Sommario

• • ·Table of Contents

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• • ·Editorial Board

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• • ·Information for Readers

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• Cardiac Safety Research Consortium

  • ·Assessing cardiac safety in oncology drug development

    Pagina :125-133

    Jonathan H Seltzer, Gary Gintant, Laleh Amiri-Kordestani, Jack Singer, Luana Pesco Koplowitz, Javid J Moslehi, Ana Barac, Anthony F. Yu

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• Trial Designs

  • ·Hemodynamic-GUIDEd management of Heart Failure (GUIDE-HF)

    Pagina :18-27

    JoAnn Lindenfeld, William T. Abraham, Alan Maisel, Michael Zile, Frank Smart, Maria Rosa Costanzo, Mandeep R. Mehra, Anique Ducharme, Samuel F. Sears, Akshay S. Desai, Sara Paul, Poornima Sood, Nessa Johnson, Greg Ginn, Philip B. Adamson

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  • ·Ablation versus Anti-Arrhythmic Therapy for Reducing All Hospital Episodes from Recurrent Atrial Fibrillation (AVATAR-AF): Design and rationale

    Pagina :36-45

    Ian Mann, Thiagarajah Sasikaran, Belinda Sandler, Daphne Babalis, Nicholas Johnson, Emanuela Falaschetti, Andrew Copley, Muzahir Tayebjee, Derick Todd, Ewen Shepherd, James McCready, Neil Poulter, Prapa Kanagaratnam

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  • ·Rationale and design of DanGer shock: Danish-German cardiogenic shock trial

    Pagina :60-68

    Nanna Junker Udesen, Jacob Eifer Møller, Matias Greve Lindholm, Hans Eiskjær, Andreas Schäfer, Nikos Werner, Lene Holmvang, Christian Juhl Terkelsen, Lisette Okkels Jensen, Anders Junker, Henrik Schmidt, Kristian Wachtell, Holger Thiele, Thomas Engstrøm, Christian Hassager, DanGer Shock investigators

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  • ·Spironolactone and perioperative atrial fibrillation occurrence in cardiac surgery patients: Rationale and design of the ALDOCURE trial

    Pagina :88-96

    Joachim Alexandre, Pierre Ollitrault, Marc-Olivier Fischer, Jean-Luc Fellahi, Bertrand Rozec, Bernard Cholley, Charles Dolladille, Mathieu Chequel, Stéphane Allouche, Damien Legallois, Vladimir Saplacan, Dimitrios Buklas, Farzin Beygui, Jean-Jacques Parienti, Paul Milliez

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  • ·Rational and design of the INtentional COronary revascularization versus conservative therapy in patients undergOing successful peripheRAl arTEry revascularization due to critical limb ischemia trial (INCORPORATE trial)

    Pagina :107-112

    G. Toth, Marianne Brodmann, Emanuele Barbato, Fabio Mangiacapra, Laura Schneller, Viktor Orias, Robert Gil, Jacek Bil, Stanislaw Bartus, Zoltan Ruzsa

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  • ·Rationale and design of the Onyx ONE global randomized trial: A randomized controlled trial of high-bleeding risk patients after stent placement with 1?month of dual antiplatelet therapy

    Pagina :134-141

    Elvin Kedhi, Azeem Latib, Alexandre Abizaid, David Kandzari, Ajay J. Kirtane, Roxana Mehran, Matthew J. Price, Daniel Simon, Stephen Worthley, Azfar Zaman, Sandeep Brar, Minglei Liu, Gregg W. Stone, Stephan Windecker

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  • ·Rationale and design of the PRAETORIAN-DFT trial: A prospective randomized CompArative trial of SubcutanEous ImplanTable CardiOverter-DefibrillatoR ImplANtation with and without DeFibrillation testing

    Pagina :167-174

    Anne-Floor B.E. Quast, Sarah W.E. Baalman, Tim R. Betts, Lucas V.A. Boersma, Hendrik Bonnemeier, Serge Boveda, Tom F. Brouwer, Martin C. Burke, Peter Paul H.M. Delnoy, Mikhael El-Chami, Juergen Kuschyk, Pier Lambiase, Christelle Marquie, Marc A. Miller, Lonneke Smeding, Arthur A.M. Wilde, Reinoud E. Knops

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  • ·Canadian-Australasian Randomised trial of screening kidney transplant candidates for coronary artery disease—A trial protocol for the CARSK study

    Pagina :175-183

    Tracey Ying, Jagbir Gill, Angela Webster, S. Joseph Kim, Rachael Morton, Scott W. Klarenbach, Patrick Kelly, Timothy Ramsay, Gregory A. Knoll, Helen Pilmore, Gillian Hughes, Charles A. Herzog, Steven Chadban, John S. Gill

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• Trial Design Update

  • ·A protocol update of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) 3 trial: A comparison of fractional flow reserve–guided percutaneous coronary intervention and coronary artery bypass graft surgery in patients with multivessel coronary artery disease

    Pagina :156-157

    Frederik M. Zimmermann, Bernard De Bruyne, Nico H.J. Pijls, Manisha Desai, Keith G. Oldroyd, Michael J. Reardon, Olaf Wendler, Joseph Woo, Alan C. Yeung, William F. Fearon

    

• Special Articles

  • ·Objective Randomised Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina (ORBITA) and coronary stents: A case study in the analysis and reporting of clinical trials

    Pagina :54-59

    Andrew Gelman, John B. Carlin, Brahmajee K. Nallamothu

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• Clinical Investigations

  • ·De-escalation of antianginal medications after successful chronic total occlusion percutaneous coronary intervention: Frequency and relationship with health status

