Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :A5

    
• • ·Table of Contents

    Pagina :A7

    
• • ·Editorial Board

    Pagina :A38

    

• Reader services

  • ·Information for Readers

    Pagina :A39

    
  • ·News & Notes

    Pagina :A40

    Mappa Mappa  
  • ·CME Calendar-AAAAI

    Pagina :A43

    

• Reviews and feature articles

  • ·Diverse immune mechanisms of allergen immunotherapy for allergic rhinitis with and without asthma

    Pagina :791-801

    Mohamed H. Shamji, Hanisah Sharif, Janice A. Layhadi, Rongfei Zhu, Uday Kishore, Harald Renz

    Riassunto Riassunto Mappa Mappa  
  • ·Allergen immunotherapy for long-term tolerance and prevention

    Pagina :802-811

    Martin Penagos, Stephen R. Durham

    Riassunto Riassunto Mappa Mappa  
  • ·A regulator’s view on AIT clinical trials in the United States and Europe: Why successful studies fail to support licensure

    Pagina :812-818

    Andreas Bonertz, Anubha Tripathi, Julia Zimmer, Christina Reeb, Susanne Kaul, Jennifer Bridgewater, Ronald L. Rabin, Jay E. Slater, Stefan Vieths

    Riassunto Riassunto Mappa Mappa  
  • ·Pathogenic insights from genetic causes of autoinflammatory inflammasomopathies and interferonopathies

    Pagina :819-832

    Bin Lin, Raphaela Goldbach-Mansky

    Riassunto Riassunto Mappa Mappa  
  • ·Which patients with asthma are most likely to benefit from allergen immunotherapy?

    Pagina :833-843

    Frédéric de Blay, Alina Gherasim, Tomas B. Casale, Virginie Doyen, David Bernstein

    Riassunto Riassunto Mappa Mappa  
  • ·Impressions and aspirations from the FDA GREAT VI Workshop on Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis and Perspectives for Progress in the Field

    Pagina :844-853

    Marc E. Rothenberg, Shawna K.B. Hottinger, Nirmala Gonsalves, Glenn T. Furuta, Margaret H. Collins, Nicholas J. Talley, Kathryn Peterson, Calies Menard-Katcher, Macie Smith, Ikuo Hirano, Robert M. Genta, Mirna Chehade, Sandeep K. Gupta, Jonathan M. Spergel, Seema S. Aceves, Evan S. Dellon

    Riassunto Riassunto Mappa Mappa
  • ·Advances in chronic rhinosinusitis in 2020 and 2021

    Pagina :854-866

    Zhaofeng Xu, Yanran Huang, Tim Delemarre, Carlo Cavaliere, Nan Zhang, Claus Bachert

    Riassunto Riassunto Mappa Mappa  
  • ·The year in food allergy

    Pagina :867-873

    Corinne A. Keet, M. Cecilia Berin

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors’ Choice

    Pagina :874-878

    Mappa Mappa  

• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :879-880

    Marc E. Rothenberg, Jean Bousquet

    Mappa Mappa  

• Paradigms and perspectives

  • ·Real-world evidence: Methods for assessing long-term health and effectiveness of allergy immunotherapy

    Pagina :881-883

    Benedikt Fritzsching, Marco Contoli, Celeste Porsbjerg, Sarah Buchs, Julie Rask Larsen, Nick Freemantle

    Mappa Mappa  
  • ·Managing risk of anaphylaxis in patients receiving allergen immunotherapy: Assessing benefit versus risk

    Pagina :884-886

    David I. Bernstein, Tolly G. Epstein

    Mappa Mappa  

• Editorials

  • ·2021: The year in review

    Pagina :887-889

    Zuhair K. Ballas

    
  • ·Toward explaining fixed airflow obstruction in asthma

    Pagina :890-892

    Sandra Rutting, Katrina O. Tonga, Gregory G. King

     
  • ·Bacterial lysates to inhibit allergic airway disease: Are they up to the challenge?

