Sommario

• • ·Table of Contents

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• • ·Editorial Board

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• • ·Information for Readers

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• Curriculum in Cardiology

  • ·To Adjust or Not to Adjust: The Role of Different Covariates in Cardiovascular Observational Studies

    Pagina :62-67

    Mahyar Etminan, James M. Brophy, Gary Collins, Maryam Nazemipour, Mohammad Ali Mansournia

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• Trial Designs

  • ·Comparison of Outcomes with Midodrine and Fludrocortisone for Objective Recurrence in Treating Syncope (COMFORTS trial): Rationale and design for a multi-center randomized controlled trial

    Pagina :5-12

    Arya Aminorroaya, Hamed Tavolinejad, Saeed Sadeghian, Arash Jalali, Farshid Alaeddini, Zahra Emkanjoo, Reza Mollazadeh, Ali Bozorgi, Saeed Oraii, Mohamadreza Kiarsi, Javad Shahabi, Mohammad Ali Akbarzadeh, Behzad Rahimi, Adel Joharimoghadam, Abolfazl Mohsenizade, Roghayeh Mohammadi, Alireza Oraii, Hamid Ariannejad, Sanatcha Apakuppakul, Tachapong Ngarmukos, Masih Tajdini

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  • ·Effectiveness of the quadrivalent high-dose influenza vaccine for prevention of cardiovascular and respiratory events in people aged 65 years and above: Rationale and design of a real-world pragmatic randomized clinical trial

    Pagina :54-61

    Rosalind Hollingsworth, Arto Palmu, Stephanie Pepin, Martin Dupuy, Anju Shrestha, Jukka Jokinen, Ritva Syrjänen, Joshua Nealon, Sandrine Samson, Iris De Bruijn

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  • ·Rationale and design of the Women's Ischemia Trial to Reduce Events in Nonobstructive CAD (WARRIOR) trial

    Pagina :90-103

    Eileen M. Handberg, C. Noel Bairey Merz, Rhonda M. Cooper-Dehoff, Janet Wei, Michael Conlon, Margaret C. Lo, William Boden, Susan M. Frayne, Todd Villines, John A. Spertus, William Weintraub, Patrick O'Malley, Bernard Chaitman, Leslee J. Shaw, Matthew Budoff, Andre Rogatko, Carl J. Pepine

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  • ·A randomized prospective multicenter trial for stroke prevention by prophylactic surgical closure of the left atrial appendage in patients undergoing bioprosthetic aortic valve surgery––LAA-CLOSURE trial protocol

    Pagina :127-134

    Tuomas Kiviniemi, Juan Bustamante-Munguira, Christian Olsson, Anders Jeppsson, Frank R. Halfwerk, Juha Hartikainen, Piotr Suwalski, Igor Zindovic, Guillermo Reyes Copa, F.R.N. van Schaagen, Thorsten Hanke, Sergei Cebotari, Markus Malmberg, Mireia Fernandez-Gutierrez, Markus Bjurbom, Henrik Schersten, Ron Speekenbrink, Teemu Riekkinen, Danyal Ek, Tuija Vasankari, Gregory Y.H. Lip, K.E. Juhani Airaksinen, Bart van Putte, for the LAA-CLOSURE Investigators

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  • ·Design and rationale of the randomized trial of comprehensive lifestyle modification, optimal pharmacological treatment and utilizing PET imaging for quantifying and managing stable coronary artery disease (the CENTURY study)

    Pagina :135-146

    Danai Kitkungvan, Nils P. Johnson, Richard Kirkeeide, Mary Haynie, Catharine Carter, Monica B. Patel, Linh Bui, Mohammad Madjid, Patricia Mendoza, Amanda E. Roby, Susan Hood, Hongjian Zhu, Dejian Lai, Stefano Sdringola, Kenneth Lance Gould

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• Clinical Investigations

  • ·Randomized comparison of early supplemental oxygen versus ambient air in patients with confirmed myocardial infarction: Sex-related outcomes from DETO2X-AMI

    Pagina :13-24

    Joakim Alfredsson, Stefan K. James, David Erlinge, Johan Herlitz, Ole Fröbert, Christian Dworeck, Björn Redfors, Gabriel Arefalk, Ollie Östlund, Tomas Jernberg, Katarina Mars, Urban Haaga, Bertil Lindahl, Eva Swahn, Sofia Sederholm Lawesson, Robin Hofmann, for the DETO2X-SWEDEHEART Investigators

