Sommario

• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

    Pagina :5A

    
• • ·Table of Contents

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• • ·Editorial Board

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• Reader services

  • ·Information for Readers

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  • ·News & Notes

    Pagina :40A

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  • ·CME Activities Calendar

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• Reviews and feature articles

  • ·Lessons learned from birth cohort studies conducted in diverse environments

    Pagina :379-386

    Daniel J. Jackson, James E. Gern, Robert F. Lemanske

    Riassunto Riassunto Mappa Mappa  
  • ·Lessons learned from birth cohort studies conducted in diverse environments

    Pagina :387

    
  • ·Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

    Pagina :388-399

    Josep M. Anto, Jean Bousquet, Mubeccel Akdis, Charles Auffray, Thomas Keil, Isabelle Momas, Dirkje S. Postma, Rudolf Valenta, Magnus Wickman, Anne Cambon-Thomsen, Tari Haahtela, Bart N. Lambrecht, Karin C. Lodrup Carlsen, Gerard H. Koppelman, Jordi Sunyer, Torsten Zuberbier, Isabelle Annesi-Maesano, Albert Arno, Carsten Bindslev-Jensen, Giuseppe De Carlo, Francesco Forastiere, Joachim Heinrich, Marek L. Kowalski, Dieter Maier, Erik Melén, Henriette A. Smit, Marie Standl, John Wright, Anna Asarnoj, Marta Benet, Natalia Ballardini, Judith Garcia-Aymerich, Ulrike Gehring, Stefano Guerra, Cynthia Hohmann, Inger Kull, Christian Lupinek, Mariona Pinart, Ingebjorg Skrindo, Marit Westman, Delphine Smagghe, Cezmi Akdis, Niklas Andersson, Claus Bachert, Stephane Ballereau, Ferran Ballester, Xavier Basagana, Anna Bedbrook, Anna Bergstrom, Andrea von Berg, Bert Brunekreef, Emilie Burte, Kai-Hakon Carlsen, Leda Chatzi, Jonathan M. Coquet, Mirela Curin, Pascal Demoly, Esben Eller, Maria Pia Fantini, Leena von Hertzen, Vergard Hovland, Benedicte Jacquemin, Jocelyne Just, Theresa Keller, Renata Kiss, Manolis Kogevinas, Sibylle Koletzko, Susanne Lau, Irina Lehmann, Nicolas Lemonnier, Mika Mäkelä, Jordi Mestres, Peter Mowinckel, Rachel Nadif, Martijn C. Nawijn, Johan Pellet, Isabelle Pin, Daniela Porta, Fanny Rancière, Emmanuelle Rial-Sebbag, Yvan Saeys, Martijn J. Schuijs, Valerie Siroux, Christina G. Tischer, Mathies Torrent, Raphaelle Varraso, Kalus Wenzel, Cheng-Jian Xu

    Riassunto Riassunto Mappa Mappa  
  • ·Disaggregating asthma: Big investigation versus big data

    Pagina :400-407

    Danielle Belgrave, John Henderson, Angela Simpson, Iain Buchan, Christopher Bishop, Adnan Custovic

    Riassunto Riassunto Mappa Mappa  
  • ·The Finnish experience to save asthma costs by improving care in 1987-2013

    Pagina :408

    Tari Haahtela, Fredrik Herse, Jussi Karjalainen, Timo Klaukka, Miika Linna, Riikka-Leena Leskelä, Olof Selroos, Eeva Reissell

    Riassunto Riassunto Mappa Mappa  
  • ·Multigenerational cohorts in patients with asthma and allergy

    Pagina :415-421

    S. Hasan Arshad, Wilfried Karmaus, Hongmei Zhang, John W. Holloway

    Riassunto Riassunto Mappa Mappa  
  • ·Half-life of IgE in serum and skin: Consequences for anti-IgE therapy in patients with allergic disease

    Pagina :422

    Monica G. Lawrence, Judith A. Woodfolk, Alexander J. Schuyler, Leland C. Stillman, Martin D. Chapman, Thomas A.E. Platts-Mills

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  • ·The false alarm hypothesis: Food allergy is associated with high dietary advanced glycation end-products and proglycating dietary sugars that mimic alarmins