    Pagina :893-894

    Christian Taube

     
  • ·Biologics for chronic rhinosinusitis with nasal polyps (CRSwNP)

    Pagina :895-897

    Glenis K. Scadding, Guy W. Scadding

    
  • ·Role of nasal microbiota and host response in infants with respiratory syncytial virus infection: Causal questions about respiratory outcomes

    Pagina :898-900

    Kohei Hasegawa, Carlos A. Camargo, Jonathan M. Mansbach

    
  • ·Recombinant allergens need a reality check

    Pagina :901-903

    Rob C. Aalberse

     
  • ·In vitro models of human mast cells: How to get more and better with induced pluripotent stem cells?

    Pagina :904-906

    Laurent L'homme, David Dombrowicz

    

• COVID-19

  • ·Immunogenicity and tolerability of COVID-19 messenger RNA vaccines in primary immunodeficiency patients with functional B-cell defects

    Pagina :907

    Michele N. Pham, Kanagavel Murugesan, Niaz Banaei, Benjamin A. Pinsky, Monica Tang, Elisabeth Hoyte, David B. Lewis, Yael Gernez

    Riassunto Riassunto Mappa Mappa  
  • ·Upregulation of type 1 conventional dendritic cells implicates antigen cross-presentation in multisystem inflammatory syndrome

    Pagina :912-922

    Janice J. Huang, Samantha B. Gaines, Mateo L. Amezcua, Tamar R. Lubell, Peter S. Dayan, Marissa Dale, Alexis D. Boneparth, Mark D. Hicar, Robert Winchester, Mark Gorelik

    Riassunto Riassunto Mappa Mappa   
  • ·The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression

    Pagina :923

    Vadim Pivniouk, Oksana Pivniouk, Avery DeVries, Jennifer L. Uhrlaub, Ashley Michael, Denis Pivniouk, Sydney R. VanLinden, Michelle Y. Conway, Seongmin Hahn, Sean P. Malone, Peace Ezeh, Jared M. Churko, Dayna Anderson, Monica Kraft, Janko Nikolich-Zugich, Donata Vercelli

    Riassunto Riassunto Mappa Mappa  

• Asthma and lower airway disease

  • ·Parenchymal destruction in asthma: Fixed airflow obstruction and lung function trajectory

    Pagina :934

    Kaoruko Shimizu, Naoya Tanabe, Akira Oguma, Hirokazu Kimura, Masaru Suzuki, Isao Yokota, Hironi Makita, Susumu Sato, Toyohiro Hirai, Masaharu Nishimura, Satoshi Konno, Hi-CARAT Investigators

    Riassunto Riassunto Mappa Mappa  
  • ·Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis

    Pagina :943-956

    Vadim Pivniouk, Joao A. Gimenes-Junior, Peace Ezeh, Ashley Michael, Oksana Pivniouk, Seongmin Hahn, Sydney R. VanLinden, Sean P. Malone, Amir Abidov, Dayna Anderson, Justyna Gozdz, Avery DeVries, Fernando D. Martinez, Christian Pasquali, Donata Vercelli

    Riassunto Riassunto Mappa Mappa   

• Rhinitis, sinusitis, and ocular allergy

  • ·Long-term efficacy and safety of omalizumab for nasal polyposis in an open-label extension study

    Pagina :957

    Philippe Gevaert, Rebecca Saenz, Jonathan Corren, Joseph K. Han, Joaquim Mullol, Stella E. Lee, Randall A. Ow, Rui Zhao, Monet Howard, Kit Wong, Lutaf Islam, Monica Ligueros-Saylan, Theodore A. Omachi, Claus Bachert

    Riassunto Riassunto Mappa Mappa  
  • ·Upper respiratory tract bacterial-immune interactions during respiratory syncytial virus infection in infancy

    Pagina :966-976

    Christian Rosas-Salazar, Zheng-Zheng Tang, Meghan H. Shilts, Kedir N. Turi, Qilin Hong, Derek A. Wiggins, Christian E. Lynch, Tebeb Gebretsadik, James D. Chappell, R. Stokes Peebles, Larry J. Anderson, Suman R. Das, Tina V. Hartert

    Riassunto Riassunto Mappa Mappa   

• Atopic dermatitis and inflammatory skin disease

  • ·Upadacitinib plus topical corticosteroids in atopic dermatitis: Week 52 AD Up study results

