Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :A5

    
• • ·Table of Contents

    Pagina :A8

    
• • ·Editorial Board

    Pagina :A41

    

• Reader services

  • ·Information for Readers

    Pagina :A42

    
  • ·News & Notes-AAAAI

    Pagina :A46

    Mappa Mappa
  • ·CME Calendar-AAAAI

    Pagina :A53

    

• Reviews and feature articles

  • ·Trained innate immunity: Concept, nomenclature, and future perspectives

    Pagina :1079-1084

    Mihai G. Netea, Leo A.B. Joosten

    Riassunto Riassunto Mappa Mappa  
  • ·Trained immunity–based vaccines for infections and allergic diseases

    Pagina :1085-1094

    Leticia Martín-Cruz, Cristina Benito-Villalvilla, Alba Angelina, José Luis Subiza, Oscar Palomares

    Riassunto Riassunto Mappa Mappa  
  • ·Deconstructing inflammatory memory across tissue set points using cell circuit motifs

    Pagina :1095-1105

    Andrew C. Kwong, Jose Ordovas-Montanes

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors’ Choice

    Pagina :1106-1110

    Mappa Mappa  

• News beyond our pages

  • ·News beyond our pages

    Pagina :1111-1113

    Mappa Mappa  

• Paradigms and perspectives

  • ·Central trained immunity and its impact on chronic inflammatory and autoimmune diseases

    Pagina :1113-1116

    George Hajishengallis, Triantafyllos Chavakis

    Mappa Mappa  
  • ·Mechanisms involved in the transmission of trained immunity to offspring

    Pagina :1117-1119

    Elisabeth A. Dulfer, Jorge Domínguez-Andrés

    Mappa Mappa  
  • ·Mucosal trained immunity–based vaccines: Cutting recurrent infections in autoimmune patients on immunosuppression

    Pagina :1120-1122

    Gloria Candelas, Ángela Villegas, Silvia Sánchez-Ramón

     
  • ·The processed milk hypothesis: A major factor in the development of eosinophilic esophagitis (EoE)?

    Pagina :1123-1126

    James R. Baker, Roopesh Singh Gangwar, Thomas A. Platts-Mills

    Mappa Mappa  

• Editorial

  • ·Why EoE is different: Liminality and parent-reported outcomes in food allergy

    Pagina :1127-1128

    Paul J. Turner

     

• Asthma and lower airway disease

  • ·IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity in asthma

    Pagina :1129-1145

    Fabian Bick, Claudia M. Brenis Gómez, Inés Lammens, Justine Van Moorleghem, Caroline De Wolf, Sam Dupont, Laure Dumoutier, Neal P. Smith, Alexandra-Chloé Villani, Robin Browaeys, Jehan Alladina, Alexis M. Haring, Benjamin D. Medoff, Josalyn L. Cho, René Bigirimana, Joao Vieira, Hamida Hammad, Christophe Blanchetot, Martijn J. Schuijs, Bart N. Lambrecht

    Riassunto Riassunto Mappa Mappa   
  • ·Airway proteomics reveals broad residual anti-inflammatory effects of prednisolone in mepolizumab-treated asthma

    Pagina :1146-1158

    Imran Howell, Freda Yang, Vanessa Brown, Jennifer Cane, Emanuele Marchi, Adnan Azim, John Busby, Pamela J. McDowell, Sarah E. Diver, Catherine Borg, Liam G. Heaney, Ian D. Pavord, Christopher E. Brightling, Rekha Chaudhuri, Timothy S.C. Hinks

    Riassunto Riassunto Mappa Mappa   
  • ·Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining

    Pagina :1159-1168

    Kyung Hwa Jung, Kira L. Argenio, Daniel J. Jackson, Rachel L. Miller, Matthew S. Perzanowski, Andrew G. Rundle, Leonard B. Bacharier, William W. Busse, Robyn T. Cohen, Cynthia M. Visness, Michelle A. Gill, Rebecca S. Gruchalla, Gurjit K. Hershey, Rachel K. Kado, Michael G. Sherenian, Andrew H. Liu, Melanie M. Makhija, Dinesh K. Pillai, Katherine Rivera-Spoljaric, Peter J. Gergen, Matthew C. Altman, Megan T. Sandel, Christine A. Sorkness, Meyer Kattan, Stephanie Lovinsky-Desir

    Riassunto Riassunto Mappa Mappa   

• Rhinitis, sinusitis, and ocular allergy

  • ·Allergic fungal rhinosinusitis linked to other hyper-IgE syndromes through defective T_H17 responses