    Pagina :429-437

    Peter K. Smith, Madhan Masilamani, Xiu-Min Li, Hugh A. Sampson

    Riassunto Riassunto Mappa Mappa  
  • ·Acute asthma, prognosis, and treatment

    Pagina :438-447

    Jennifer E. Fergeson, Shiven S. Patel, Richard F. Lockey

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  • ·Weighing the evidence: Bias and confounding in epidemiologic studies in allergy/immunology

    Pagina :448-450

    Elizabeth C. Matsui, Corinne A. Keet

    

• The Editors' choice

  • ·The Editors' Choice

    Pagina :451-452

    Cezmi A. Akdis, Zuhair K. Ballas, Associate Editors of the JACI

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :453-454

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Allergy and infant feeding guidelines in the context of resource-constrained settings

    Pagina :455-458

    Michael Levin, Ameena Goga, Tanya Doherty, Hoosen Coovadia, David Sanders, Robin J. Green, Sharon Kling

     

• Editorial

  • ·Vitamin D status through the first 10 years of life: A vital piece of the puzzle in asthma inception

    Pagina :459-461

    Augusto A. Litonjua, Scott T. Weiss

     

• Asthma and lower airway disease

  • ·IL-17A enhances IL-13 activity by enhancing IL-13–induced signal transducer and activator of transcription 6 activation

    Pagina :462

    Sara L. Hall, Theresa Baker, Stephane Lajoie, Phoebe K. Richgels, Yanfen Yang, Jaclyn W. McAlees, Adelaide van Lier, Marsha Wills-Karp, Umasundari Sivaprasad, Thomas H. Acciani, Timothy D. LeCras, Jocelyn Biagini Myers, Melinda Butsch Kovacic, Ian P. Lewkowich

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  • ·Vitamin D over the first decade and susceptibility to childhood allergy and asthma

    Pagina :472

    Elysia M. Hollams, Shu Mei Teo, Merci Kusel, Barbara J. Holt, Kathryn E. Holt, Michael Inouye, Nicholas H. De Klerk, Guicheng Zhang, Peter D. Sly, Prue H. Hart, Patrick G. Holt

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  • ·Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART)

    Pagina :482

    Joanne E. Sordillo, Yanjiao Zhou, Michael J. McGeachie, John Ziniti, Nancy Lange, Nancy Laranjo, Jessica R. Savage, Vincent Carey, George O'Connor, Megan Sandel, Robert Strunk, Leonard Bacharier, Robert Zeiger, Scott T. Weiss, George Weinstock, Diane R. Gold, Augusto A. Litonjua

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  • ·Staphylococcal serine protease–like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus

    Pagina :492

    Sebastian Stentzel, Andrea Teufelberger, Maria Nordengrün, Julia Kolata, Frank Schmidt, Koen van Crombruggen, Stephan Michalik, Jana Kumpfmüller, Sebastian Tischer, Thomas Schweder, Michael Hecker, Susanne Engelmann, Uwe Völker, Olga Krysko, Claus Bachert, Barbara M. Bröker

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  • ·Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence

    Pagina :501-507

    Frederick J. Rubner, Daniel J. Jackson, Michael D. Evans, Ronald E. Gangnon, Christopher J. Tisler, Tressa E. Pappas, James E. Gern, Robert F. Lemanske

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  • ·Staphylococcal enterotoxin A–activated regulatory T cells promote allergen-specific T_H2 response to intratracheal allergen inoculation

    Pagina :508

    Wei-ping Zeng, Margaret M. McFarland, Baohua Zhou, Silva Holtfreter, Susan Flesher, Ambrose Cheung, Avishek Mallick

    Riassunto Riassunto Mappa Mappa  
  • ·MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2

    Pagina :519-532

    Richard Y. Kim, Jay C. Horvat, James W. Pinkerton, Malcolm R. Starkey, Ama T. Essilfie, Jemma R. Mayall, Prema M. Nair, Nicole G. Hansbro, Bernadette Jones, Tatt Jhong Haw, Krishna P. Sunkara, Thi Hiep Nguyen, Andrew G. Jarnicki, Simon Keely, Joerg Mattes, Ian M. Adcock, Paul S. Foster, Philip M. Hansbro

