Sommario

• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

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• • ·Table of Contents

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• • ·Editorial Board

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• Reader services

  • ·Information for Readers

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  • ·News & Notes

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  • ·Continuing Medical Education Calendar

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• Reviews and feature articles

  • ·Safety of anti-TNF agents in pregnancy

    Pagina :661-667

    Kara M. De Felice, Sunanda Kane

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  • ·Safety of anti-TNF agents in pregnancy

    Pagina :668

    
  • ·The maternal gut microbiome during pregnancy and offspring allergy and asthma

    Pagina :669-678

    Yuan Gao, Ralph Nanan, Laurence Macia, Jian Tan, Luba Sominsky, Thomas P. Quinn, Martin O’Hely, Anne-Louise Ponsonby, Mimi L.K. Tang, Fiona Collier, Deborah H. Strickland, Poshmaal Dhar, Susanne Brix, Simon Phipps, Peter D. Sly, Sarath Ranganathan, Jakob Stokholm, Karsten Kristiansen, Lawrence E.K. Gray, Peter Vuillermin

    Riassunto Riassunto Mappa Mappa  
  • ·Allergen shedding in human milk: Could it be key for immune system education and allergy prevention?

    Pagina :679-688

    Patricia Macchiaverni, Akila Rekima, Lieke van den Elsen, Harald Renz, Valerie Verhasselt

    Riassunto Riassunto Mappa Mappa  
  • ·The airway as a route of sensitization to peanut: An update to the dual allergen exposure hypothesis

    Pagina :689-693

    Michael D. Kulis, Johanna M. Smeekens, Robert M. Immormino, Timothy P. Moran

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• The Editors' choice

  • ·The Editors’ Choice

    Pagina :694-699

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :700-701

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·IgE autoantibodies: An innate connection to adaptive immunity

    Pagina :702-705

    Xin Huang, Mikael C.I. Karlsson

     
  • ·Diet and asthma: Is the sum more important than the parts?

    Pagina :706-707

    Jessica Reyes-Angel, Yueh-Ying Han, Augusto A. Litonjua, Juan C. Celedón

     

• Editorials

  • ·Basophil: The cell that itches

    Pagina :708-709

    Mrinmoy Das, Juan-Manuel Leyva-Castillo, Raif S. Geha

     
  • ·Airway remodeling: Shifting the trigger point for exacerbations in asthma

    Pagina :710-712

    Tilo Winkler, Urs Frey

     
  • ·Beyond obesity: The complex relationship between early growth trajectories and later lung function

    Pagina :713-715

    Katherine A. Krol, Augusto A. Litonjua

     
  • ·Prenatal exposure to particulate matter air pollution: A preventable risk for childhood asthma

    Pagina :716-718

    David B. Peden

     
  • ·Emerging targeted therapeutics underscore immunologic heterogeneity of asthma

    Pagina :719-721

    Masato Tamari, Anna M. Trier, Brian S. Kim

     
  • ·New insights into human atopic dermatitis provided by mouse models

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    Kenji Matsumoto, Hideaki Morita, Susumu Nakae

    
  • ·Sensory neurons drive adaptive immunity in contact hypersensitivity

    Pagina :725-727

    Knut Schäkel

     

• COVID-19

  • ·Maternal COVID-19, vaccination safety in pregnancy, and evidence of protective immunity

    Pagina :728-731

    Amelie Pham, David M. Aronoff, Jennifer L. Thompson

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  • ·Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C)

    Pagina :732

    Janet Chou, Craig D. Platt, Saddiq Habiballah, Alan A. Nguyen, Megan Elkins, Sabrina Weeks, Zachary Peters, Megan Day-Lewis, Tanya Novak, Myriam Armant, Lucinda Williams, Shira Rockowitz, Piotr Sliz, David A. Williams, Adrienne G. Randolph, Raif S. Geha, Taking on COVID-19 Together Study Investigators, Abduarahman Almutairi, Faris Jaber, Tina Banzon, Jordan Roberts, Olha Halyabar, Mindy Lo, Stacy Kahn, Lauren A. Henderson, Pui Y. Lee, Mary Beth Son, Leah Cheng