    Pagina :977

    Jonathan I. Silverberg, Marjolein de Bruin-Weller, Thomas Bieber, Weily Soong, Kenji Kabashima, Antonio Costanzo, David Rosmarin, Charles Lynde, John Liu, Amy Gamelli, Jiewei Zeng, Barry Ladizinski, Alvina D. Chu, Kristian Reich

    Riassunto Riassunto Mappa Mappa  

• Food allergy and gastrointestinal disease

  • ·A genome-wide association meta-analysis identifies new eosinophilic esophagitis loci

    Pagina :988-998

    Xiao Chang, Michael March, Frank Mentch, Kenny Nguyen, Joseph Glessner, Huiqi Qu, Yichuan Liu, Glen Furuta, Seema Aceves, Nirmala Gonsalves, Kari Nadeau, Antonella Cianferoni, Jonathan Spergel, Patrick Sleiman, Hakon Hakonarson

    Riassunto Riassunto Mappa Mappa   

• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Anaphylaxis knowledge gaps and future research priorities: A consensus report

    Pagina :999-1009

    Timothy E. Dribin, David Schnadower, Julie Wang, Carlos A. Camargo, Kenneth A. Michelson, Marcus Shaker, Susan A. Rudders, David Vyles, David B.K. Golden, Jonathan M. Spergel, Ronna L. Campbell, Mark I. Neuman, Peter S. Capucilli, Michael Pistiner, Mariana Castells, Juhee Lee, David C. Brousseau, Lynda C. Schneider, Amal H. Assa’ad, Kimberly A. Risma, Rakesh D. Mistry, Dianne E. Campbell, Margitta Worm, Paul J. Turner, John K. Witry, Yin Zhang, Brad Sobolewski, Hugh A. Sampson

    Riassunto Riassunto Mappa Mappa   
  • ·Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis

    Pagina :1010

    Allyson Mateja, Qinlu Wang, Jack Chovanec, Jiwon Kim, Kenneth J. Wilson, Lawrence B. Schwartz, Sarah C. Glover, Melody C. Carter, Dean D. Metcalfe, Erica Brittain, Jonathan J. Lyons

    Riassunto Riassunto Mappa Mappa  

• Biologics and immunotherapy

  • ·A novel functional mast cell assay for the detection of allergies

    Pagina :1018

    Noemi Zbären, Daniel Brigger, Daniel Bachmann, Arthur Helbling, Lukas Jörg, Michael P. Horn, Johannes M. Schmid, Hans Jürgen Hoffmann, Jean-Pierre Kinet, Thomas Kaufmann, Alexander Eggel

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy/immunology

  • ·IgE recognition of the house dust mite allergen Der p 37 is associated with asthma

    Pagina :1031-1043

    Huey-Jy Huang, Yvonne Resch-Marat, Anne Casset, Margit Weghofer, Petra Zieglmayer, René Zieglmayer, Patrick Lemell, Friedrich Horak, Kuan-Wei Chen, Ekaterina Potapova, Paolo M. Matricardi, Gabrielle Pauli, Monika Grote, Rudolf Valenta, Susanne Vrtala

    Riassunto Riassunto Mappa Mappa   
  • ·TLR3-driven IFN-β antagonizes STAT5-activating cytokines and suppresses innate type 2 response in the lung

    Pagina :1044

    Rinna Tei, Koji Iijima, Koji Matsumoto, Takao Kobayashi, Jyoti Lama, Elizabeth A. Jacobsen, Hirohito Kita

    Riassunto Riassunto Mappa Mappa  
  • ·A novel approach for studying mast cell–driven disorders: Mast cells derived from induced pluripotent stem cells

    Pagina :1060

    Yanyan Luo, Valeria Fernandez Vallone, Jiajun He, Stefan Frischbutter, Pavel Kolkhir, Sherezade Moñino-Romero, Harald Stachelscheid, Viktoria Streu-Haddad, Marcus Maurer, Frank Siebenhaar, Jörg Scheffel

    Riassunto Riassunto Mappa Mappa  
  • ·Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation

