Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :3A

    
• • ·Table of Contents

    Pagina :7A

    
• • ·Editorial Board

    Pagina :30A

    

• Reader services

  • ·Information for Readers

    Pagina :32A

    
  • ·News & Notes

    Pagina :34A

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  • ·CME Activities Calendar

    Pagina :38A

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :941-942

    Marc E. Rothenberg, Jean Bousquet, Patricia C. Fulkerson

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• Reviews and feature articles

  • ·Innate lymphoid cells and asthma

    Pagina :943-950

    Sanhong Yu, Hye Young Kim, Ya-Jen Chang, Rosemarie H. DeKruyff, Dale T. Umetsu

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  • ·Innate lymphoid cells and asthma

    Pagina :951

    
  • ·A molecular perspective on T_H2-promoting cytokine receptors in patients with allergic disease

    Pagina :952

    Martin J. Romeo, Rachana Agrawal, Anna Pomés, Judith A. Woodfolk

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  • ·Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts

    Pagina :961-966

    Medical Advisory Committee of the Immune Deficiency Foundation, William T. Shearer, Thomas A. Fleisher, Rebecca H. Buckley, Zuhair Ballas, Mark Ballow, R. Michael Blaese, Francisco A. Bonilla, Mary Ellen Conley, Charlotte Cunningham-Rundles, Alexandra H. Filipovich, Ramsay Fuleihan, Erwin W. Gelfand, Vivian Hernandez-Trujillo, Steven M. Holland, Richard Hong, Howard M. Lederman, Harry L. Malech, Stephen Miles, Luigi D. Notarangelo, Hans D. Ochs, Jordan S. Orange, Jennifer M. Puck, John M. Routes, E. Richard Stiehm, Kathleen Sullivan, Troy Torgerson, Jerry Winkelstein

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  • ·Advances in basic and clinical immunology in 2013

    Pagina :967-976

    Javier Chinen, Luigi D. Notarangelo, William T. Shearer

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• The Editors' choice

  • ·The Editors' Choice

    Pagina :977-978

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

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• Asthma and lower airway disease

  • ·Early-life determinants of asthma from birth to age 20 years: A German birth cohort study

    Pagina :979

    Linus B. Grabenhenrich, Hannah Gough, Andreas Reich, Nora Eckers, Fred Zepp, Oliver Nitsche, Johannes Forster, Antje Schuster, Dirk Schramm, Carl-Peter Bauer, Ute Hoffmann, John Beschorner, Petra Wagner, Renate Bergmann, Karl Bergmann, Paolo Maria Matricardi, Ulrich Wahn, Susanne Lau, Thomas Keil

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  • ·Efficacy and safety of an anti–IL-13 mAb in patients with severe asthma: A randomized trial

    Pagina :989

    Erika H. De Boever, Claire Ashman, Anthony P. Cahn, Nicholas W. Locantore, Phil Overend, Isabelle J. Pouliquen, Adrian P. Serone, Tracey J. Wright, Mair M. Jenkins, Inderpal S. Panesar, Sivayogan S. Thiagarajah, Sally E. Wenzel

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  • ·Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

    Pagina :997-1007

    Katherine J. Baines, Jodie L. Simpson, Lisa G. Wood, Rodney J. Scott, Naomi L. Fibbens, Heather Powell, Douglas C. Cowan, D. Robin Taylor, Jan O. Cowan, Peter G. Gibson

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  • ·Children with asthma by school age display aberrant immune responses to pathogenic airway bacteria as infants

    Pagina :1008

    Jeppe Madura Larsen, Susanne Brix, Anna Hammerich Thysen, Sune Birch, Morten Arendt Rasmussen, Hans Bisgaard

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  • ·The challenge of treating preschool asthma

    Pagina :1014-1015

    Miles Weinberger

    
  • ·The challenge of treating preschool wheezing episodes: The need for evidence-based approaches

    Pagina :1016-1017

    Avraham Beigelman, Robert S. Zeiger, H. William Kelly, Leonard B. Bacharier, Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute

    

• Rhinitis, sinusitis, and upper airway disease

  • ·Role of Art v 3 in pollinosis of patients allergic to Pru p 3

    Pagina :1018

    Jaime Sánchez-López, Leticia Tordesillas, Mariona Pascal, Rosa Muñoz-Cano, María Garrido, Maria Rueda, Ramón Vilella, Antonio Valero, Araceli Díaz-Perales, César Picado, Joan Bartra

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  • ·Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis

