Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :A5

    
• • ·Table of Contents

    Pagina :A8

    
• • ·Editorial Board

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• Reader services

  • ·Information for Readers

    Pagina :A32

    
  • ·News & Notes

    Pagina :A34

    Mappa Mappa
  • ·CME Calendar-AAAAI

    Pagina :A37

    

• Reviews and feature articles

  • ·Urticarial vasculitis: Clinical and laboratory findings with a particular emphasis on differential diagnosis

    Pagina :1137-1149

    Angelo Valerio Marzano, Carlo Alberto Maronese, Giovanni Genovese, Silvia Ferrucci, Chiara Moltrasio, Riccardo Asero, Massimo Cugno

    Riassunto Riassunto Mappa Mappa  
  • ·Insights into hidradenitis suppurativa

    Pagina :1150-1161

    Kelsey R. van Straalen, Errol P. Prens, Johann E. Gudjonsson

    Riassunto Riassunto Mappa Mappa  
  • ·Novel insights into contact dermatitis

    Pagina :1162-1171

    Jeanne Duus Johansen, Charlotte Menné Bonefeld, Jakob Ferløv Baselius Schwensen, Jacob Pontoppidan Thyssen, Wolfgang Uter

    Riassunto Riassunto Mappa Mappa  
  • ·T cells in the skin: Lymphoma and inflammatory skin disease

    Pagina :1172-1184

    Ben Roediger, Christoph Schlapbach

    Riassunto Riassunto Mappa Mappa  
  • ·Atopic dermatitis and pregnancy

    Pagina :1185-1194

    Galina Balakirski, Natalija Novak

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• The Editors' choice

  • ·The Editors’ Choice

    Pagina :1195-1200

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :1201-1202

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Neutrophils in neutrophilic dermatoses: Emerging roles and promising targeted therapies

    Pagina :1203-1205

    Shuai Shao, Ke Xue, Gang Wang

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  • ·Recognizing photoallergy, phototoxicity, and immune-mediated photodermatoses

    Pagina :1206-1209

    Linna L. Guan, Henry W. Lim, Tasneem F. Mohammad

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• Editorials

  • ·Understanding immune profiles in ichthyosis may lead to novel therapeutic targets

    Pagina :1210-1212

    Masashi Akiyama

     
  • ·Reversal of the disease signature in prurigo nodularis by blocking the itch cytokine

    Pagina :1213-1215

    Enikö Sonkoly

     
  • ·Exercise-induced laryngeal obstruction: A step in the right direction

    Pagina :1216-1217

    William D. Hardie, Carolyn M. Kercsmar

     
  • ·Caspase 8 sounds the alarm for allergic inflammation

    Pagina :1218-1220

    Xueping Zhu, Caroline L. Sokol

     
  • ·Structural insights into MRGPRX2: A new vision of itch and allergy

    Pagina :1221-1222

    Anna M. Trier, Brian S. Kim

     

• COVID-19

  • ·Profiling natural killers in COVID-19

    Pagina :1223-1224

    Emily M. Mace

     
  • ·Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19–convalescent individuals

    Pagina :1225-1241

    Min Li, Jiaojiao Liu, Renfei Lu, Yuchao Zhang, Meng Du, Man Xing, Zhenchuan Wu, Xiangyin Kong, Yufei Zhu, Xianchao Zhou, Landian Hu, Chiyu Zhang, Dongming Zhou, Xia Jin

    Riassunto Riassunto Mappa Mappa   
  • ·Comparative analyses of IgG/IgA neutralizing effects induced by three COVID-19 vaccines against variants of concern

    Pagina :1242

    Eliott Lafon, Michael Jäger, Angelika Bauer, Markus Reindl, Rosa Bellmann-Weiler, Doris Wilflingseder, Cornelia Lass-Flörl, Wilfried Posch

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• Asthma and lower airway disease

  • ·A unique population of neutrophils generated by air pollutant–induced lung damage exacerbates airway inflammation

    Pagina :1253

    Jae Woo Shin, Jihyun Kim, Seokjin Ham, Sun Mi Choi, Chang-Hoon Lee, Jung Chan Lee, Ji Hyung Kim, Sang-Heon Cho, Hye Ryun Kang, You-Me Kim, Doo Hyun Chung, Yeonseok Chung, Yoe-Sik Bae, Yong-Soo Bae, Tae-Young Roh, Taesoo Kim, Hye Young Kim

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  • ·Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma

    Pagina :1270-1280

    James W. Pinkerton, Richard Y. Kim, Alexandra C. Brown, Brittany E. Rae, Chantal Donovan, Jemma R. Mayall, Olivia R. Carroll, Md. Khadem Ali, Hayley A. Scott, Bronwyn S. Berthon, Katherine J. Baines, Malcolm R. Starkey, Nazanin Z. Kermani, Yi-Ke Guo, Avril A.B. Robertson, Luke A.J. O’Neill, Ian M. Adcock, Matthew A. Cooper, Peter G. Gibson, Lisa G. Wood, Philip M. Hansbro, Jay C. Horvat

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  • ·Severe bronchiolitis profiles and risk of asthma development in Finnish children