    Pagina :1169-1179

    Hua Sun, J. Morgan Knight, Yi-Dong Li, Faramarz Ashoori, Martin J. Citardi, William C. Yao, David B. Corry, Amber U. Luong

    Riassunto Riassunto Mappa Mappa   
  • ·An in vitro study of the impact of IL-17A and IL-22 on ciliogenesis in nasal polyps epithelium via the Hippo-YAP pathway

    Pagina :1180-1194

    Huijun Qiu, Jing Liu, Qingwu Wu, Hsiaohui Ong, Yana Zhang, Xuekun Huang, Tian Yuan, Rui Zheng, Huiyi Deng, Weihao Wang, Weifeng Kong, Xinyue Wang, Deyun Wang, Qintai Yang

    Riassunto Riassunto Mappa Mappa   

• Atopic dermatitis and inflammatory skin disease

  • ·Comparative safety of oral Janus kinase inhibitors versus dupilumab in patients with atopic dermatitis: A population-based cohort study

    Pagina :1195

    Serena Yun-Chen Tsai, Wanda Phipatanakul, Elena B. Hawryluk, Michiko K. Oyoshi, Lynda C. Schneider, Kevin Sheng-Kai Ma

    Riassunto Riassunto Mappa Mappa  
  • ·Disease heterogeneity and molecular classification of inflammatory palmoplantar diseases

    Pagina :1204

    Kelsey R. van Straalen, Joseph Kirma, Christine M. Yee, Luke F. Bugada, Syed M. Rizvi, Fei Wen, Rachael Wasikowski, Jennifer Fox, Tran H. Do, Charles F. Schuler, Enze Xing, Amanda S. MacLeod, Paul W. Harms, Celine C. Berthier, J. Michelle Kahlenberg, Monica W.L. Leung, Lam C. Tsoi, Johann E. Gudjonsson

    Riassunto Riassunto Mappa Mappa  
  • ·Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders

    Pagina :1216-1231

    Joseph Daccache, Eunsuh Park, Muhammad Junejo, Mariam Abdelghaffar, Erica Hwang, Chitrasen Mohanty, Chandra K. Singh, Guilin Wang, John O. Wheeler, Bridget E. Shields, Caroline A. Nelson, Yiwei Wang, William Damsky

    Riassunto Riassunto Mappa Mappa   

• Food allergy and gastrointestinal disease

  • ·Long-term durability between parent and child patient-reported outcomes in eosinophilic esophagitis

    Pagina :1232

    Lisa J. Martin, Xue Zhang, Mirna Chehade, Carla M. Davis, Evan S. Dellon, Gary W. Falk, Sandeep K. Gupta, Ikuo Hirano, Girish S. Hiremath, David A. Katzka, Paneez Khoury, John Leung, Paul Menard-Katcher, Nirmala Gonsalves, Robert D. Pesek, Jonathan M. Spergel, Joshua B. Wechsler, Kara Kliewer, Nicoleta C. Arva, Margaret H. Collins, Maria Pletneva, Guang-Yu Yang, Glenn T. Furuta, Marc E. Rothenberg, Seema S. Aceves

    Riassunto Riassunto Mappa Mappa  
  • ·Preclinical efficacy of peanut-specific IgG4 antibody therapeutic IGNX001

    Pagina :1241

    Derek Croote, Joyce J.W. Wong, Paige Creeks, Venu Aruva, Jeffrey J. Landers, Matthew Kwok, Zainab Jama, Robert G. Hamilton, Alexandra F. Santos, Jessica J. O’Konek, Roger Ferrini, G. Roger Thomas, Henry B. Lowman

    Riassunto Riassunto Mappa Mappa  
  • ·Utility of epitope-specific IgE, IgG4, and IgG1 antibodies for the diagnosis of wheat allergy

    Pagina :1249-1259

    Witchaya Srisuwatchari, Mayte Suárez-Fariñas, Andrew D. Delgado, Galina Grishina, Maria Suprun, Ashley Sang Eun Lee, Pakit Vichyanond, Punchama Pacharn, Hugh A. Sampson

    Riassunto Riassunto Mappa Mappa   

• Mechanisms of allergy/immunology

  • ·Microbial intestinal dysbiosis drives long-term allergic susceptibility by sculpting an ILC2–B1 cell–innate IgE axis

    Pagina :1260

    Ahmed Kabil, Natalia Nayyar, Julyanne Brassard, Yicong Li, Sameeksha Chopra, Michael R. Hughes, Kelly M. McNagny