    Pagina :1026-1031

    Carmen Rondón, Paloma Campo, Maria Angeles Zambonino, Natalia Blanca-Lopez, Maria J. Torres, Lidia Melendez, Rocio Herrera, Rosa-Maria Guéant-Rodriguez, Jean-Louis Guéant, Gabriela Canto, Miguel Blanca

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• Atopic dermatitis and skin disease

  • ·Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis

    Pagina :1032-1040

    Howard Sofen, Stacy Smith, Robert T. Matheson, Craig L. Leonardi, Cesar Calderon, Carrie Brodmerkel, Katherine Li, Kim Campbell, Stanley J. Marciniak, Yasmine Wasfi, Yuhua Wang, Philippe Szapary, James G. Krueger

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  • ·Childhood atopic dermatitis and warts are associated with increased risk of infection: A US population-based study

    Pagina :1041-1047

    Jonathan I. Silverberg, Nanette B. Silverberg

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  • ·Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population

    Pagina :1048-1055

    Hui Mei Cheng, Sunmi Kim, Gyeong-Hun Park, Sung Eun Chang, Seunghyun Bang, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Kee Chan Moon

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• Food, drug, insect sting allergy, and anaphylaxis

  • ·Increased food diversity in the first year of life is inversely associated with allergic diseases

    Pagina :1056

    Caroline Roduit, Remo Frei, Martin Depner, Bianca Schaub, Georg Loss, Jon Genuneit, Petra Pfefferle, Anne Hyvärinen, Anne M. Karvonen, Josef Riedler, Jean-Charles Dalphin, Juha Pekkanen, Erika von Mutius, Charlotte Braun-Fahrländer, Roger Lauener, PASTURE study group ?

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  • ·Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions

    Pagina :1065-1074

    Asako Ichihara, Zhongzhi Wang, Masatoshi Jinnin, Yuki Izuno, Naoki Shimozono, Keitaro Yamane, Akihiko Fujisawa, Chikako Moriya, Satoshi Fukushima, Yuji Inoue, Hironobu Ihn

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  • ·Case fatality and population mortality associated with anaphylaxis in the United States

    Pagina :1075-1083

    Larry Ma, Theodore M. Danoff, Larry Borish

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  • ·Food diversity in infancy and the risk of childhood asthma and allergies

    Pagina :1084-1091

    Bright I. Nwaru, Hanna-Mari Takkinen, Minna Kaila, Maijaliisa Erkkola, Suvi Ahonen, Juha Pekkanen, Olli Simell, Riitta Veijola, Jorma Ilonen, Heikki Hyöty, Mikael Knip, Suvi M. Virtanen

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• Immune deficiencies, infection, and systemic immune disorders

  • ·Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID), leaky SCID, and Omenn syndrome: The Primary Immune Deficiency Treatment Consortium experience

    Pagina :1092-1098

    William T. Shearer, Elizabeth Dunn, Luigi D. Notarangelo, Christopher C. Dvorak, Jennifer M. Puck, Brent R. Logan, Linda M. Griffith, Donald B. Kohn, Richard J. O'Reilly, Thomas A. Fleisher, Sung-Yun Pai, Caridad A. Martinez, Rebecca H. Buckley, Morton J. Cowan

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  • ·A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency

    Pagina :1099

    Yu Nee Lee, Francesco Frugoni, Kerry Dobbs, Jolan E. Walter, Silvia Giliani, Andrew R. Gennery, Waleed Al-Herz, Elie Haddad, Francoise LeDeist, Jack H. Bleesing, Lauren A. Henderson, Sung-Yun Pai, Robert P. Nelson, Dalia H. El-Ghoneimy, Reem A. El-Feky, Shereen M. Reda, Elham Hossny, Pere Soler-Palacin, Ramsay L. Fuleihan, Niraj C. Patel, Michel J. Massaad, Raif S. Geha, Jennifer M. Puck, Paolo Palma, Caterina Cancrini, Karin Chen, Mauno Vihinen, Frederick W. Alt, Luigi D. Notarangelo

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  • ·Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development

    Pagina :1109

    Xiaomin Yu, Jorge R. Almeida, Sam Darko, Mirjam van der Burg, Suk See DeRavin, Harry Malech, Andrew Gennery, Ivan Chinn, Mary Louise Markert, Daniel C. Douek, Joshua D. Milner

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  • ·Recombination-activating gene 1 (Rag1)–deficient mice with severe combined immunodeficiency treated with lentiviral gene therapy demonstrate autoimmune Omenn-like syndrome