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• Rhinitis, sinusitis, and upper airway disease

  • ·Genome-wide association study on the FEV₁/FVC ratio in never-smokers identifies HHIP and FAM13A

    Pagina :533-540

    Diana A. van der Plaat, Kim de Jong, Lies Lahousse, Alen Faiz, Judith M. Vonk, Cleo C. van Diemen, Ivana Nedeljkovic, Najaf Amin, Guy G. Brusselle, Albert Hofman, Corry-Anke Brandsma, Yohan Bossé, Don D. Sin, David C. Nickle, Cornelia M. van Duijn, Dirkje S. Postma, H. Marike Boezen

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  • ·Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life

    Pagina :541

    Daniela Posa, Serena Perna, Yvonne Resch, Christian Lupinek, Valentina Panetta, Stephanie Hofmaier, Alexander Rohrbach, Laura Hatzler, Linus Grabenhenrich, Olympia Tsilochristou, Kuan-Wei Chen, Carl-Peter Bauer, Ute Hoffman, Johannes Forster, Fred Zepp, Antje Schuster, Ulrich Wahn, Thomas Keil, Susanne Lau, Susanne Vrtala, Rudolf Valenta, Paolo Maria Matricardi

    Riassunto Riassunto Mappa Mappa  

• Atopic dermatitis and skin disease

  • ·MicroRNA-146a suppresses IL-17–mediated skin inflammation and is genetically associated with psoriasis

    Pagina :550-561

    Ankit Srivastava, Pernilla Nikamo, Warangkana Lohcharoenkal, Dongqing Li, Florian Meisgen, Ning Xu Landén, Mona Ståhle, Andor Pivarcsi, Enikö Sonkoly

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  • ·Major differences between human atopic dermatitis and murine models, as determined by using global transcriptomic profiling

    Pagina :562-571

    David A. Ewald, Shinji Noda, Margeaux Oliva, Thomas Litman, Saeko Nakajima, Xuan Li, Hui Xu, Christopher T. Workman, Peter Scheipers, Naila Svitacheva, Tord Labuda, James G. Krueger, Mayte Suárez-Fariñas, Kenji Kabashima, Emma Guttman-Yassky

    Riassunto Riassunto Mappa Mappa   

• Food, drug, insect sting allergy, and anaphylaxis

  • ·Humoral and cellular responses to casein in patients with food protein–induced enterocolitis to cow's milk

    Pagina :572-583

    Jean Christoph Caubet, Ramon Bencharitiwong, Andrew Ross, Hugh A. Sampson, M. Cecilia Berin, Anna Nowak-W?grzyn

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  • ·Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis

    Pagina :584

    Bianca Balbino, Riccardo Sibilano, Philipp Starkl, Thomas Marichal, Nicolas Gaudenzio, Hajime Karasuyama, Pierre Bruhns, Mindy Tsai, Laurent L. Reber, Stephen J. Galli

    Riassunto Riassunto Mappa Mappa  

• Immune deficiencies, infection, and systemic immune disorders

  • ·Clinical spectrum and features of activated phosphoinositide 3-kinase ? syndrome: A large patient cohort study

    Pagina :597

    Tanya I. Coulter, Anita Chandra, Chris M. Bacon, Judith Babar, James Curtis, Nick Screaton, John R. Goodlad, George Farmer, Cathal Laurence Steele, Timothy Ronan Leahy, Rainer Doffinger, Helen Baxendale, Jolanta Bernatoniene, J. David M. Edgar, Hilary J. Longhurst, Stephan Ehl, Carsten Speckmann, Bodo Grimbacher, Anna Sediva, Tomas Milota, Saul N. Faust, Anthony P. Williams, Grant Hayman, Zeynep Yesim Kucuk, Rosie Hague, Paul French, Richard Brooker, Peter Forsyth, Richard Herriot, Caterina Cancrini, Paolo Palma, Paola Ariganello, Niall Conlon, Conleth Feighery, Patrick J. Gavin, Alison Jones, Kohsuke Imai, Mohammad A.A. Ibrahim, Gašper Markelj, Mario Abinun, Frédéric Rieux-Laucat, Sylvain Latour, Isabelle Pellier, Alain Fischer, Fabien Touzot, Jean-Laurent Casanova, Anne Durandy, Siobhan O. Burns, Sinisa Savic, D.S. Kumararatne, Despina Moshous, Sven Kracker, Bart Vanhaesebroeck, Klaus Okkenhaug, Capucine Picard, Sergey Nejentsev, Alison M. Condliffe, Andrew James Cant