    Pagina :1069-1084

    Minghui He, Mezida B. Saeed, Julien Record, Marton Keszei, Lia Gonçalves Pinho, Larissa Vasconcelos-Fontes, Roberta D’Aulerio, Rhaissa Vieira, Mariana M.S. Oliveira, Chiara Geyer, Lena Bohaumilitzky, Meike Thiemann, Ekaterina Deordieva, Lieselot Buedts, Joao Pedro Matias Lopes, Dmitry Pershin, Lennart Hammarström, Yu Xia, Xiaodong Zhao, Charlotte Cunningham-Rundles, Adrian J. Thrasher, Siobhan O. Burns, Vinicius Cotta-de-Almeida, Chaohong Liu, Anna Shcherbina, Peter Vandenberghe, Lisa S. Westerberg

    Riassunto Riassunto Mappa Mappa   
  • ·Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV

    Pagina :1085-1096

    Eriko Komiya, Mitsutoshi Tominaga, Ryo Hatano, Yuji Kamikubo, Sumika Toyama, Hakushun Sakairi, Kotaro Honda, Takumi Itoh, Yayoi Kamata, Munehiro Tsurumachi, Ryoma Kishi, Kei Ohnuma, Takashi Sakurai, Chikao Morimoto, Kenji Takamori

    Riassunto Riassunto Mappa Mappa   

• Translational and clinical immunology

  • ·Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders

    Pagina :1097

    Rebecca A. Marsh, Kyle Hebert, Soyoung Kim, Christopher C. Dvorak, Victor M. Aquino, K. Scott Baker, Deepak Chellapandian, Blachy Dávila Saldaña, Christine N. Duncan, Michael J. Eckrich, George E. Georges, Timothy S. Olson, Michael A. Pulsipher, Shalini Shenoy, Elizabeth Stenger, Mark Vander Lugt, Lolie C. Yu, Andrew R. Gennery, Mary Eapen

    Riassunto Riassunto Mappa Mappa  

• Brief reports

  • ·Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis

    Pagina :1105

    Eeva Sliz, Laura Huilaja, Anu Pasanen, Triin Laisk, Ene Reimann, Reedik Mägi, FinnGen, Estonian Biobank Research Team, Katariina Hannula-Jouppi, Sirkku Peltonen, Teea Salmi, Leena Koulu, Kaisa Tasanen, Johannes Kettunen

    Riassunto Riassunto Mappa Mappa  
  • ·Poor T-cell receptor β repertoire diversity early posttransplant for severe combined immunodeficiency predicts failure of immune reconstitution

    Pagina :1113-1119

    Ottavia M. Delmonte, Riccardo Castagnoli, Jason Yu, Christopher C. Dvorak, Morton J. Cowan, Blachy J. Dávila Saldaña, Suk See De Ravin, Ewelina Mamcarz, Catherine K. Chang, Stephen R. Daley, Linda M. Griffith, Luigi D. Notarangelo, Jennifer M. Puck

    Riassunto Riassunto Mappa Mappa  
  • ·Hematopoietic stem cell transplantation in a patient with proteasome-associated autoinflammatory syndrome (PRAAS)

    Pagina :1120

    Dorit Verhoeven, Dieneke Schonenberg-Meinema, Frédéric Ebstein, Jonas J. Papendorf, Paul A. Baars, Ester M.M. van Leeuwen, Machiel H. Jansen, Arjan C. Lankester, Mirjam van der Burg, Sandrine Florquin, Saskia M. Maas, Silvana van Koningsbruggen, Elke Krüger, J. Merlijn van den Berg, Taco W. Kuijpers

    Riassunto Riassunto Mappa Mappa  

• Correspondence

  • ·Life-threatening anaphylaxis to peanut — impossible to predict?

    Pagina :1128-1129

    Paul J. Turner, Adnan Custovic

     
  • ·Reply

    Pagina :1129-1131

    Alexandra F. Santos, Ethan Evans, Colin O'Rourke, Henry T. Bahnson, Gideon Lack

     
  • ·Epithelial repair in asthma: Defect or exaggerated?

    Pagina :1131-1132

    Carl Persson

    
  • ·Reply

    Pagina :1132-1133

    Mingzhu Jin, Simon Watkins, Yolanda Larriba, Callen Wallace, Claudette St. Croix, Xiuxia Zhou, Jinming Zhao, Shyamal Peddada, Sally E. Wenzel

    

• Corrigenda

  • ·Corrigendum

    Pagina :1134-1135

     
  • ·Corrigendum

    Pagina :1136