    Pagina :1116-1123

    Niek P. van Til, Roya Sarwari, Trudi P. Visser, Julia Hauer, Chantal Lagresle-Peyrou, Guus van der Velden, Vidyasagar Malshetty, Patricia Cortes, Arnaud Jollet, Olivier Danos, Barbara Cassani, Fang Zhang, Adrian J. Thrasher, Elena Fontana, Pietro L. Poliani, Marina Cavazzana, Monique M.A. Verstegen, Anna Villa, Gerard Wagemaker

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  • ·Similar recombination-activating gene (RAG) mutations result in similar immunobiological effects but in different clinical phenotypes

    Pagina :1124

    Hanna IJspeert, Gertjan J. Driessen, Michael J. Moorhouse, Nico G. Hartwig, Beata Wolska-Kusnierz, Krzysztof Kalwak, Anna Pituch-Noworolska, Irina Kondratenko, Joris M. van Montfrans, Ester Mejstrikova, Arjan C. Lankester, Anton W. Langerak, Dik C. van Gent, Andrew P. Stubbs, Jacques J.M. van Dongen, Mirjam van der Burg

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  • ·BCG vaccination in patients with severe combined immunodeficiency: Complications, risks, and vaccination policies

    Pagina :1134-1141

    Beatriz E. Marciano, Chiung-Yu Huang, Gyan Joshi, Nima Rezaei, Beatriz Costa Carvalho, Zoe Allwood, Aydan Ikinciogullari, Shereen M. Reda, Andrew Gennery, Vojtech Thon, Francisco Espinosa-Rosales, Waleed Al-Herz, Oscar Porras, Anna Shcherbina, Anna Szaflarska, ?ebnem Kiliç, Jose L. Franco, Andrea C. Gómez Raccio, Persio Roxo, Isabel Esteves, Nermeen Galal, Anete Sevciovic Grumach, Salem Al-Tamemi, Alisan Yildiran, Julio C. Orellana, Masafumi Yamada, Tomohiro Morio, Diana Liberatore, Yoshitoshi Ohtsuka, Yu-Lung Lau, Ryuta Nishikomori, Carlos Torres-Lozano, Juliana T.L. Mazzucchelli, Maria M.S. Vilela, Fabiola S. Tavares, Luciana Cunha, Jorge A. Pinto, Sara E. Espinosa-Padilla, Leticia Hernandez-Nieto, Reem A. Elfeky, Tadashi Ariga, Heike Toshio, Figen Dogu, Funda Cipe, Renata Formankova, M. Enriqueta Nuñez-Nuñez, Liliana Bezrodnik, Jose Gonçalo Marques, María I. Pereira, Viviana Listello, Mary A. Slatter, Zohreh Nademi, Danuta Kowalczyk, Thomas A. Fleisher, Graham Davies, Bénédicte Neven, Sergio D. Rosenzweig

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• Mechanisms of allergy and clinical immunology

  • ·Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, T_H2-inducing allergen exposures

    Pagina :1142

    Matthew J. Gold, Frann Antignano, Timotheus Y.F. Halim, Jeremy A. Hirota, Marie-Renee Blanchet, Colby Zaph, Fumio Takei, Kelly M. McNagny

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  • ·Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance

    Pagina :1149-1161

    Laurence Menard, Tineke Cantaert, Nicolas Chamberlain, Stuart G. Tangye, Sean Riminton, Joseph A. Church, Amy Klion, Charlotte Cunningham-Rundles, Kim E. Nichols, Eric Meffre

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  • ·Janus kinase 1/3 signaling pathways are key initiators of T_H2 differentiation and lung allergic responses

    Pagina :1162

    Shigeru Ashino, Katsuyuki Takeda, Hui Li, Vanessa Taylor, Anthony Joetham, Polly R. Pine, Erwin W. Gelfand

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  • ·Protein kinase C–dependent activation of Ca_V1.2 channels selectively controls human T_H2-lymphocyte functions

    Pagina :1175

    Virginie Robert, Emily Triffaux, Pierre-Emmanuel Paulet, Jean-Charles Guéry, Lucette Pelletier, Magali Savignac

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  • ·Prostaglandin D₂ activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on T_H2 cells

    Pagina :1184

    Luzheng Xue, Maryam Salimi, Isabel Panse, Jenny M. Mjösberg, Andrew N.J. McKenzie, Hergen Spits, Paul Klenerman, Graham Ogg

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  • ·Marked and persistent eosinophilia in the absence of clinical manifestations

    Pagina :1195

    Yun-Yun K. Chen, Paneez Khoury, JeanAnne M. Ware, Nicole C. Holland-Thomas, Jennifer L. Stoddard, Shakuntala Gurprasad, Amy J. Waldner, Amy D. Klion

