Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :5A

    
• • ·Table of Contents

    Pagina :8A

    
• • ·Editorial Board

    Pagina :30A

    

• Reader services

  • ·Information for Readers

    Pagina :31A

    
  • ·News & Notes

    Pagina :32A

    Mappa Mappa  
  • ·CME Activities Calendar

    Pagina :36A

    Mappa Mappa

• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :1629-1630

    Marc E. Rothenberg, Jean Bousquet

    Mappa Mappa  

• Reviews and feature articles

  • ·Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases

    Pagina :1631-1645

    Hans C. Oettgen

    Riassunto Riassunto Mappa Mappa  
  • ·Identification of IgE

    Pagina :1646-1650

    Kimishige Ishizaka, Teruko Ishizaka

    Riassunto Riassunto Mappa Mappa  
  • ·Role of IgE in autoimmunity

    Pagina :1651-1661

    Miguel A. Sanjuan, Divya Sagar, Roland Kolbeck

    Riassunto Riassunto Mappa Mappa  
  • ·IgE in the diagnosis and treatment of allergic disease

    Pagina :1662-1670

    Thomas A.E. Platts-Mills, Alexander J. Schuyler, Elizabeth A. Erwin, Scott P. Commins, Judith A. Woodfolk

    Riassunto Riassunto Mappa Mappa  
  • ·The discovery of IgE

    Pagina :1671-1673

    S.G.O. Johansson

    Riassunto Riassunto  
  • ·Human IgE-independent systemic anaphylaxis

    Pagina :1674-1680

    Fred D. Finkelman, Marat V. Khodoun, Richard Strait

    Riassunto Riassunto Mappa Mappa  
  • ·Advances and highlights in mechanisms of allergic disease in 2015

    Pagina :1681-1696

    Paulina Wawrzyniak, Cezmi A. Akdis, Fred D. Finkelman, Marc E. Rothenberg

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors' Choice

    Pagina :1697-1698

    Cezmi A. Akdis, Zuhair K. Ballas, Associate Editors of the JACI

    Mappa Mappa  

• Asthma and lower airway disease

  • ·?-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk

    Pagina :1699

    Tabea Brick, Yvonne Schober, Christian Böcking, Juha Pekkanen, Jon Genuneit, Georg Loss, Jean-Charles Dalphin, Josef Riedler, Roger Lauener, Wolfgang Andreas Nockher, Harald Renz, Outi Vaarala, Charlotte Braun-Fahrländer, Erika von Mutius, Markus Johannes Ege, Petra Ina Pfefferle, PASTURE study group, A. Karvonen, P. Tiittanen, M.-L. Dalphin, B. Schaub, M. Depner, S. Illi, M. Kabesch

    Riassunto Riassunto Mappa Mappa  
  • ·Forced midexpiratory flow between 25% and 75% of forced vital capacity is associated with long-term persistence of asthma and poor asthma outcomes

    Pagina :1709

    Valérie Siroux, Anne Boudier, Maïa Dolgopoloff, Sébastien Chanoine, Jean Bousquet, Frederic Gormand, Jocelyne Just, Nicole Le Moual, Rachel Nadif, Christophe Pison, Raphaëlle Varraso, Regis Matran, Isabelle Pin

    Riassunto Riassunto Mappa Mappa  
  • ·Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients

    Pagina :1717

    Thomas Trian, Benoit Allard, Annaig Ozier, Elise Maurat, Isabelle Dupin, Matthieu Thumerel, Olga Ousova, Jennifer Gillibert-Duplantier, Valérie Le Morvan, Hugues Begueret, Pierre-Olivier Girodet, Roger Marthan, Patrick Berger

    Riassunto Riassunto Mappa Mappa  
  • ·Prothrombotic state in patients with severe and prednisolone-dependent asthma

    Pagina :1727-1732

    Marlous M.S. Sneeboer, Christof J. Majoor, Anne de Kievit, Joost C.M. Meijers, Tom van der Poll, Pieter W. Kamphuisen, Elisabeth H. Bel

    Riassunto Riassunto Mappa Mappa  
  • ·Got milk? Understanding the farm milk effect in allergy and asthma prevention

    Pagina :1707-1708

    Joyce E. Yu, Rachel L. Miller

    

