Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :1A

    
• • ·Table of Contents

    Pagina :5A

    
• • ·Editorial Board

    Pagina :22A

    

• Reader services

  • ·Information for Readers

    Pagina :24A

    
  • ·News & Notes

    Pagina :26A

    Mappa Mappa  
  • ·CME Activities Calendar

    Pagina :30A

    Mappa Mappa

• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :217-218

    Marc E. Rothenberg, Jean Bousquet

    Mappa Mappa  

• Reviews and feature articles

  • ·Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response

    Pagina :219-234

    Katie D. White, Wen-Hung Chung, Shuen-Iu Hung, Simon Mallal, Elizabeth J. Phillips

    Riassunto Riassunto Mappa Mappa   
  • ·Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response

    Pagina :235

    
  • ·New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity

    Pagina :236-244

    Munir Pirmohamed, David A. Ostrov, B. Kevin Park

    Riassunto Riassunto Mappa Mappa  
  • ·Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug–related urticaria and angioedema

    Pagina :245-251

    Marek L. Kowalski, Katharine Woessner, Marek Sanak

    Riassunto Riassunto Mappa Mappa  
  • ·New approaches for predicting T cell–mediated drug reactions: A role for inducible and potentially preventable autoimmunity

    Pagina :252-257

    Aaron W. Michels, David A. Ostrov

    Riassunto Riassunto Mappa Mappa  
  • ·Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants

    Pagina :258-261

    David M. Fleischer, Scott Sicherer, Matthew Greenhawt, Dianne Campbell, Edmond Chan, Antonella Muraro, Susanne Halken, Yitzhak Katz, Motohiro Ebisawa, Lawrence Eichenfield, Hugh Sampson, Gideon Lack, George Du Toit, Graham Roberts, Henry Bahnson, Mary Feeney, Jonathan Hourihane, Jonathan Spergel, Michael Young, Amal As'aad, Katrina Allen, Susan Prescott, Sandeep Kapur, Hirohisa Saito, Ioana Agache, Cezmi A. Akdis, Hasan Arshad, Kirsten Beyer, Anthony Dubois, Philippe Eigenmann, Monserrat Fernandez-Rivas, Kate Grimshaw, Karin Hoffman-Sommergruber, Arne Host, Susanne Lau, Liam O'Mahony, Clare Mills, Nikolaus Papadopoulos, Carina Venter, Nancy Agmon-Levin, Aaron Kessel, Richard Antaya, Beth Drolet, Lanny Rosenwasser

    Riassunto Riassunto Mappa Mappa
  • ·Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy

    Pagina :262

    Lisa M. Wheatley, Marshall Plaut, Julie M. Schwaninger, Aleena Banerji, Mariana Castells, Fred D. Finkelman, Gerald J. Gleich, Emma Guttman-Yassky, Simon A.K. Mallal, Dean J. Naisbitt, David A. Ostrov, Elizabeth J. Phillips, Werner J. Pichler, Thomas A.E. Platts-Mills, Jean-Claude Roujeau, Lawrence B. Schwartz, Lauren A. Trepanier

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors' Choice

    Pagina :272-273

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

    Mappa Mappa  

• Asthma and lower airway disease

  • ·Measuring the corticosteroid responsiveness endophenotype in asthmatic patients

    Pagina :274

    George L. Clemmer, Ann Chen Wu, Bernard Rosner, Michael J. McGeachie, Augusto A. Litonjua, Kelan G. Tantisira, Scott T. Weiss

    Riassunto Riassunto Mappa Mappa  
  • ·Sex-related differences in pulmonary physiologic outcome measures in a high-risk birth cohort

    Pagina :282-287

    Amy O. Thomas, Daniel J. Jackson, Michael D. Evans, Victoria Rajamanickam, Ronald E. Gangnon, Sean B. Fain, Ronald L. Sorkness, Adesua Y. Okupa, Alex Thomas, James E. Gern, Robert F. Lemanske

    Riassunto Riassunto Mappa Mappa  
  • ·Risk of an asthma exacerbation after bariatric surgery in adults

