Sommario

• • ·Table of Contents

    Pagina :i

    
• • ·Editorial Board

    Pagina :iii

    
• • ·Information for Readers

    Pagina :v

    

• Curriculum in Cardiology

  • ·Rationale and pathways forward in the implementation of coronary artery calcium-based enrichment of randomized trials

    Pagina :54-65

    Miguel Cainzos-Achirica, Dixitha Anugula, Reed Mszar, Gowtham Grandhi, Kershaw V. Patel, Marcio S. Bittencourt, Ron Blankstein, Michael J. Blaha, Roger S. Blumenthal, Kausik K. Ray, Deepak L. Bhatt, Khurram Nasir

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• Trial Designs

  • ·Left atrial appendage occlusion vs novel oral anticoagulation for stroke prevention in atrial fibrillation: rationale and design of the multicenter randomized occlusion-AF trial

    Pagina :28-38

    Kasper Korsholm, Dorte Damgaard, Jan Brink Valentin, Erik Jerome Stene Packer, Jacob Odenstedt, Juha Sinisalo, Jukka Putaala, Halvor Næss, Mohammad Ahmad Al-Jazi, Jan-Erik Karlsson, Jacob Pontoppidan, Boris Modrau, Jakob Hjort, Kristina Laut Matzen, Søren Paaske Johnsen, Jens Erik Nielsen-Kudsk

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  • ·The NHLBI Study on Long-ter Otcomes after the Multisystem nflammatory yndrome n hildren (MUSIC): Design and Objectives

    Pagina :43-53

    Dongngan T. Truong, Felicia L. Trachtenberg, Gail D. Pearson, Audrey Dionne, Matthew D. Elias, Kevin Friedman, Kerri H. Hayes, Lynn Mahony, Brian W. McCrindle, Matthew E. Oster, Victoria Pemberton, Andrew J. Powell, Mark W. Russell, Lara S. Shekerdemian, Mary Beth Son, Michael Taylor, Jane W. Newburger, for the MUSIC Study Investigators (Supplement 1), Audrey Dionne, Matthew D. Elias, Therese M. Giglia, Kimberly E. McHugh, Andrew M. Atz, Scott A. Pletzer, Dongngan T. Truong, Mark W. Russell, Sean M. Lang, R. Mark Payne, Jyoti K. Patel, Matthew?E. Oster, Lara S. Shekerdemian, Ricardo H. Pignatelli, Kristen Sexson, Brian W. McCrindle, Christopher Lam, Andreea Dragulescu, Rae SM Young, Beth Gamulka, Anita Krishnan, Brett R. Anderson, Kanwal M. Farooqi, Divya Shakti, Aimee S. Parnell, Onyekachukwu J Osakwe, Michelle C. Sykes, Lerraughn Morgan, Carl Y. Owada, Daniel Forsha, Michael R. Carr, Kae Watanabe, Michael A. Portman, Kristen B. Dummer, Jane C. Burns, Adriana H. Tremoulet, Kavita Sharma, Pei-Ni Jone, Michelle Hite Heather Heizer, Keren Hasbani, Shubhika Srivastava, Elizabeth C Mitchell, Camden L. Hebson, Jacqueline R. Szmuszkovicz, Pierre C. Wong, Andrew L. Cheng, Jodie K. Votava-Smith, Shuo Wang, Sindhu Mohandas, Gautam K. Singh, Sanjeev Aggarwal, Yamuna Sanil, Tamara T. Bradford, Juan Carlos G. Muniz, Jennifer S. Li, Michael Jay Campbell, Stephanie S. Handler, J Ryan Shea, Timothy M. Hoffman, Wayne J. Franklin, Arash A. Sabati, Todd T. Nowlen, Maryanne Chrisant

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  • ·Rationale and design of the SMall Annuli Randomized To Evolut or SAPIEN Trial (SMART Trial)

    Pagina :92-102

    Howard C. Herrmann, Mohamed Abdel-Wahab, Guilherme F. Attizzani, Wayne Batchelor, Sabine Bleiziffer, Sarah Verdoliva, Yanping Chang, Hemal Gada, Linda Gillam, Mayra Guerrero, Paul D. Mahoney, Anna Sonia Petronio, Toby Rogers, Joshua Rovin, Molly Szerlip, Brian Whisenant, Roxana Mehran, Didier Tchetche

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  • ·The importance of the design of observational studies in comparative effectiveness research: Lessons from the GARFIELD-AF and ORBIT-AF registries

    Pagina :110-121

    Alfredo E. Farjat, Saverio Virdone, Laine E. Thomas, Ajay K. Kakkar, Karen S. Pieper, Jonathan P. Piccini

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  • ·Rationale and Design of the Groningen Intervention Study for the Preservation of Cardiac Function with Sodium Thiosulfate after St-segment Elevation Myocardial Infarction (GIPS-IV) trial