• Rhinitis, sinusitis, and upper airway disease

  • ·Randomized phase 1 study of the phosphatidylinositol 3-kinase ? inhibitor idelalisib in patients with allergic rhinitis

    Pagina :1733-1741

    Friedrich Horak, Kamal D. Puri, Bart H. Steiner, Leanne Holes, Guan Xing, Petra Zieglmayer, René Zieglmayer, Patrick Lemell, Albert Yu

    Riassunto Riassunto Mappa Mappa  

• Atopic dermatitis and skin disease

  • ·Omalizumab for the treatment of chronic spontaneous urticaria: A meta-analysis of randomized clinical trials

    Pagina :1742

    Zuo-Tao Zhao, Chun-Mei Ji, Wen-Jun Yu, Ling Meng, Tomasz Hawro, Ji-Fu Wei, Marcus Maurer

    Riassunto Riassunto Mappa Mappa  

• Food, drug, insect sting allergy, and anaphylaxis

  • ·The component-specific to total IgE ratios do not improve peanut and hazelnut allergy diagnoses

    Pagina :1751

    Linus Grabenhenrich, Lars Lange, Magdalena Härtl, Birgit Kalb, Mandy Ziegert, Antje Finger, Neda Harandi, Ruppert Schlags, Monika Gappa, Letizia Puzzo, Volker Stephan, Thomas Heigele, Susanne Büsing, Hagen Ott, Bodo Niggemann, Kirsten Beyer

    Riassunto Riassunto Mappa Mappa  
  • ·Peanut T-cell epitope discovery: Ara h 1

    Pagina :1764

    Manish Ramesh, Araya Yuenyongviwat, George N. Konstantinou, Jay Lieberman, Mariona Pascal, Madhan Masilamani, Hugh A. Sampson

    Riassunto Riassunto Mappa Mappa  
  • ·A call to improve standards for reporting of diagnostic test research in allergy

    Pagina :1761-1763

    Corinne A. Keet

     

• Immune deficiencies, infection, and systemic immune disorders

  • ·No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine

    Pagina :1772

    Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J. Pollard, Fiona M. Russell, Edward K. Mulholland

    Riassunto Riassunto Mappa Mappa  
  • ·Unbiased targeted next-generation sequencing molecular approach for primary immunodeficiency diseases

    Pagina :1780-1787

    Hamoud Al-Mousa, Mohamed Abouelhoda, Dorota M. Monies, Nada Al-Tassan, Abdulaziz Al-Ghonaium, Bandar Al-Saud, Hasan Al-Dhekri, Rand Arnaout, Saleh Al-Muhsen, Nazema Ades, Sahar Elshorbagi, Sulaiman Al Gazlan, Farrukh Sheikh, Majed Dasouki, Lina El-Baik, Tanzeil Elamin, Amal Jaber, Omnia Kheir, Mohamed El-Kalioby, Shazia Subhani, Eman Al Idrissi, Mofareh Al-Zahrani, Maryam Alhelale, Noukha Alnader, Afaf Al-Otaibi, Rana Kattan, Khalid Al Abdelrahman, Muna M. Al Breacan, Faisal S. Bin Humaid, Salma Majid Wakil, Fadi Alzayer, Haya Al-Dusery, Tariq Faquih, Safa Al-Hissi, Brian F. Meyer, Abbas Hawwari

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy and clinical immunology

  • ·Changes in IgE sensitization and total IgE levels over 20 years of follow-up

    Pagina :1788

    André F.S. Amaral, Roger B. Newson, Michael J. Abramson, Josep M. Antó, Roberto Bono, Angelo G. Corsico, Roberto de Marco, Pascal Demoly, Bertil Forsberg, Thorarinn Gislason, Joachim Heinrich, Ismael Huerta, Christer Janson, Rain Jõgi, Jeong-Lim Kim, José Maldonado, Jesús Martinez-Moratalla Rovira, Catherine Neukirch, Dennis Nowak, Isabelle Pin, Nicole Probst-Hensch, Chantal Raherison-Semjen, Cecilie Svanes, Isabel Urrutia Landa, Ronald van Ree, Serge A. Versteeg, Joost Weyler, Jan-Paul Zock, Peter G.J. Burney, Deborah L. Jarvis