    Pagina :288

    Kohei Hasegawa, Yusuke Tsugawa, Yuchiao Chang, Carlos A. Camargo

    Riassunto Riassunto Mappa Mappa  
  • ·Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility

    Pagina :295

    Eric B. Brandt, Jocelyn M. Biagini Myers, Thomas H. Acciani, Patrick H. Ryan, Umasundari Sivaprasad, Brandy Ruff, Grace K. LeMasters, David I. Bernstein, James E. Lockey, Timothy D. LeCras, Gurjit K. Khurana Hershey

    Riassunto Riassunto Mappa Mappa  
  • ·Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma

    Pagina :304

    Erick Forno, Yueh-Ying Han, Radhika H. Muzumdar, Juan C. Celedón

    Riassunto Riassunto Mappa Mappa  
  • ·Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33

    Pagina :312

    Susana Castanhinha, Rebekah Sherburn, Simone Walker, Atul Gupta, Cara J. Bossley, James Buckley, Nicola Ullmann, Ruth Grychtol, Gaynor Campbell, Marco Maglione, Sergio Koo, Louise Fleming, Lisa Gregory, Robert J. Snelgrove, Andrew Bush, Clare M. Lloyd, Sejal Saglani

    Riassunto Riassunto Mappa Mappa  
  • ·Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

    Pagina :323-333

    Timothy S.C. Hinks, Xiaoying Zhou, Karl J. Staples, Borislav D. Dimitrov, Alexander Manta, Tanya Petrossian, Pek Y. Lum, Caroline G. Smith, Jon A. Ward, Peter H. Howarth, Andrew F. Walls, Stephan D. Gadola, Ratko Djukanovi?

    Riassunto Riassunto Mappa Mappa   

• Rhinitis, sinusitis, and upper airway disease

  • ·Sinus microbiota varies among chronic rhinosinusitis phenotypes and predicts surgical outcome

    Pagina :334

    Vijay R. Ramakrishnan, Leah J. Hauser, Leah M. Feazel, Diana Ir, Charles E. Robertson, Daniel N. Frank

    Riassunto Riassunto Mappa Mappa  
  • ·Staphylococcal protein A–formulated immune complexes suppress enterotoxin-induced cellular responses in nasal polyps

    Pagina :343

    Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Takenori Haruna, Takaya Higaki, Yasuyuki Noyama, Sei-ichiro Makihara, Kengo Kanai, Kazunori Nishizaki

    Riassunto Riassunto Mappa Mappa  

• Atopic dermatitis and skin disease

  • ·Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis

    Pagina :351

    Shunya Mashiko, Salim Bouguermouh, Manuel Rubio, Nobuyasu Baba, Robert Bissonnette, Marika Sarfati

    Riassunto Riassunto Mappa Mappa  
  • ·Incidence rates of atopic dermatitis, asthma, and allergic rhinoconjunctivitis in Danish and Swedish children

    Pagina :360

    Lonny Henriksen, Jacob Simonsen, Ann Haerskjold, Marie Linder, Helle Kieler, Simon Francis Thomsen, Lone Graff Stensballe

    Riassunto Riassunto Mappa Mappa   

• Food, drug, insect sting allergy, and anaphylaxis

  • ·Time trends in Australian hospital anaphylaxis admissions in 1998-1999 to 2011-2012

    Pagina :367-375

    Raymond James Mullins, Keith B.G. Dear, Mimi L.K. Tang

    Riassunto Riassunto Mappa Mappa  
  • ·Safety of live attenuated influenza vaccine in atopic children with egg allergy

    Pagina :376-381

    Paul J. Turner, Jo Southern, Nick J. Andrews, Elizabeth Miller, Michel Erlewyn-Lajeunesse, SNIFFLE Study Investigators ? ChristineDoyleGeorgeDu ToitMichelErlewyn-LajeunesseRoisinFitzsimonsPaul T.HeathStephen M.HughesLouiseMichealisJürgenSchwarzMatthew D.SnapeGaryStiefelHuw M.ThomasPaul J.Turner, Christine Doyle, George Du Toit, Michel Erlewyn-Lajeunesse, Roisin Fitzsimons, Paul T. Heath, Stephen M. Hughes, Louise Michealis, Jürgen Schwarz, Matthew D. Snape, Gary Stiefel, Huw M. Thomas, Paul J. Turner