    Pagina :1281

    Orianne Dumas, Riku Erkkola, Eija Bergroth, Kohei Hasegawa, Jonathan M. Mansbach, Pedro A. Piedra, Tuomas Jartti, Carlos A. Camargo

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• Rhinitis, sinusitis, and ocular allergy

  • ·Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis

    Pagina :1286-1295

    Paul Oykhman, Fernando Aleman Paramo, Jean Bousquet, David W. Kennedy, Romina Brignardello-Petersen, Derek K. Chu

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  • ·Inflammatory molecular endotypes of nasal polyps derived from White and Japanese populations

    Pagina :1296

    Tsuguhisa Nakayama, Ivan T. Lee, Wei Le, Yasuhiro Tsunemi, Nicole A. Borchard, David Zarabanda, Sachi S. Dholakia, Philip A. Gall, Angela Yang, Dayoung Kim, Makoto Akutsu, Takashi Kashiwagi, Zara M. Patel, Peter H. Hwang, Daniel N. Frank, Shin-ichi Haruna, Vijay R. Ramakrishnan, Garry P. Nolan, Sizun Jiang, Jayakar V. Nayak

    Riassunto Riassunto Mappa Mappa  
  • ·Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: A randomized, placebo-controlled trial

    Pagina :1309

    Claus Bachert, Joseph K. Han, Martin Y. Desrosiers, Philippe Gevaert, Enrico Heffler, Claire Hopkins, Jody R. Tversky, Peter Barker, David Cohen, Claire Emson, Ubaldo J. Martin, Vivian H. Shih, Sofia Necander, James L. Kreindler, Maria Jison, Viktoria Werkström

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• Atopic dermatitis and inflammatory skin disease

  • ·Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers

    Pagina :1318-1328

    Emma Guttman-Yassky, Ana B. Pavel, Aisleen Diaz, Ning Zhang, Ester Del Duca, Yeriel Estrada, Brett King, Anindita Banerjee, Christopher Banfield, Lori Ann Cox, Martin E. Dowty, Karen Page, Michael S. Vincent, Weidong Zhang, Linda Zhu, Elena Peeva

    Riassunto Riassunto Mappa Mappa   
  • ·Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab

    Pagina :1329-1339

    Lam C. Tsoi, Feriel Hacini-Rachinel, Paul Fogel, Francois Rousseau, Xianying Xing, Matthew T. Patrick, Allison C. Billi, Celine C. Berthier, J. Michelle Kahlenberg, Anne Lazzari, Henning Wiegmann, Sonja Ständer, Christophe Piketty, Valerie Julia, Jayendra Kumar Krishnaswamy, Johann E. Gudjonsson

    Riassunto Riassunto Mappa Mappa   
  • ·Asivatrep, a TRPV1 antagonist, for the topical treatment of atopic dermatitis: Phase 3, randomized, vehicle-controlled study (CAPTAIN-AD)

    Pagina :1340

    Chun Wook Park, Beom Joon Kim, Yang Won Lee, Chonghyun Won, Chang Ook Park, Bo Young Chung, Dong Hun Lee, Kyoungmi Jung, Hyun-Jin Nam, Gyeyoung Choi, Young-Ho Park, Kyu Han Kim, Miyoung Park

    Riassunto Riassunto Mappa Mappa  
  • ·Ca_v1.4 calcium channels control cytokine production by human peripheral T_H17 cells and psoriatic skin-infiltrating T cells

    Pagina :1348-1357

    Marion Mars, Isabelle Néant, Catherine Leclerc, Stéphanie Bosch, Christian Rouviere, Marc Moreau, Simon Lachambre, Carle Paul, Marie Tauber, Eléonore Gravier, Clara Douzal, Hélène Duplan, Marine Babin, Alexia Brocario, Marie-Dominique Thouvenin, Jean-Charles Guéry, Daniel Redoules, Fabrice Lestienne, Lucette Pelletier, Magali Savignac

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  • ·Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α and allergic responses

    Pagina :1358-1372

    Claire Barbieux, Mathilde Bonnet des Claustres, Matthias Fahrner, Evgeniya Petrova, Lam C. Tsoi, Olivier Gouin, Florent Leturcq, Pascale Nicaise-Roland, Christine Bole, Vivien Béziat, Emmanuelle Bourrat, Oliver Schilling, Johann E. Gudjonsson, Alain Hovnanian

    Riassunto Riassunto Mappa Mappa   

• Food allergy and gastrointestinal disease

  • ·Allergen-specific T cells and clinical features of food allergy: Lessons from CoFAR immunotherapy cohorts

    Pagina :1373

    M. Cecilia Berin, Charuta Agashe, A. Wesley Burks, David Chiang, Wendy F. Davidson, Peter Dawson, Alexander Grishin, Alice K. Henning, Stacie M. Jones, Edwin H. Kim, Donald Y.M. Leung, Madhan Masilamani, Amy M. Scurlock, Scott H. Sicherer, Robert A. Wood, Hugh A. Sampson

    Riassunto Riassunto Mappa Mappa  
  • ·Efficacy and safety of baked milk oral immunotherapy in children with severe milk allergy: A randomized, double-blind, placebo-controlled phase 2 trial

