Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :3A

    
• • ·Table of Contents

    Pagina :6A

    
• • ·Editorial Board

    Pagina :27A

    

• Reader services

  • ·Information for Readers

    Pagina :28A

    
  • ·News & Notes

    Pagina :30A

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  • ·CME Activities Calendar

    Pagina :34A

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :605-606

    Marc E. Rothenberg, Jean Bousquet, Patricia C. Fulkerson

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  • ·A Special Thank-You to Our Reviewers

    Pagina :607-611

    

• Reviews and feature articles

  • ·Immunotherapy: What lies beyond

    Pagina :612-619

    Thomas B. Casale, Jeffrey R. Stokes

    Riassunto Riassunto Mappa Mappa  
  • ·Immunotherapy: What lies beyond

    Pagina :620

    
  • ·Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens

    Pagina :621-631

    Mübeccel Akdis, Cezmi A. Akdis

    Riassunto Riassunto Mappa Mappa  
  • ·Present state of Japanese cedar pollinosis: The national affliction

    Pagina :632

    Takechiyo Yamada, Hirohisa Saito, Shigeharu Fujieda

    Riassunto Riassunto Mappa Mappa  
  • ·Host-microbial interactions in patients with chronic rhinosinusitis

    Pagina :640

    Daniel L. Hamilos

    Riassunto Riassunto Mappa Mappa  
  • ·Advances in pediatric asthma in 2013: Coordinating asthma care

    Pagina :654-661

    Stanley J. Szefler

    Riassunto Riassunto Mappa Mappa

• The Editors' choice

  • ·The Editors' Choice

    Pagina :662-663

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

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• Asthma and lower airway disease

  • ·Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids

    Pagina :664

    Heung-Woo Park, Amber Dahlin, Szeman Tse, Qing Ling Duan, Brooke Schuemann, Fernando D. Martinez, Stephen P. Peters, Stanley J. Szefler, John J. Lima, Michiaki Kubo, Mayumi Tamari, Kelan G. Tantisira

    Riassunto Riassunto Mappa Mappa  
  • ·Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease

    Pagina :670

    Alex Poole, Cydney Urbanek, Celeste Eng, Jeoffrey Schageman, Sean Jacobson, Brian P. O'Connor, Joshua M. Galanter, Christopher R. Gignoux, Lindsey A. Roth, Rajesh Kumar, Sharon Lutz, Andrew H. Liu, Tasha E. Fingerlin, Robert A. Setterquist, Esteban G. Burchard, Jose Rodriguez-Santana, Max A. Seibold

    Riassunto Riassunto Mappa Mappa  
  • ·Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?^?

    Pagina :679

    Mark A. Birrell, Sara J. Bonvini, Eric Dubuis, Sarah A. Maher, Michael A. Wortley, Megan S. Grace, Kristof Raemdonck, John J. Adcock, Maria G. Belvisi

    Riassunto Riassunto Mappa Mappa  
  • ·Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis

    Pagina :688

    Mary F. Linehan, Ulugbek Nurmatov, Timothy L. Frank, Robert M. Niven, David N. Baxter, Aziz Sheikh

    Riassunto Riassunto Mappa Mappa  
  • ·Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma

    Pagina :696-703

    Takashi Kinoshita, Adrian Baatjes, Steven G. Smith, Benny Dua, Richard Watson, Tomotaka Kawayama, Mark Larche, Gail M. Gauvreau, Paul M. O’Byrne

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  • ·Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma

    Pagina :704

    Lorcan P. McGarvey, Claire A. Butler, Susan Stokesberry, Liam Polley, Stephen McQuaid, Hani’ah Abdullah, Sadaf Ashraf, Mary K. McGahon, Tim M. Curtis, Joe Arron, David Choy, Tim J. Warke, Peter Bradding, Madeleine Ennis, Alexander Zholos, Richard W. Costello, Liam G. Heaney

    Riassunto Riassunto Mappa Mappa  
  • ·Effects of prenatal community violence and ambient air pollution on childhood wheeze in an urban population

    Pagina :713

    Yueh-Hsiu Mathilda Chiu, Brent A. Coull, Michelle J. Sternthal, Itai Kloog, Joel Schwartz, Sheldon Cohen, Rosalind J. Wright

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  • ·Inhaled corticosteroid treatment modulates ZNF432 gene variant’s effect on bronchodilator response in asthmatics