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  • ·Transcatheter aortic valve replacement in low-risk patients: 2-year results from the LRT trial

    Pagina :25-33

    Ron Waksman, Rebecca Torguson, Giorgio A. Medranda, Corey Shea, Cheng Zhang, Paul Gordon, Afshin Ehsan, Sean R. Wilson, Robert Levitt, Chiwon Hahn, Puja Parikh, Thomas Bilfinger, David Butzel, Scott Buchanan, Nicholas Hanna, Maurice Buchbinder, Federico Asch, Gaby Weissman, Itsik Ben-Dor, Christian Shults, Hector M. Garcia-Garcia, Lowell F. Satler, Toby Rogers

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  • ·Potent P2Y12 inhibitors versus Clopidogrel in elderly patients with acute coronary syndrome: Systematic review and meta-analysis

    Pagina :34-44

    Tomohiro Fujisaki, Toshiki Kuno, Tomo Ando, Alexandros Briasoulis, Hisato Takagi, Sripal Bangalore

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  • ·Natriuretic peptide plasma concentrations and risk of cardiovascular versus non-cardiovascular events in heart failure with reduced ejection fraction: Insights from the PARADIGM-HF and ATMOSPHERE trials

    Pagina :45-53

    Muhammad Shahzeb Khan, Soren Lund Kristensen, Muthiah Vaduganathan, Lars Kober, William T Abraham, Akshay S Desai, Scott D Solomon, Karl Swedberg, Kenneth Dickstein, Michael R Zile, Milton Packer, John JV. McMurray, Javed Butler

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  • ·Efficacy of a centralized, blended electronic, and human intervention to improve direct oral anticoagulant adherence: Smartphones to improve rivaroxaban ADHEREnce in atrial fibrillation (SmartADHERE) a randomized clinical trial

    Pagina :68-78

    Mintu Turakhia, Vandana Sundaram, Shea N. Smith, Victoria Ding, P. Michael Ho, Peter R. Kowey, Jonathan P. Piccini, JoAnne Foody, Mary C. Birmingham, Juliana Ianus, Amol Rajmane, Kenneth W. Mahaffey, the smartADHERE Investigators

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  • ·Effect of a smartphone-based intervention on secondary prevention medication prescriptions after coronary artery bypass graft surgery: The MISSION-1 randomized controlled trial

    Pagina :79-89

    Jianyu Qu, Junzhe Du, Chenfei Rao, Sipeng Chen, Dachuan Gu, Jing Li, Heng Zhang, Yan Zhao, Shengshou Hu, Zhe Zheng, for the MISSION-1 Collaborative Group

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  • ·Renin-angiotensin system inhibitors effect before and during hospitalization in COVID-19 outcomes: Final analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry

    Pagina :104-115

    Iván J. Núñez-Gil, Iván Olier, Gisela Feltes, María C. Viana-Llamas, Charbel Maroun-Eid, Rodolfo Romero, Inmaculada Fernández-Rozas, Aitor Uribarri, Victor M. Becerra-Muñoz, Emilio Alfonso-Rodriguez, Marcos García-Aguado, Javier Elola, Alex Castro-Mejía, Martino Pepe, Juan Fortunato Garcia-Prieto, Adelina Gonzalez, Fabrizio Ugo, Enrico Cerrato, Elvira Bondia, Sergio Raposeiras-Roubin, Jorge L. Jativa Mendez, Carolina Espejo, Álvaro López-Masjuan, Francisco Marin, Javier López-Pais, Mohammad Abumayyaleh, Miguel Corbi-Pascual, Christoph Liebetrau, Harish Ramakrishna, Vicente Estrada, Carlos Macaya, Antonio Fernandez-Ortiz, HOPE COVID-19 Investigators (Cols Appendix)

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  • ·Sex disparities in patients with symptomatic severe aortic stenosis

    Pagina :116-126

    Angela Lowenstern, Paige Sheridan, Tracy Y. Wang, Isabel Boero, Sreekanth Vemulapalli, Vinod H. Thourani, Martin B. Leon, Eric D. Peterson, J. Matthew Brennan

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• Research Letters

  • ·Venous thromboembolism among patients hospitalized with COVID-19 at Veterans Health Administration Hospitals

    Pagina :1-4

    J. Antonio Gutierrez, Marc D. Samsky, Ryan D. Schulteis, Lin Gu, Rajesh V. Swaminathan, Aaron W. Aday, Sunil V. Rao

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