    Riassunto Riassunto Mappa Mappa  
  • ·Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

    Pagina :382-391

    Mareen R. Datema, Laurian Zuidmeer-Jongejan, Riccardo Asero, Laura Barreales, Simona Belohlavkova, Frédéric de Blay, Peter Bures, Michael Clausen, Ruta Dubakiene, David Gislason, Monika Jedrzejczak-Czechowicz, Marek L. Kowalski, André C. Knulst, Tanya Kralimarkova, Thuy-My Le, Alison Lovegrove, Justin Marsh, Nikolaos G. Papadopoulos, Todor Popov, Náyade del Prado, Ashok Purohit, Gerald Reese, Isabel Reig, Suranjith L. Seneviratne, Athanasios Sinaniotis, Serge A. Versteeg, Stefan Vieths, Aeilko H. Zwinderman, Clare Mills, Jonas Lidholm, Karin Hoffmann-Sommergruber, Montserrat Fernández-Rivas, Barbara Ballmer-Weber, Ronald van Ree

    Riassunto Riassunto Mappa Mappa   

• Immune deficiencies, infection, and systemic immune disorders

  • ·?₂-Microglobulin deficiency causes a complex immunodeficiency of the innate and adaptive immune system

    Pagina :392-401

    Ömür Ardeniz, Susanne Unger, Hüseyin Onay, Sandra Ammann, Caroline Keck, Corina Cianga, Bengü Gerçeker, Bianca Martin, Ilka Fuchs, Ulrich Salzer, Aydan ?kincio?ullar?, Deniz Gülo?lu, Tu?rul Dereli, Robert Thimme, Stephan Ehl, Klaus Schwarz, Annette Schmitt-Graeff, Petru Cianga, Paul Fisch, Klaus Warnatz

    Riassunto Riassunto Mappa Mappa   
  • ·The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency

    Pagina :402-412

    Karin R. Engelhardt, Michael E. Gertz, Sevgi Keles, Alejandro A. Schäffer, Elena C. Sigmund, Cristina Glocker, Shiva Saghafi, Zahra Pourpak, Ruben Ceja, Atfa Sassi, Laura E. Graham, Michel J. Massaad, Fethi Mellouli, Imen Ben-Mustapha, Monia Khemiri, Sara Sebnem Kilic, Amos Etzioni, Alexandra F. Freeman, Jens Thiel, Ilka Schulze, Waleed Al-Herz, Ayse Metin, Özden Sanal, Ilhan Tezcan, Mehdi Yeganeh, Tim Niehues, Gregor Dueckers, Sebastian Weinspach, Turkan Patiroglu, Ekrem Unal, Majed Dasouki, Mustafa Yilmaz, Ferah Genel, Caner Aytekin, Necil Kutukculer, Ayper Somer, Mehmet Kilic, Ismail Reisli, Yildiz Camcioglu, Andrew R. Gennery, Andrew J. Cant, Alison Jones, Bobby H. Gaspar, Peter D. Arkwright, Maria C. Pietrogrande, Zeina Baz, Salem Al-Tamemi, Vassilios Lougaris, Gerard Lefranc, Andre Megarbane, Jeannette Boutros, Nermeen Galal, Mohamed Bejaoui, Mohamed-Ridha Barbouche, Raif S. Geha, Talal A. Chatila, Bodo Grimbacher

    Riassunto Riassunto Mappa Mappa   

• Mechanisms of allergy and clinical immunology

  • ·Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin

    Pagina :413-422

    Giulia Fornasa, Katerina Tsilingiri, Flavio Caprioli, Fiorenzo Botti, Marina Mapelli, Stephan Meller, Andreas Kislat, Bernhard Homey, Antonio Di Sabatino, Angelica Sonzogni, Giuseppe Viale, Giuseppe Diaferia, Alessandro Gori, Renato Longhi, Giuseppe Penna, Maria Rescigno

    Riassunto Riassunto Mappa Mappa   
  • ·Culture medium from TNF-?–stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms

    Pagina :423

    Wenru Su, Qian Wan, Jingwen Huang, Longhui Han, Xiaoqing Chen, Guihua Chen, Nancy Olsen, Song Guo Zheng, Dan Liang

    Riassunto Riassunto Mappa Mappa  
  • ·T_H9 cells are required for tissue mast cell accumulation during allergic inflammation

    Pagina :433

    Sarita Sehra, Weiguo Yao, Evelyn T. Nguyen, Nicole L. Glosson-Byers, Nahid Akhtar, Baohua Zhou, Mark H. Kaplan

    Riassunto Riassunto Mappa Mappa  
  • ·Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor–notch signaling cascade

    Pagina :441-453

    Mingcan Xia, Loida Viera-Hutchins, Maria Garcia-Lloret, Magali Noval Rivas, Petra Wise, Sean A. McGhee, Zena K. Chatila, Nancy Daher, Constantinos Sioutas, Talal A. Chatila

    Riassunto Riassunto Mappa Mappa   
  • ·Cysteine oxidation impairs systemic glucocorticoid responsiveness in children with difficult-to-treat asthma

    Pagina :454

    Susan T. Stephenson, Lou Ann S. Brown, My N. Helms, Hongyan Qu, Sheena D. Brown, Milton R. Brown, Anne M. Fitzpatrick

    Riassunto Riassunto Mappa Mappa  
  • ·MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

    Pagina :462-473

    Jing Jing Li, Hock L. Tay, Steven Maltby, Yang Xiang, Fiona Eyers, Luke Hatchwell, Hong Zhou, Hamish D. Toop, Jonathan C. Morris, Parameswaran Nair, Joerg Mattes, Paul S. Foster, Ming Yang

    Riassunto Riassunto Mappa Mappa   

• Letters to the Editor

  • ·Promiscuous T-cell responses to drugs and drug-haptens

    Pagina :474

    Fiazia S. Yaseen, Katy Saide, Seung-Hyun Kim, Manal Monshi, Arun Tailor, Sally Wood, Xiaoli Meng, Rosalind Jenkins, Lee Faulkner, Ann K. Daly, Munir Pirmohamed, B. Kevin Park, Dean J. Naisbitt

     
  • ·Clinical application of whole-genome sequencing in patients with primary immunodeficiency

    Pagina :476

    Talal Mousallem, Thomas J. Urban, K. Melodi McSweeney, Sarah E. Kleinstein, Mingfu Zhu, Mehdi Adeli, Roberta E. Parrott, Joseph L. Roberts, Brian Krueger, Rebecca H. Buckley, David B. Goldstein

     
  • ·A novel mutation in ORAI1 presenting with combined immunodeficiency and residual T-cell function

    Pagina :479

    Janet Chou, Yousef R. Badran, Christina S.K. Yee, Wayne Bainter, Toshiro K. Ohsumi, Suleiman Al-Hammadi, Sung-Yun Pai, Stefan Feske, Raif S. Geha

     
  • ·The polyamine spermine promotes survival and activation of human eosinophils

    Pagina :482

    Pinja Ilmarinen, Eeva Moilanen, Jonas S. Erjefält, Hannu Kankaanranta

     
  • ·Somatic NOD2 mosaicism in Blau syndrome

    Pagina :484

    Jaime de Inocencio, Anna Mensa-Vilaro, Pilar Tejada-Palacios, Eugenia Enriquez-Merayo, Eva González-Roca, Giuliana Magri, Estibaliz Ruiz-Ortiz, Andrea Cerutti, Jordi Yagüe, Juan I. Aróstegui

     
  • ·Key stages of bone marrow B-cell maturation are defective in patients with common variable immunodeficiency disorders

    Pagina :487

    Consuelo Anzilotti, Anne-Kathrin Kienzler, Eduardo Lopez-Granados, Sarah Gooding, Benjamin Davies, Hemant Pandit, Mary Lucas, Andrew Price, Timothy Littlewood, Mirjam van der Burg, Smita Y. Patel, Helen Chapel