    Pagina :723

    Ann Chen Wu, Blanca E. Himes, Jessica Lasky-Su, Augusto Litonjua, Stephen P. Peters, John Lima, Michiaki Kubo, Mayumi Tamari, Yusuke Nakamura, Weiliang Qiu, Scott T. Weiss, Kelan Tantisira

    Riassunto Riassunto Mappa Mappa  
  • ·Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients

    Pagina :729

    Sumit Gupta, Ruth Hartley, Umair T. Khan, Amisha Singapuri, Beverly Hargadon, William Monteiro, Ian D. Pavord, Ana R. Sousa, Richard P. Marshall, Deepak Subramanian, David Parr, James J. Entwisle, Salman Siddiqui, Vimal Raj, Christopher E. Brightling

    Riassunto Riassunto Mappa Mappa  
  • ·Can computed tomography help us identify asthmatic phenotypes?

    Pagina :739-740

    Ajay Sheshadri, Eric A. Hoffman, Mario Castro

    

• Rhinitis, sinusitis, and upper airway disease

  • ·Nasal mucus proteomic changes reflect altered immune responses and epithelial permeability in patients with allergic rhinitis

    Pagina :741-750

    Peter Valentin Tomazic, Ruth Birner-Gruenberger, Anita Leitner, Britta Obrist, Stefan Spoerk, Doris Lang-Loidolt

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  • ·Randomized, double-blind, placebo-controlled trial of standardized ragweed sublingual-liquid immunotherapy for allergic rhinoconjunctivitis

    Pagina :751-758

    Peter S. Creticos, Robert E. Esch, Peter Couroux, Deborah Gentile, Pina D'Angelo, Brad Whitlow, Michael Alexander, Terrance C. Coyne

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  • ·Identification and isolation of a Fel d 1–like molecule as a major rabbit allergen

    Pagina :759-766

    Christiane Hilger, Stéphanie Kler, Karthik Arumugam, Dominique Revets, Claude P. Muller, Catherine Charpentier, Christiane Lehners, Martine Morisset, François Hentges

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  • ·Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts

    Pagina :767

    Olena Gruzieva, Ulrike Gehring, Rob Aalberse, Raymond Agius, Rob Beelen, Heidrun Behrendt, Tom Bellander, Matthias Birk, Johan C. de Jongste, Elaine Fuertes, Joachim Heinrich, Gerard Hoek, Claudia Klümper, Gerard Koppelman, Michal Korek, Ursula Krämer, Sarah Lindley, Anna Mölter, Angela Simpson, Marie Standl, Marianne van Hage, Andrea von Berg, Alet Wijga, Bert Brunekreef, Göran Pershagen

    Riassunto Riassunto Mappa Mappa  
  • ·Methodological rigor and reporting of clinical practice guidelines in patients with allergic rhinitis: QuGAR study

    Pagina :777

    Agnieszka Padjas, Rohan Kehar, Sohaib Aleem, Filip Mejza, Jean Bousquet, Holger J. Schünemann, Jan L. Bro?ek

    Riassunto Riassunto Mappa Mappa  

• Atopic dermatitis and skin disease

  • ·Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects

    Pagina :784-789

    David J. Margolis, Jayanta Gupta, Andrea J. Apter, Tapan Ganguly, Ole Hoffstad, Maryte Papadopoulos, Tim R. Rebbeck, Nandita Mitra

    Riassunto Riassunto Mappa Mappa  

• Food, drug, insect sting allergy, and anaphylaxis

  • ·Health care use and serious infection prevalence associated with penicillin “allergy” in hospitalized patients: A cohort study

    Pagina :790-796

    Eric Macy, Richard Contreras

    Riassunto Riassunto Mappa Mappa
  • ·Penicillin allergy as a public health measure

    Pagina :797-798

    Roland Solensky

    

• Immune deficiencies, infection, and systemic immune disorders

  • ·B-cell development and functions and therapeutic options in adenosine deaminase–deficient patients

    Pagina :799

    Immacolata Brigida, Aisha V. Sauer, Francesca Ferrua, Stefania Giannelli, Samantha Scaramuzza, Valentina Pistoia, Maria Carmina Castiello, Barbara H. Barendregt, Maria Pia Cicalese, Miriam Casiraghi, Chiara Brombin, Jennifer Puck, Klaus Müller, Lucia Dora Notarangelo, Davide Montin, Joris M. van Montfrans, Maria Grazia Roncarolo, Elisabetta Traggiai, Jacques J.M. van Dongen, Mirjam van der Burg, Alessandro Aiuti

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  • ·Fatal combined immunodeficiency associated with heterozygous mutation in STAT1

    Pagina :807-817

    Nigel Sharfe, Amit Nahum, Andrea Newell, Harjit Dadi, Bo Ngan, Sergio L. Pereira, Jo-Anne Herbrick, Chaim M. Roifman

    Riassunto Riassunto Mappa Mappa  
  • ·Pattern recognition receptor-mediated cytokine response in infants across 4 continents^?