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  • ·Immunogenicity of Pfizer-BioNTech COVID-19 vaccine in patients with inborn errors of immunity

    Pagina :739-749

    David Hagin, Tal Freund, Michal Navon, Tami Halperin, Dikla Adir, Rotem Marom, Inbar Levi, Shira Benor, Yifat Alcalay, Natalia T. Freund

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  • ·Subepidermal blistering eruptions, including bullous pemphigoid, following COVID-19 vaccination

    Pagina :750-751

    Mary M. Tomayko, William Damsky, Ramie Fathy, Devon E. McMahon, Noel Turner, Monica N. Valentin, Tena Rallis, Ohara Aivaz, Lindy P. Fox, Esther E. Freeman

    

• Asthma and lower airway disease

  • ·Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3

    Pagina :752-762

    James G. Krings, Charles W. Goss, Daphne Lew, Maanasi Samant, Mary Clare McGregor, Jonathan Boomer, Leonard B. Bacharier, Ajay Sheshadri, Chase Hall, Joshua Brownell, Ken B. Schechtman, Samuel Peterson, Stephen McEleney, David T. Mauger, John V. Fahy, Sean B. Fain, Loren C. Denlinger, Elliot Israel, George Washko, Eric Hoffman, Sally E. Wenzel, Mario Castro, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program Investigators

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  • ·Infant body mass index trajectories and asthma and lung function

    Pagina :763-770

    Gulshan Bano Ali, Dinh Son Bui, Caroline Jane Lodge, Nilakshi T. Waidyatillake, Jennifer L. Perret, Cong Sun, Eugene Haydn Walters, Michael John Abramson, Adrian J. Lowe, Shyamali Chandrika Dharmage

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  • ·Early-life exposure to submicron particulate air pollution in relation to asthma development in Chinese preschool children

    Pagina :771

    Yunquan Zhang, Jing Wei, Yuqin Shi, Chao Quan, Hung Chak Ho, Yimeng Song, Ling Zhang

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  • ·Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial

    Pagina :783-789

    Irene E. Braithwaite, Fang Cai, Jennifer A. Tom, Joshua M. Galanter, Ryan P. Owen, Rui Zhu, Mathew Williams, Anna G. McGregor, Avi Eliahu, Matthew R. Durk, Hart S. Dengler, Mark Zak, Jane R. Kenny, Maria E. Wilson, Richard Beasley, Hubert Chen

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  • ·Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial

    Pagina :790-798

    Steven G. Kelsen, Ioana O. Agache, Weily Soong, Elliot Israel, Geoffrey L. Chupp, Dorothy S. Cheung, Wiebke Theess, Xiaoying Yang, Tracy L. Staton, David F. Choy, Alice Fong, Ajit Dash, Michael Dolton, Rajita Pappu, Christopher E. Brightling

    Riassunto Riassunto Mappa Mappa   

• Atopic dermatitis and inflammatory skin disease

  • ·Basophils promote barrier dysfunction and resolution in the atopic skin

    Pagina :799

    Christophe Pellefigues, Karmella Naidoo, Palak Mehta, Alfonso J. Schmidt, Ferdinand Jagot, Elsa Roussel, Alissa Cait, Bibek Yumnam, Sally Chappell, Kimberley Meijlink, Mali Camberis, Jean X. Jiang, Gavin Painter, Kara Filbey, Özge Uluçkan, Olivier Gasser, Graham Le Gros

    Riassunto Riassunto Mappa Mappa  

• Food allergy and gastrointestinal disease

  • ·Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia

    Pagina :813

    Liza Konnikova, Tanya O. Robinson, Anna H. Owings, James F. Shirley, Elisabeth Davis, Ying Tang, Sarah Wall, Jian Li, Mohammad H. Hasan, Raad Z. Gharaibeh, Lybil B. Mendoza Alvarez, Lisa K. Ryan, Andria Doty, Jack F. Chovanec, Michael P. O’Connell, Dianne E. Grunes, William P. Daley, Emeran Mayer, Lin Chang, Julia Liu, Scott B. Snapper, Joshua D. Milner, Sarah C. Glover, Jonathan J. Lyons