    Pagina :167-176

    Marie-Sophie LY de Koning, Paulien van Dorp, Solmaz Assa, Minke HT Hartman, Michiel Voskuil, Rutger L Anthonio, Duco Veen, Gabija Pundziute-Do Prado, Tim Leiner, Harry van Goor, Peter van der Meer, Dirk J van Veldhuisen, Robin Nijveldt, Erik Lipsic, Pim van der Harst

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  • ·Catheter ablation for persistent atrial fibrillation: A multicenter randomized trial of pulmonary vein isolation (PVI) versus PVI with posterior left atrial wall isolation (PWI) - The CAPLA study

    Pagina :210-220

    David Chieng, Hariharan Sugumar, Liang-Han Ling, Louise Segan, Sonia Azzopardi, Sandeep Prabhu, Ahmed Al-Kaisey, Aleksandr Voskoboinik, Ramanathan Parameswaran, Joseph B Morton, Bhupesh Pathik, Alex J McLellan, Geoffrey Lee, Michael Wong, Sue Finch, Rajeev K Pathak, Deep Chandh Raja, Prashanthan Sanders, Laurence Sterns, Matthew Ginks, Christopher M Reid, Jonathan M Kalman, Peter M Kistler

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• Review Articles

  • ·The COVID-19 pandemic and cardiovascular issues in clinical trials: Practical and regulatory issues in remote monitoring of cardiac safety

    Pagina :122-126

    Jonathan Seltzer, Fortunato Senatore, Ken Faulkner, Kenneth Martin Stein, Lt Stephen Browning, Polina Voloshko, Elektra J. Papadopoulos

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• Clinical Investigations

  • ·Relationship of ejection fraction and natriuretic peptide trajectories in heart failure with baseline reduced and mid-range ejection fraction

    Pagina :1-10

    Kenneth C. Bilchick, Patrick Stafford, Olusola Laja, Comfort Elumogo, Persey Bediako, Nora Tolbert, Douglas Sawch, Sthuthi David, Nishtha Sodhi, Anita Barber, Younghoon Kwon, Nishaki Mehta, Brandy Patterson, Khadijah Breathett, Sula Mazimba

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  • ·Population health management of low-density lipoprotein cholesterol via a remote, algorithmic, navigator-executed program

    Pagina :15-27

    Jorge Plutzky, Mark D. Benson, Kira Chaney, Tiffany V. Bui, Michael Kraft, Lina Matta, Marian McPartlin, David Zelle, Christopher P. Cannon, Anton Dodek, Thomas A. Gaziano, Akshay S. Desai, Calum A. MacRae, Benjamin M. Scirica

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  • ·In vivo evidence of atherosclerotic plaque erosion and healing in patients with acute coronary syndrome using serial optical coherence tomography imaging

    Pagina :66-76

    Yanwei Yin, Chao Fang, Senqing Jiang, Jifei Wang, Yidan Wang, Junchen Guo, Fangmeng Lei, Sibo Sun, Xueying Pei, Ruyi Jia, Lulu Li, Yini Wang, Huai Yu, Jiannan Dai, Bo Yu

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  • ·Effect of intensive versus limited monitoring on clinical trial conduct and outcomes: A randomized trial

    Pagina :77-86

    Neel M. Butala, Yang Song, Changyu Shen, David J. Cohen, Robert W. Yeh

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  • ·Trends in hospitalizations for heart failure, acute myocardial infarction, and stroke in the United States from 2004 to 2018

    Pagina :103-109

    Husam M. Salah, Abdul Mannan Khan Minhas, Muhammad Shahzeb Khan, Safi U. Khan, Andrew P. Ambrosy, Vanessa Blumer, Muthiah Vaduganathan, Stephen J. Greene, Ambarish Pandey, Marat Fudim

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  • ·Long-term outcomes in patients treated with flecainide for atrial fibrillation with stable coronary artery disease

    Pagina :127-139

    Tyson S. Burnham, Heidi T. May, Tami L. Bair, Jeffrey A. Anderson, Brian G. Crandall, Michael J. Cutler, John D. Day, Roger A. Freedman, Kirk U. Knowlton, Joseph B. Muhlestein, Leenhapong Navaravong, Ravi A. Ranjan, Benjamin A. Steinberg, T. Jared Bunch

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  • ·Temporal trends in utilization of transcatheter aortic valve replacement and patient characteristics: A nationwide study

    Pagina :140-146

    Jarl E. Strange, Caroline Sindet-Pedersen, Gunnar H. Gislason, Christian Torp-Pedersen, Kristian H. Kragholm, Camilla Lundahl, Emil L. Fosbøl, Jawad H. Butt, Lars Køber, Lars Søndergaard, Jonas B. Olesen