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• Letters to the Editor

  • ·Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84

    Pagina :1203

    Taylor A. Doherty, David Scott, Hannah H. Walford, Naseem Khorram, Sean Lund, Rachel Baum, Jinny Chang, Peter Rosenthal, Andrew Beppu, Marina Miller, David H. Broide

     
  • ·Enrichment of the rare CD4⁺ ?? T-cell subset in patients with atypical CD3? deficiency

    Pagina :1205

    Beatriz Garcillán, Marina S. Mazariegos, Paul Fisch, Pieter C. Res, Miguel Muñoz-Ruiz, Juana Gil, Eduardo López-Granados, Edgar Fernández-Malavé, José R. Regueiro

     
  • ·Impact of Down syndrome on the performance of neonatal screening assays for severe primary immunodeficiency diseases

    Pagina :1208-1211

    Ruud H.J. Verstegen, Stephan Borte, Levinus A. Bok, Paul H.Th. van Zwieten, Ulrika von Döbeln, Lennart Hammarström, Esther de Vries

     
  • ·Lesson from hypomorphic recombination-activating gene (RAG) mutations: Why asymptomatic siblings should also be tested

    Pagina :1211

    Catharina Schuetz, Ulrich Pannicke, Eva-Maria Jacobsen, Siegfried Burggraf, Michael H. Albert, Manfred Hönig, Tim Niehues, Oliver Feyen, Stephan Ehl, Klaus-Michael Debatin, Wilhelm Friedrich, Ansgar S. Schulz, Klaus Schwarz

     
  • ·Kindlin-3–independent adhesion of neutrophils from patients with leukocyte adhesion deficiency type III

    Pagina :1215

    Edith van de Vijver, Anton T.J. Tool, Özden Sanal, Mualla Çetin, Sule Ünal, Selin Aytac, Karl Seeger, Daria Pagliara, Sergio Rutella, Timo K. van den Berg, Taco W. Kuijpers

     
  • ·Basal platelet-activating factor acetylhydrolase: Prognostic marker of severe Hymenoptera venom anaphylaxis

    Pagina :1218-1220

    Valerio Pravettoni, Marta Piantanida, Laura Primavesi, Stella Forti, Elide A. Pastorello

     
  • ·Nasopharyngeal Proteobacteria are associated with viral etiology and acute wheezing in children with severe bronchiolitis

    Pagina :1220

    Embriette R. Hyde, Joseph F. Petrosino, Pedro A. Piedra, Carlos A. Camargo, Janice A. Espinola, Jonathan M. Mansbach

     
  • ·A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency

    Pagina :1222

    Kathrin Pieper, Marta Rizzi, Matthaios Speletas, Cristian R. Smulski, Heiko Sic, Helene Kraus, Ulrich Salzer, Gina J. Fiala, Wolfgang W. Schamel, Vassilios Lougaris, Alessandro Plebani, Lennart Hammarstrom, Mike Recher, Anastasios E. Germenis, Bodo Grimbacher, Klaus Warnatz, Antonius G. Rolink, Pascal Schneider, Luigi D. Notarangelo, Hermann Eibel

     
  • ·Vaccine strain varicella-zoster virus–induced central nervous system vasculopathy as the presenting feature of DOCK8 deficiency

    Pagina :1225-1227

    Angela Sabry, Pia J. Hauk, Huie Jing, Helen C. Su, Nicholas V. Stence, David M. Mirsky, Maria A. Nagel, Jordan K. Abbott, Leonard L. Dragone, Jennifer Armstrong-Wells, Donna J. Curtis, Randall Cohrs, D. Scott Schmid, Don Gilden, Erwin W. Gelfand

      
  • ·Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages

    Pagina :1227

    Maya R. Karta, Lisa E. Wickert, Colleen S. Curran, Monica L. Gavala, Loren C. Denlinger, James E. Gern, Paul J. Bertics

     

• Correspondence

  • ·Eosinophil count and efficacy of omalizumab treatment

    Pagina :1231

    Josef Panasoff

    
  • ·Reply

    Pagina :1231

    Karin Rosén, William Busse

    
  • ·Exhaled breath condensate eicosanoid levels in asthma: Still questioned

    Pagina :1231-1232

    Wei-Jie Guan, Xue-Yan Zheng, Jin-Ping Zheng

    

• Corrections

  • ·Correction

    Pagina :1232

    
  • ·Correction

    Pagina :1232

    
  • ·Correction

    Pagina :1232

    
  • ·Correction

    Pagina :1232

    
  • ·Correction

    Pagina :1232

    

• Maintenance of Certification clinical management series

  • ·Influenza vaccination in asthmatic patients

    Pagina :1233

    Matthew J. Greenhawt

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