     
  • ·Antibody conjugates bispecific for intercellular adhesion molecule 1 and allergen prevent migration of allergens through respiratory epithelial cell layers

    Pagina :490

    Christoph Madritsch, Julia Eckl-Dorna, Katharina Blatt, Isabella Ellinger, Michael Kundi, Verena Niederberger, Peter Valent, Rudolf Valenta, Sabine Flicker

     
  • ·In vivo allergenic activity of a hypoallergenic mutant of the major fish allergen Cyp c 1 evaluated by means of skin testing

    Pagina :493

    Nikolaos Douladiris, Birgit Linhart, Ines Swoboda, Antonia Gstöttner, Emilia Vassilopoulou, Frank Stolz, Rudolf Valenta, Nikolaos G. Papadopoulos

     
  • ·Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases

    Pagina :495-497

    Gunda Herberth, Kirsten Offenberg, Ulrike Rolle-Kampczyk, Mario Bauer, Wolfgang Otto, Stefan Röder, Konrad Grützmann, Ulrich Sack, Jan-Christoph Simon, Michael Borte, Martin von Bergen, Irina Lehmann, LINA Study Group

      
  • ·The influence of asthma control on the severity of virus-induced asthma exacerbations

    Pagina :497

    David J. Jackson, Maria-Belen Trujillo-Torralbo, Jerico del-Rosario, Nathan W. Bartlett, Michael R. Edwards, Patrick Mallia, Ross P. Walton, Sebastian L. Johnston

     
  • ·The novel inhaled glucocorticoid receptor agonist GW870086X protects against adenosine-induced bronchoconstriction in asthma

    Pagina :501

    Brian R. Leaker, Brian O'Connor, Dave Singh, Peter J. Barnes

     
  • ·A new case of Fas-associated death domain protein deficiency and update on treatment outcomes

    Pagina :502

    Sinisa Savic, David Parry, Clive Carter, Colin Johnson, Clare Logan, Beatriz Morillo Gutierrez, Julian E. Thomas, Chris M. Bacon, Andrew Cant, Sophie Hambleton

     
  • ·Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone

    Pagina :505-507

    Chris Stockmann, Christopher A. Reilly, Bernhard Fassl, Roger Gaedigk, Flory Nkoy, Bryan Stone, Jessica K. Roberts, Derek A. Uchida, J. Steven Leeder, Catherine M.T. Sherwin, Michael G. Spigarelli, Garold S. Yost, Robert M. Ward

     
  • ·Whole-exome sequencing of Ethiopian patients with ichthyosis vulgaris and atopic dermatitis

    Pagina :507

    Fulya Taylan, Daniel Nilsson, Samina Asad, Agne Lieden, Carl-Fredrik Wahlgren, Mårten C.G. Winge, Kassahun Desalegn Bilcha, Magnus Nordenskjöld, Maria Bradley

    
  • ·Rhinovirus-induced bronchiolitis: Lack of association between virus genomic load and short-term outcomes

    Pagina :509

    Tuomas Jartti, Kohei Hasegawa, Jonathan M. Mansbach, Pedro A. Piedra, Carlos A. Camargo

     
  • ·Chronic rhinosinusitis is rare but bothersome in adolescents from a Swedish population-based cohort

    Pagina :512

    Marit Westman, Pär Stjärne, Anna Bergström, Inger Kull, Elina Toskala, Lars Olaf Cardell, Magnus Wickman, Mats Holmström

     

• Correspondence

  • ·Biomarkers to predict inhaled corticosteroid response

    Pagina :515

    Brian J. Lipworth

    
  • ·Reply

    Pagina :515-516

    Douglas C. Cowan, D. Robin Taylor, Suzy A.A. Comhair

    
  • ·Vitamin D and asthma

    Pagina :516

    Michele Columbo

    
  • ·Reply

    Pagina :516

    Jantina C. de Groot, Anneke ten Brinke, Elisabeth H.D. Bel

    
  • ·Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma: Are we sure?

    Pagina :516-517

    Komalkirti Apte, Sundeep Salvi

    
  • ·Reply

    Pagina :517-518

    Jantina C. de Groot, Anneke ten Brinke, Elisabeth H.D. Bel