Dantas, Ricardo D´Oliveira Vieira, Leandro Ioschpe Zimerman, Álvaro Rabelo Alves Júnior, Márcio Jansen de Oliveira Figueiredo, Samara Pinheiro do Carmo Gomes, Lucas Martins de Lima, Lucas Petri Damiani, Ricardo Alkmim Teixeira, Alexandro Alves Fagundes, Eduardo Benchimol Saad, RECALL Investigators

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  • ·Hemodialysis and its impact on patient characteristics, microbiology, cardiac surgery, and mortality in infective endocarditis

    Pagina :106-113

    Anna Stahl, Eva Havers-Borgersen, Lauge Østergaard, Jeppe K. Petersen, Niels E. Bruun, Peter E. Weeke, Søren L. Kristensen, Marianne Voldstedlund, Lars Køber, Emil L. Fosbøl

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  • ·Association between racial residential segregation and Black-White disparities in cardiovascular disease mortality

    Pagina :143-152

    Kriyana P. Reddy, Lauren A. Eberly, Howard M. Julien, Jay Giri, Alexander C. Fanaroff, Peter W. Groeneveld, Sameed Ahmed M. Khatana, Ashwin S. Nathan

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  • ·Cardiac imaging and biomarkers for assessing myocardial fibrosis in children with hypertrophic cardiomyopathy

    Pagina :153-162

    Sonya Kirmani, Pamela K. Woodard, Ling Shi, Taye H. Hamza, Charles E. Canter, Steven D. Colan, Elfriede Pahl, Jeffrey A. Towbin, Steven A. Webber, Joseph W. Rossano, Melanie D. Everitt, Kimberly M. Molina, Paul F. Kantor, John L. Jefferies, Brian Feingold, Linda J. Addonizio, Stephanie M. Ware, Wendy K. Chung, Jean A. Ballweg, Teresa M. Lee, Neha Bansal, Hiedy Razoky, Jason Czachor, Fatima I. Lunze, Edward Marcus, Paul Commean, James D. Wilkinson, Steven E. Lipshultz

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• Research Letters

  • ·Geographic distribution of United States clinical trial sites utilized for guideline changing studies of cholesterol management

    Pagina :174-176

    Marwah E. Alnewais, Lauren Adams, Abdulaziz S. Alfehaid, Shayma Alzaidi, Erin R. Weeda

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  • ·The effect of vitamin D₃ supplementation on atrial fibrillation in generally healthy men and women: The Finnish Vitamin D Trial

    Pagina :177-182

    Jyrki K. Virtanen, Sari Hantunen, Christel Lamberg-Allardt, JoAnn E. Manson, Tarja Nurmi, Matti Uusitupa, Ari Voutilainen, Tomi-Pekka Tuomainen

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