    Riassunto Riassunto Mappa Mappa  
  • ·Airway lipoxin A₄/formyl peptide receptor 2–lipoxin receptor levels in pediatric patients with severe asthma

    Pagina :1796-1806

    Rosalia Gagliardo, Delphine Gras, Stefania La Grutta, Pascal Chanez, Caterina Di Sano, Giusy D. Albano, Isabelle Vachier, Angela M. Montalbano, Giulia Anzalone, Anna Bonanno, Loredana Riccobono, Mark Gjomarkaj, Mirella Profita

    Riassunto Riassunto Mappa Mappa  
  • ·Cytometry by time-of-flight immunophenotyping identifies a blood Sjögren's signature correlating with disease activity and glandular inflammation

    Pagina :1809

    Michael Mingueneau, Saida Boudaoud, Scott Haskett, Taylor L. Reynolds, Gaetane Nocturne, Elizabeth Norton, Xueli Zhang, Myrtha Constant, Daniel Park, Wenting Wang, Thierry Lazure, Christine Le Pajolec, Ayla Ergun, Xavier Mariette

    Riassunto Riassunto Mappa Mappa  
  • ·Deficiency of plasminogen activator inhibitor 2 in plasma of patients with hereditary angioedema with normal C1 inhibitor levels

    Pagina :1822

    Kusumam Joseph, Baby G. Tholanikunnel, Bethany Wolf, Konrad Bork, Allen P. Kaplan

    Riassunto Riassunto Mappa Mappa  
  • ·The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases

    Pagina :1830-1840

    Jamie L. Harden, Steven M. Lewis, Samantha R. Lish, Mayte Suárez-Fariñas, Daniel Gareau, Tim Lentini, Leanne M. Johnson-Huang, James G. Krueger, Michelle A. Lowes

    Riassunto Riassunto Mappa Mappa   
  • ·The mannose receptor negatively modulates the Toll-like receptor 4–aryl hydrocarbon receptor–indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization

    Pagina :1841

    Fabián Salazar, Laurence Hall, Ola H. Negm, Dennis Awuah, Patrick J. Tighe, Farouk Shakib, Amir M. Ghaemmaghami

    Riassunto Riassunto Mappa Mappa  
  • ·Role of IL-4 receptor ?–positive CD4⁺ T cells in chronic airway hyperresponsiveness

    Pagina :1852

    Frank Kirstein, Natalie E. Nieuwenhuizen, Jaisubash Jayakumar, William G.C. Horsnell, Frank Brombacher

    Riassunto Riassunto Mappa Mappa  
  • ·IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3

    Pagina :1863

    Avanti Desai, Mi-Yeon Jung, Ana Olivera, Alasdair M. Gilfillan, Calman Prussin, Arnold S. Kirshenbaum, Michael A. Beaven, Dean D. Metcalfe

    Riassunto Riassunto Mappa Mappa  
  • ·Rapid recruitment of CD14⁺ monocytes in experimentally induced allergic rhinitis in human subjects

    Pagina :1872

    Ibon Eguíluz-Gracia, Anthony Bosco, Ralph Dollner, Guro Reinholt Melum, Maria H. Lexberg, Anya C. Jones, Sinan Ahmed Dheyauldeen, Patrick G. Holt, Espen S. Bækkevold, Frode Lars Jahnsen

    Riassunto Riassunto Mappa Mappa  
  • ·Could relative abundance of airway lipoxins be the clue to restore corticosteroid sensitivity in severe asthma?

    Pagina :1807-1808

    Nurlan Dauletbaev, Larry C. Lands

    

• Letters to the Editor

  • ·Panimmunoglobulin and IgE-selective extracorporeal immunoadsorption in patients with severe atopic dermatitis

    Pagina :1882

    Kristian Reich, Julia Deinzer, Anne-Kathrin Fiege, Valerie von Gruben, Anna-Lena Sack, Alice Thraen, Peter Weisenseel, Kristine Breuer, Stefan Jäckle, Markus Meier