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  • ·Inhibition of p38 MAP kinase in patients with ST-elevation myocardial infarction – findings from the LATITUDE–TIMI 60 trial

    Pagina :147-157

    Matthew A Cavender, Michelle L. O'Donoghue, Antonio Abbate, Philip Aylward, Keith AA Fox, Ruchira X Glaser, Jeong-Gun Park, Jose Lopez-Sendon, Ph Gabriele Steg, Marc S Sabatine, David A Morrow

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  • ·Prevalent pharmacotherapy of US Fontan survivors: A study utilizing data from the MarketScan Commercial and Medicaid claims databases

    Pagina :158-166

    Michael L. O'Byrne, Jennifer A. Faerber, Hannah Katcoff, Jing Huang, Jonathan B. Edelson, David M. Finkelstein, Bethan A. Lemley, Christopher M. Janson, Catherine M. Avitabile, Andrew C. Glatz, David J. Goldberg

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  • ·Stopping renin-angiotensin system inhibitors after hyperkalemia and risk of adverse outcomes

    Pagina :177-186

    Yang Xu, Edouard L. Fu, Marco Trevisan, Tomas Jernberg, Arvid Sjölander, Catherine M Clase, Juan-Jesus Carrero

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  • ·Predictors of outcome in the ISCHEMIA-CKD trial: Anatomy versus ischemia

    Pagina :187-200

    Kevin R. Bainey, Jerome L. Fleg, Judith S. Hochman, Dennis F. Kunichoff, Rebecca Anthopolos, Alexander M. Chernyavskiy, Marcin Demkow, Juan-Manuel Lopez-Quijano, Jorge Escobedo, Kian Keong Poh, Ruben B. Ramos, Eduardo G. Lima, Herwig Schuchlenz, Ziad A. Ali, Gregg W. Stone, David J. Maron, Sean M. O'Brien, John A. Spertus, Sripal Bangalore

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  • ·Associations between neighborhood socioeconomic cluster and hypertension, diabetes, myocardial infarction, and coronary artery disease within a cohort of cardiac catheterization patients

    Pagina :201-209

    Anne M. Weaver, Laura A. McGuinn, Lucas Neas, Robert B. Devlin, Radhika Dhingra, Cavin K. Ward-Caviness, Wayne E. Cascio, William E. Kraus, Elizabeth R. Hauser, David Diaz-Sanchez

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  • ·The bleeding risk treatment paradox at the physician and hospital level: Implications for reducing bleeding in patients undergoing percutaneous coronary intervention

    Pagina :221-231

    Amit P. Amin, Nathan Frogge, Hemant Kulkarni, Gene Ridolfi, Gregory Ewald, Rachel Miller, Bruce Hall, Susan Rogers, Ty Gluckman, Jeptha Curtis, Frederick A. Masoudi, Sunil V. Rao

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  • ·Incidence rates and predictors of microvascular and macrovascular complications in patients with type 2 diabetes: Results from the longitudinal global discover study

    Pagina :232-239

    Suzanne V Arnold, Kamlesh Khunti, Fengming Tang, Hungta Chen, Javier Cid-Ruzafa, Andrew Cooper, Peter Fenici, Marilia B Gomes, Niklas Hammar, Linong Ji, Gabriela Luporini Saraiva, Jesús Medina, Antonio Nicolucci, Larisa Ramirez, Wolfgang Rathmann, Marina V Shestakova, Iichiro Shimomura, Filip Surmont, Jiten Vora, Hirotaka Watada, Mikhail Kosiborod

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• Research Letters

  • ·A global perspective of racial differences and outcomes in patients presenting with acute heart failure

    Pagina :11-14

    Jasper Tromp, Wouter Ouwerkerk, John G.F. Cleland, Chanchal Chandramouli, Christiane E. Angermann, Ulf Dahlstrom, Georg Ertl, Mahmoud Hassanein, Sergio V. Perrone, Mathieu Ghadanfar, Anja Schweizer, Achim Obergfell, Kenneth Dickstein, Sean P Collins, Gerasimos Filippatos, Carolyn SP Lam

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  • ·Impact of vomiting on P2Y12 platelet inhibition in patients with ST-elevation myocardial infarction: A prespecified subanalysis of the ON-TIME 3 trial

    Pagina :39-42

    Anne??H. Tavenier, Renicus??S. Hermanides, Jan??Paul. Ottervanger, Svetlana??V. Belitser, Olaf.??H. Klungel, Arnoud??W.J. van ‘t Hof, ON-TIME 3 investigators

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  • ·Trends in transcatheter and surgical aortic valve replacement in the United States, 2008-2018

    Pagina :87-91

    Katherine AA Clark, Fouad Chouairi, Bradley Kay, Samuel W Reinhardt, P Elliott Miller, Michael Fuery, Clancy W Mullan, Avirup Guha, Tariq Ahmad, Nihar R Desai

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