    Riassunto Riassunto Mappa Mappa  

• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Efficacy of medical treatments for vernal keratoconjunctivitis: A systematic review and meta-analysis

    Pagina :822-834

    Inès Roumeau, Adrien Coutu, Valentin Navel, Bruno Pereira, Julien S. Baker, Frédéric Chiambaretta, Dominique Bremond-Gignac, Frédéric Dutheil

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• Mechanisms of allergy/immunology

  • ·Evolution of epitope-specific IgE and IgG₄ antibodies in children enrolled in the LEAP trial

    Pagina :835-842

    Mayte Suarez-Farinas, Maria Suprun, Henry T. Bahnson, Rohit Raghunathan, Robert Getts, George duToit, Gideon Lack, Hugh A. Sampson

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  • ·Fetomaternal immune cross talk modifies T-cell priming through sustained changes to DC function

    Pagina :843

    Matthew Lacorcia, Sonakshi Bhattacharjee, Kristina Laubhahn, Fahd Alhamdan, Marija Ram, Andreas Muschaweckh, Daniel P. Potaczek, Anna Kosinska, Holger Garn, Ulrike Protzer, Harald Renz, Clarissa Prazeres da Costa

    Riassunto Riassunto Mappa Mappa  
  • ·Pituitary adenylate cyclase-activating polypeptide promotes cutaneous dendritic cell functions in contact hypersensitivity

    Pagina :858-866

    Yasuo Yamamoto, Atsushi Otsuka, Yoshihiro Ishida, Lai San Wong, Judith A. Seidel, Yumi Nonomura, Chisa Nakashima, Saeko Nakajima, Akihiko Kitoh, Takashi Nomura, Teruki Dainichi, Tetsuya Honda, Wataru Amano, Noriko Konishi, Mikio Hayashi, Mutsuyoshi Matsushita, Kenji Kabashima

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  • ·Optimal human pathogenic T_H2 cell effector function requires local epithelial cytokine signaling

    Pagina :867

    Justine Calise, Nahir Garabatos, Veronique Bajzik, Mary Farrington, David Robinson, David Jeong, Marco Londei, Erik Wambre

    Riassunto Riassunto Mappa Mappa  

• Translational and clinical immunology

  • ·Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1

    Pagina :876-888

    Anders Ø. Petersen, Martta Jokinen, Damian R. Plichta, Gerhard Liebisch, Wolfram Gronwald, Katja Dettmer, Peter J. Oefner, Hera Vlamakis, Daniel C. Chung, Annamari Ranki, Ramnik J. Xavier

    Riassunto Riassunto Mappa Mappa   

• Brief reports

  • ·Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis

    Pagina :889-894

    Theo Gülen, Andrea Teufelberger, Maria Ekoff, Christine Möller Westerberg, Katarina Lyberg, Sven-Erik Dahlén, Barbro Dahlén, Gunnar Nilsson

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  • ·Acute FPIES reactions are associated with an IL-17 inflammatory signature

    Pagina :895

    M. Cecilia Berin, Daniel Lozano-Ojalvo, Charuta Agashe, Mary Grace Baker, J. Andrew Bird, Anna Nowak-Wegrzyn

    Riassunto Riassunto Mappa Mappa  

• Correspondence

  • ·In vivo and in vitro testing with PEGylated nanoparticles

    Pagina :902

    John M. Kelso

    
  • ·Reply

    Pagina :902-903

    Griffith Perkins, Alexander Troelnikov, Pravin Hissaria

     
  • ·Maternal IgE is transferred to fetuses with IgG and minimally sensitizes fetal/neonatal skin mast cells

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    Yuki Honda Keith, Kenji Kabashima

     
  • ·Reply

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    Daniel F. Dwyer, Joshua A. Boyce

    

• Corrigenda

  • ·Corrigenda

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  • ·Corrigenda

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  • ·Corrigenda

    Pagina :906-907

     
  • ·Corrigenda

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• The Last Page

  • ·SARS-CoV-2–infected primary human airway epithelia illustrate mucus hypersecretion

    Pagina :909

    Wilfried Posch, Cornelia Lass-Flörl, Doris Wilflingseder