    Riassunto Riassunto Mappa Mappa  
  • ·Multiomics analysis identified IL-4–induced IL1RL1^high eosinophils characterized by prominent cysteinyl leukotriene metabolism

    Pagina :1277-1288

    Keeya Sunata, Jun Miyata, Yusuke Kawashima, Ryo Konno, Masaki Ishikawa, Yoshinori Hasegawa, Ryuta Onozato, Yo Otsu, Emiko Matsuyama, Hisashi Sasaki, Shinichi Okuzumi, Takao Mochimaru, Katsunori Masaki, Hiroki Kabata, Akihiko Kawana, Makoto Arita, Koichi Fukunaga

    Riassunto Riassunto Mappa Mappa   
  • ·Nonspecific lipid-transfer proteins trigger TLR2 and NOD2 signaling and undergo ligand-dependent endocytosis in epithelial cells

    Pagina :1289-1299

    Nicola Cavallari, Alexander Johnson, Christoph Nagl, Saskia Seiser, Gerald N. Rechberger, Thomas Züllig, Thomas A. Kufer, Adelheid Elbe-Bürger, Sabine Geiselhart, Karin Hoffmann-Sommergruber

    Riassunto Riassunto Mappa Mappa   

• Translational and clinical immunology

  • ·Human DNA-dependent protein kinase catalytic subunit deficiency: A comprehensive review and update

    Pagina :1300-1312

    Jihane Adelon, Hassan Abolhassani, Saliha Esenboga, Fanny Fouyssac, Deniz Cagdas, Ilhan Tezcan, Barıs Kuskonmaz, Duygu Cetinkaya, Felipe Suarez, Seyed Alireza Mahdaviani, Samira Plassart, Anne-Laure Mathieu, Nicole Fabien, Christophe Malcus, Florence Morfin-Sherpa, Geneviève Billaud, Maud Tusseau, Sarah Benezech, Thierry Walzer, Jean-Pierre De Villartay, Yves Bertrand, Alexandre Belot

    Riassunto Riassunto Mappa Mappa   
  • ·Variants in IGLL1 cause a broad phenotype from agammaglobulinemia to transient hypogammaglobulinemia

    Pagina :1313

    Maarja Soomann, Viktor Bily, Magdeldin Elgizouli, Dennis Kraemer, Gülfirde Akgül, Horst von Bernuth, Markéta Bloomfield, Nicholas Brodszki, Fabio Candotti, Elisabeth Förster-Waldl, Tomas Freiberger, Maria Giżewska, Adam Klocperk, Uwe Kölsch, Kim E. Nichols, Renate Krüger, Ninad Oak, Małgorzata Pac, Seraina Prader, Kjeld Schmiegelow, Anna Šedivá, Georgios Sogkas, Anna Stittrich, Ulrik Kristoffer Stoltze, Katerina Theodoropoulou, Karin Wadt, Melanie Wong, Maximillian Zeyda, Jana Pachlopnik Schmid, Johannes Trück

    Riassunto Riassunto Mappa Mappa  

• Brief reports

  • ·T_H2 cell compensatory effect following benralizumab treatment for eosinophilic gastritis

    Pagina :1325

    Netali Ben-Baruch Morgenstern, Yrina Rochman, Julie M. Caldwell, Margaret H. Collins, Vincent A. Mukkada, Philip E. Putnam, Scott M. Bolton, Kara L. Kliewer, Marc E. Rothenberg

    Riassunto Riassunto Mappa Mappa  
  • ·Dupilumab treatment decreases MBC2s, correlating with reduced IgE levels in pediatric atopic dermatitis

    Pagina :1333

    Margot E. Starrenburg, Manal Bel Imam, Juan F. Lopez, Laura Buergi, N. Tan Nguyen, Anouk E.M. Nouwen, Nicolette J.T. Arends, Peter J. Caspers, Mübeccel Akdis, Suzanne G.M.A. Pasmans, Willem van de Veen

    Riassunto Riassunto Mappa Mappa  
  • ·Beyond IL-5 inhibition for the treatment of episodic angioedema with eosinophilia (Gleich syndrome)

    Pagina :1339-1340

    Emmanuel Ledoult, Matthieu Groh, Jean-Emmanuel Kahn, Guillaume Lefevre

    
  • ·Mepolizumab for episodic angioedema with eosinophilia

    Pagina :1340-1341

    Matthew A. Rank

    
  • ·Reply

    Pagina :1341

    Paneez Khoury, Michelle Makiya, Amy D. Klion

    
  • ·Corrigendum

    Pagina :1342