     
  • ·Persistence of the IgE repertoire in birch pollen allergy

    Pagina :1884

    Manuel Otte, Vera Mahler, Andrea Kerpes, Oliver Pabst, David Voehringer

     
  • ·Allergen immunotherapy: No evidence of infectious risk

    Pagina :1887-1888

    Diana S. Balekian, Aleena Banerji, Kimberly G. Blumenthal, Carlos A. Camargo, Aidan A. Long

     
  • ·Increasing visits for anaphylaxis and the benefits of early epinephrine administration: A 4-year study at a pediatric emergency department in Montreal, Canada

    Pagina :1888

    Elana Hochstadter, Ann Clarke, Sarah De Schryver, Sebastien La Vieille, Reza Alizadehfar, Lawrence Joseph, Harley Eisman, Moshe Ben-Shoshan

    
  • ·Limited thymic recovery after extracorporeal photopheresis in a low-body-weight patient with acute graft-versus-host disease of the skin

    Pagina :1890

    Benjamin Beattie, David Cole, Lindsay Nicholson, Suzy Leech, Aileen Taylor, Holly Robson, Julie Guest, Xiao Nong Wang, Andrew R. Gennery

     
  • ·microRNA in native and processed cow's milk and its implication for the farm milk effect on asthma

    Pagina :1893

    Benedikt Kirchner, Michael W. Pfaffl, Joseph Dumpler, Erika von Mutius, Markus J. Ege

     
  • ·Food allergies can persist after myeloablative hematopoietic stem cell transplantation in dedicator of cytokinesis 8–deficient patients

    Pagina :1895

    Corinne S. Happel, Kelly D. Stone, Alexandra F. Freeman, Nirali N. Shah, Angela Wang, Jonathan J. Lyons, Pamela A. Guerrerio, Dennis D. Hickstein, Helen C. Su

     
  • ·Increased expression of nuclear factor of activated T cells 1 drives IL-9–mediated allergic asthma

    Pagina :1898

    Sonja Koch, Anna Graser, Hooman Mirzakhani, Theodor Zimmermann, Volker O. Melichar, Marco Wölfel, Damien C. Croteau-Chonka, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto

     
  • ·Sensitization of a child to Cyanobacteria after recreational swimming in a lake

    Pagina :1902

    Esmond N. Geh, Armah A. de la Cruz, Debajyoti Ghosh, Gerard Stelma, Jonathan A. Bernstein

     
  • ·Serum periostin is associated with type 2 immunity in severe asthma

    Pagina :1904

    Mats W. Johansson, Michael D. Evans, Gina M. Crisafi, Cécile T.J. Holweg, John G. Matthews, Nizar N. Jarjour

     
  • ·Regulatory T-cell–intrinsic amphiregulin is dispensable for suppressive function

    Pagina :1907-1909

    Katharine Carney, Yu-Mei (Ruby) Chang, Stephen Wilson, Clare Calnan, Pala S. Reddy, Win-Yan Chan, Timothy Gilmartin, Gilberto Hernandez, Lana Schaffer, Steven R. Head, Joanne Morley, Amanda de Mestre, Karen Affleck, Oliver A. Garden

      
  • ·Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota

    Pagina :1909

    Jonathan M. Mansbach, Kohei Hasegawa, David M. Henke, Nadim J. Ajami, Joseph F. Petrosino, Chad A. Shaw, Pedro A. Piedra, Ashley F. Sullivan, Janice A. Espinola, Carlos A. Camargo

     
  • ·Pioglitazone as a novel therapeutic approach in chronic granulomatous disease

    Pagina :1913

    Maddalena Migliavacca, Andrea Assanelli, Francesca Ferrua, Maria Pia Cicalese, Alessandra Biffi, Marta Frittoli, Paolo Silvani, Giovanna Chidini, Edoardo Calderini, Anna Mandelli, Anna Camporesi, Raffaella Milani, Giada Farinelli, Roberto Nicoletti, Fabio Ciceri, Alessandro Aiuti, Maria Ester Bernardo

     

• Correspondence

  • ·Selecting the correct treatment for asthma adherence studies

    Pagina :1916

    Andrew G. Weinstein

    
  • ·Reply

    Pagina :1916

    William C. Anderson, Stanley J. Szelfer

    

• Correction

  • ·Correction

    Pagina :1917