    Riassunto Riassunto Mappa Mappa  
  • ·Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells

    Pagina :607

    Hannah H. Chen, Norman Händel, Joanne Ngeow, James Muller, Michael Hühn, Huei-Ting Yang, Mario Heindl, Roos-Marijn Berbers, Ahmed N. Hegazy, Janina Kionke, Lamis Yehia, Ulrich Sack, Frank Bläser, Anne Rensing-Ehl, Julia Reifenberger, Julia Keith, Simon Travis, Andreas Merkenschlager, Wieland Kiess, Christian Wittekind, Lisa Walker, Stephan Ehl, Stefan Aretz, Michael L. Dustin, Charis Eng, Fiona Powrie, Holm H. Uhlig

    Riassunto Riassunto Mappa Mappa  
  • ·Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behçet's disease in Han Chinese

    Pagina :621-627

    Hongsong Yu, Minming Zheng, Lijun Zhang, Hua Li, Yunyun Zhu, Ling Cheng, Lin Li, Bolin Deng, Aize Kijlstra, Peizeng Yang

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  • ·Transplacental maternal engraftment and posttransplantation graft-versus-host disease in children with severe combined immunodeficiency

    Pagina :628

    Justin Wahlstrom, Kiran Patel, Erik Eckhert, Denice Kong, Biljana Horn, Morton J. Cowan, Christopher C. Dvorak

    Riassunto Riassunto Mappa Mappa  
  • ·Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency

    Pagina :634

    Chiara Bacchelli, Federico A. Moretti, Marlene Carmo, Stuart Adams, Horia C. Stanescu, Kerra Pearce, Manisha Madkaikar, Kimberly C. Gilmour, Adeline K. Nicholas, C. Geoffrey Woods, Robert Kleta, Phil L. Beales, Waseem Qasim, H. Bobby Gaspar

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy and clinical immunology

  • ·Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study

    Pagina :643

    Valérie Siroux, Christian Lupinek, Yvonne Resch, Mirela Curin, Jocelyne Just, Thomas Keil, Renata Kiss, Karin Lødrup Carlsen, Erik Melén, Rachel Nadif, Isabelle Pin, Ingebjørg Skrindo, Susanne Vrtala, Magnus Wickman, Josep Maria Anto, Rudolf Valenta, Jean Bousquet

    Riassunto Riassunto Mappa Mappa  
  • ·Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells

    Pagina :655

    Yashaswini Kannan, Yanda Li, Stephanie M. Coomes, Isobel S. Okoye, Victoria S. Pelly, Srividya Sriskantharajah, Eva Gückel, Lauren Webb, Stephanie Czieso, Nikolay Nikolov, Andrew S. MacDonald, Steven C. Ley, Mark S. Wilson

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  • ·Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects

    Pagina :667

    Karina Stein, Stephanie Brand, André Jenckel, Anna Sigmund, Zhijian James Chen, Carsten J. Kirschning, Marion Kauth, Holger Heine

    Riassunto Riassunto Mappa Mappa  

• Letters to the Editor

  • ·IgE-reactivity profiles to nonspecific lipid transfer proteins in a northwestern European country

    Pagina :679

    Margaretha A. Faber, Athina L. Van Gasse, Ine I. Decuyper, Astrid Uyttebroek, Vito Sabato, Margo M. Hagendorens, Chris H. Bridts, Luc S. De Clerck, Montserrat Fernandez-Rivas, Mariona Pascal, Araceli Diaz-Perales, Didier G. Ebo

     
  • ·Restrictive IL-10 induction by an innocuous parainfluenza virus vector ameliorates nasal allergy