    Pagina :1383

    Jennifer Dantzer, Joan Dunlop, Kevin J. Psoter, Corinne Keet, Robert Wood

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• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells

    Pagina :1392

    Yuzhi Yin, Yun Bai, Ana Olivera, Dean D. Metcalfe

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• Biologics and immunotherapy

  • ·Pustular psoriasis: Molecular pathways and effects of spesolimab in generalized pustular psoriasis

    Pagina :1402-1412

    Patrick Baum, Sudha Visvanathan, Sandra Garcet, Janine Roy, Ramona Schmid, Sebastian Bossert, Benjamin Lang, Hervé Bachelez, Robert Bissonnette, Christian Thoma, James G. Krueger

    Riassunto Riassunto Mappa Mappa   

• Mechanisms of allergy/immunology

  • ·The STE20 kinase TAOK3 controls the development of house dust mite–induced asthma in mice

    Pagina :1413

    Bastiaan Maes, Ursula Smole, Matthias Vanderkerken, Kim Deswarte, Justine Van Moorleghem, Karl Vergote, Manon Vanheerswynghels, Caroline De Wolf, Sofie De Prijck, Nincy Debeuf, Benjamin Pavie, Wendy Toussaint, Sophie Janssens, Savvas Savvides, Bart N. Lambrecht, Hamida Hammad

    Riassunto Riassunto Mappa Mappa  

• Translational and clinical immunology

  • ·Recommendations for uniform definitions used in newborn screening for severe combined immunodeficiency

    Pagina :1428-1436

    Maartje Blom, Rolf H. Zetterström, Asbjørg Stray-Pedersen, Kimberly Gilmour, Andrew R. Gennery, Jennifer M. Puck, Mirjam van der Burg

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• Environmental and occupational disease

  • ·Development and validation of the Exercise-Induced Laryngeal Obstruction Dyspnea Index (EILODI)

    Pagina :1437-1444

    James Tod Olin, Monica Shaffer, Emily Nauman, Catherine S. Durso, Elizabeth M. Fan, Herman Staudenmayer, Kent L. Christopher, Jackie Gartner-Schmidt

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  • ·ORMDL3 regulates cigarette smoke–induced endoplasmic reticulum stress in airway smooth muscle cells

    Pagina :1445

    Rui Chen, Charalambos Michaeloudes, Yingmin Liang, Pankaj K. Bhavsar, Kian Fan Chung, Mary S.M. Ip, Judith C.W. Mak

    Riassunto Riassunto Mappa Mappa  

• Brief reports

  • ·IgE cross-linking induces activation of human and mouse mast cell progenitors

    Pagina :1458-1463

    Erika Méndez-Enríquez, Maya Salomonsson, Jens Eriksson, Christer Janson, Andrei Malinovschi, Mikael E. Sellin, Jenny Hallgren

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  • ·Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK

    Pagina :1464

    Veronika Kanderova, Tamara Svobodova, Simon Borna, Martina Fejtkova, Vendula Martinu, Jana Paderova, Michael Svaton, Jarmila Kralova, Eva Fronkova, Adam Klocperk, Stepanka Pruhova, Min Ae Lee-Kirsch, Ludmila Hornofova, Miroslav Koblizek, Petr Novak, Olga Zimmermannova, Zuzana Parackova, Anna Sediva, Tomas Kalina, Ales Janda, Jana Kayserova, Marcela Dvorakova, Milan Macek, Petr Pohunek, Petr Sedlacek, Ashleigh Poh, Matthias Ernst, Tomas Brdicka, Ondrej Hrusak, Jan Lebl

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  • ·IL-33 signaling in sensory neurons promotes dry skin itch

    Pagina :1473

    Anna M. Trier, Madison R. Mack, Avery Fredman, Masato Tamari, Aaron M. Ver Heul, Yonghui Zhao, Changxiong J. Guo, Oshri Avraham, Zachary K. Ford, Landon K. Oetjen, Jing Feng, Carina Dehner, Dean Coble, Asima Badic, Satoru Joshita, Masato Kubo, Robert W. Gereau, Jennifer Alexander-Brett, Valeria Cavalli, Steve Davidson, Hongzhen Hu, Qin Liu, Brian S. Kim

    Riassunto Riassunto Mappa Mappa  
  • ·Association of mold levels in urban children’s homes with difficult-to-control asthma

    Pagina :1481-1485

    Stephen Vesper, Larry Wymer, John Kroner, Jacqueline A. Pongracic, Edward M. Zoratti, Frédéric F. Little, Robert A. Wood, Carolyn M. Kercsmar, Rebecca S. Gruchalla, Michelle A. Gill, Meyer Kattan, Stephen J. Teach, Shilpa Patel, Christine C. Johnson, Leonard B. Bacharier, James E. Gern, Daniel J. Jackson, Steven M. Sigelman, Alkis Togias, Andrew H. Liu, William W. Busse, Gurjit K. Khurana Hershey

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• Corrigendum

  • ·Corrigendum

    Pagina :1486-1489