    Pagina :1-8

    Mohammed Qintar, Taishi Hirai, Suzanne V. Arnold, Justin Sheehy, James Sapontis, Phil Jones, Yuanyuan Tang, William Lombardi, Dimitri Karmpaliotis, Jeffery Moses, Christian Patterson, William J. Nicholson, David J. Cohen, John A. Spertus, J. Aaron Grantham, Adam C. Salisbury

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  • ·Outcomes of left main revascularization in patients with acute coronary syndromes and stable ischemic heart disease: Analysis from the EXCEL trial

    Pagina :9-17

    Serge Doucet, E. Marc Jolicœur, Patrick W. Serruys, Michael Ragosta, Irving L. Kron, Werner Scholtz, Jochen Börgermann, Yiran Zhang, Thomas McAndrew, Joseph F. Sabik, Arie Pieter Kappetein, Gregg W. Stone

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  • ·Participation in thrill-seeking activities by patients with hypertrophic cardiomyopathy: Individual preferences, adverse events and physician attitude

    Pagina :28-35

    Nikolaos Papoutsidakis, Stephen Heitner, Jodie Ingles, Christopher Semsarian, Meghan Mannello, Lisa Salberg, Cynthia Waldman, Benjamin Vaccaro, Niccolo Maurizi, Iacopo Olivotto, Daniel Jacoby

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  • ·Racial differences in long-term outcomes among black and white patients with drug-eluting stents

    Pagina :46-53

    Lonnie T. Sullivan, Hillary Mulder, Karen Chiswell, Linda K. Shaw, Tracy Y. Wang, Larry R. Jackson, Kevin L. Thomas

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  • ·Risk factors and prognostic impact of left ventricular assist device–associated infections

    Pagina :69-76

    Pierre Tattevin, Erwan Flécher, Vincent Auffret, Christophe Leclercq, Stéphane Boulé, André Vincentelli, Camille Dambrin, Clément Delmas, Laurent Barandon, Vincent Veniard, Michel Kindo, Thomas Cardi, Philippe Gaudard, Philippe Rouvière, Thomas Sénage, Nicolas Jacob, Pascal Defaye, Olivier Chavanon, Constance Verdonk, Marylou Para, Edeline Pelcé, Vlad Gariboldi, Matteo Pozzi, Daniel Grinberg, Arnaud Savouré, Pierre-Yves Litzler, Gerard Babatasi, Annette Belin, Fabien Garnier, Marie Bielefeld, David Hamon, Nicolas Lellouche, Louis Bernard, Thierry Bourguignon, Romain Eschalier, Nicolas D'Ostrevy, Jérôme Jouan, Emilie Varlet, Fabrice Vanhuyse, Hugues Blangy, Raphaël P. Martins, Vincent Galand

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  • ·Modeling the cost effectiveness and budgetary impact of Polypills for secondary prevention of cardiovascular disease in the United States

    Pagina :77-87

    Thomas A. Gaziano, Ankur Pandya, Stephen Sy, Thiago Veiga Jardim, Jenna M. Ogden, Anthony Rodgers, Milton C. Weinstein

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  • ·Twenty-year trends in profile, management and outcomes of patients with ST-segment elevation myocardial infarction according to use of reperfusion therapy: Data from the FAST-MI program 1995-2015

    Pagina :97-106

    Etienne Puymirat, Guillaume Cayla, Yves Cottin, Meyer Elbaz, Patrick Henry, Edouard Gerbaud, Gilles Lemesle, Batric Popovic, Jean-Noel Labèque, François Roubille, Stéphane Andrieu, Bruno Farah, François Schiele, Jean Ferrières, Tabassome Simon, Nicolas Danchin

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  • ·Practice-level variation in statin use and low-density lipoprotein cholesterol control in the United States: Results from the Patient and Provider Assessment of Lipid Management (PALM) registry

    Pagina :113-124

    Michael G. Nanna, Ann Marie Navar, Tracy Y. Wang, Shuang Li, Salim S. Virani, Zhuokai Li, Jennifer G. Robinson, Veronique L. Roger, Peter W.F. Wilson, Anne C. Goldberg, Andrew Koren, Michael J. Louie, Eric D. Peterson

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  • ·Creatinine versus cystatin C to estimate glomerular filtration rate in adults with congenital heart disease: Results of the Boston Adult Congenital Heart Disease Biobank

    Pagina :142-155

    Alexander R. Opotowsky, Matthew Carazo, Michael N. Singh, Konstantinos Dimopoulos, David A. Cardona-Estrada, Ahmed Elantably, Sushrut S. Waikar, Finnian R. Mc Causland, Gruschen Veldtman, Jasmine Grewal, Catherine Gray, Brittani N. Loukas, Saurabh Rajpal

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  • ·Role of diabetes and insulin use in the risk of stroke and acute myocardial infarction in patients with atrial fibrillation: A Medicare analysis

    Pagina :158-166

    Amgad Mentias, Ghanshyam Shantha, Oluwaseun Adeola, Geoffrey D Barnes, Bharat Narasimhan, Konstantinos C. Siontis, Deborah A. Levine, Rajan Sah, Michael C. Giudici, Mary Vaughan Sarrazin

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  • ·Hospital participation in clinical trials for patients with acute myocardial infarction: Results from the National Cardiovascular Data Registry

    Pagina :184-193

    Alexander C. Fanaroff, Amit N. Vora, Anita Y. Chen, Robin Mathews, Jacob A. Udell, Matthew T. Roe, Laine E. Thomas, Tracy Y. Wang

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