    Pagina :682

    Keiichi Yamanaka, Takehisa Nakanishi, Kana Isono, Chisami Hasegawa, Hiroyasu Inada, Kento Mizutani, Yoshiaki Matsushima, Karin Okada, Tomotaka Mabuchi, Makoto Kondo, Akisa Yamagiwa, Masato Kakeda, Koji Habe, Tetsuya Nosaka, Esteban C. Gabazza, Hidetoshi Yamazaki, Hitoshi Mizutani, Mitsuo Kawano

     
  • ·Allergy-related disease in relation to early life exposures—the ALADDIN birth cohort

    Pagina :686-688

    Helena Marell Hesla, Fredrik Stenius, Hans Järnbert-Pettersson, Johan Alm

      
  • ·Specific IgE to Jug r 1 has no additional value compared with extract-based testing in diagnosing walnut allergy in adults

    Pagina :688

    Mark A. Blankestijn, W. Marty Blom, Henny G. Otten, Joe L. Baumert, Steve L. Taylor, Carla A.F.M. Bruijnzeel-Koomen, Geert F. Houben, André C. Knulst, Rob J.B. Klemans

     
  • ·Estimated disease incidence of RAG1/2 mutations: A case report and querying the Exome Aggregation Consortium

    Pagina :690

    Attila Kumánovics, Yu Nee Lee, Devin W. Close, Emily M. Coonrod, Boglarka Ujhazi, Karin Chen, Daniel G. MacArthur, Gergely Krivan, Luigi D. Notarangelo, Jolan E. Walter

     
  • ·Assessment of wheezing frequency and viral etiology on childhood and adolescent asthma risk

    Pagina :692-694

    Halie M. Anderson, Robert F. Lemanske, Michael D. Evans, Ronald E. Gangnon, Tressa Pappas, Kris Grindle, Yury A. Bochkov, James E. Gern, Daniel J. Jackson

     
  • ·Increased immune reactivity to central nervous system–derived naturally presented peptides in patients with active multiple sclerosis

    Pagina :694

    Christine Riedhammer, Dagmar Halbritter, Robert Weissert

     
  • ·IL-17 enhances the migration of B cells during asthma by inducing CXCL13 chemokine production in structural lung cells

    Pagina :696

    Roua Al-Kufaidy, Alejandro Vazquez-Tello, Ahmed S. BaHammam, Saleh Al-Muhsen, Qutayba Hamid, Rabih Halwani

     
  • ·Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois

    Pagina :699

    Bruce K. Tan, Aiko I. Klingler, Julie A. Poposki, Whitney W. Stevens, Anju T. Peters, Lydia A. Suh, James Norton, Roderick G. Carter, Kathryn E. Hulse, Kathleen E. Harris, Leslie C. Grammer, Robert P. Schleimer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Robert C. Kern, Atsushi Kato

     
  • ·Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect

    Pagina :703

    Peter D. Sly, Julie Varghese, Farhana Noor, Mimi L.K. Tang, Ingrid Laing, Steve Oo, Franciska Prastanti, Peter N. LeSouef, Patrick G. Holt

     
  • ·Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone

    Pagina :705

    Vladimir Ramirez-Carrozzi, Arivazhagan Sambandam, Meijuan Zhou, Donghong Yan, Jing Kang, Xiumin Wu, Eric Suto, Miriam Baca, Cary Austin, Min Xu, Wyne Lee, Rajita Pappu

     
  • ·Human milk oligosaccharides and development of cow's milk allergy in infants

    Pagina :708

    Antti E. Seppo, Chloe A. Autran, Lars Bode, Kirsi M. Järvinen

     

• Correspondence

  • ·A possible differential role of autophagy in asthma?

    Pagina :712

    Ulaganathan Mabalirajan

    
  • ·Reply

    Pagina :712-713

    Hadi Maazi, Yuzo Suzuki, Jae Jung, Omid Akbari

    
  • ·Proficient DNA repair in house dust mite–induced asthma?

    Pagina :713-714

    Rakhshinda Rehman, Ulaganathan Mabalirajan

    
  • ·Correction

    Pagina :714