    Pagina :818

    Kinga K. Smolen, Candice E. Ruck, Edgardo S. Fortuno, Kevin Ho, Pedro Dimitriu, William W. Mohn, David P. Speert, Philip J. Cooper, Monika Esser, Tessa Goetghebuer, Arnaud Marchant, Tobias R. Kollmann

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy and clinical immunology

  • ·Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation^?

    Pagina :827

    Nazanin Farhadi, Laura Lambert, Chiara Triulzi, Peter J.M. Openshaw, Nadia Guerra, Fiona J. Culley

    Riassunto Riassunto Mappa Mappa  
  • ·Dissection of the IgE and T-cell recognition of the major group 5 grass pollen allergen Phl p 5

    Pagina :836

    Margarete Focke-Tejkl, Raffaela Campana, Renate Reininger, Christian Lupinek, Katharina Blatt, Peter Valent, Tea Pavkov-Keller, Walter Keller, Rudolf Valenta

    Riassunto Riassunto Mappa Mappa  
  • ·Development of cockroach immunotherapy by the Inner-City Asthma Consortium

    Pagina :846

    Robert A. Wood, Alkis Togias, Jeremy Wildfire, Cynthia M. Visness, Elizabeth C. Matsui, Rebecca Gruchalla, Gurjit Hershey, Andrew H. Liu, George T. O'Connor, Jacqueline A. Pongracic, Edward Zoratti, Frederic Little, Mark Granada, Suzanne Kennedy, Stephen R. Durham, Mohamed H. Shamji, William W. Busse

    Riassunto Riassunto Mappa Mappa  
  • ·Dendritic cell immunoreceptor: A novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells

    Pagina :853

    Amir H. Massoud, Madelaine Yona, Di Xue, Fazila Chouiali, Haydar Alturaihi, Aidan Ablona, Walid Mourad, Ciriaco A. Piccirillo, Bruce D. Mazer

    Riassunto Riassunto Mappa Mappa  
  • ·Regulation of T_H17 markers early in life through maternal farm exposure

    Pagina :864-871

    Anna Lluis, Nikolaus Ballenberger, Sabina Illi, Maximilian Schieck, Michael Kabesch, Thomas Illig, Isolde Schleich, Erika von Mutius, Bianca Schaub

    Riassunto Riassunto Mappa Mappa   
  • ·Specific immunotherapy modifies allergen-specific CD4⁺ T-cell responses in an epitope-dependent manner

    Pagina :872

    Erik Wambre, Jonathan H. DeLong, Eddie A. James, Nadia Torres-Chinn, Wolfgang Pfützner, Christian Möbs, Stephen R. Durham, Stephen J. Till, David Robinson, William W. Kwok

    Riassunto Riassunto Mappa Mappa  

• Letters to the Editor

  • ·Autoimmunity due to RAG deficiency and estimated disease incidence in RAG1/2 mutations

    Pagina :880

    Karin Chen, Wilfred Wu, Divij Mathew, Yuhua Zhang, Sarah K. Browne, Lindsey B. Rosen, Meghann P. McManus, Michael A. Pulsipher, Mark Yandell, John F. Bohnsack, Lynn B. Jorde, Luigi D. Notarangelo, Jolan E. Walter

     
  • ·Noneosinophilic responders with occupational asthma: A phenotype associated with a poor asthma prognosis

    Pagina :883

    Catherine Lemiere, Simone Chaboillez, Abraham Bohadana, Lucie Blais, Karim Maghni

     
  • ·Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure

    Pagina :885-888

    Salome Scholtens, Dirkje S. Postma, Miriam F. Moffatt, Sviatlana Panasevich, Raquel Granell, A. John Henderson, Erik Melén, Fredrik Nyberg, Göran Pershagen, Deborah Jarvis, Adaikalavan Ramasamy, Matthias Wjst, Cecilie Svanes, Emmanuelle Bouzigon, Florence Demenais, Francine Kauffmann, Valérie Siroux, Erika von Mutius, Markus Johannes Ege, Charlotte Braun-Fahrländer, Jon Genuneit, GABRIELA study group, Bert Brunekreef, Henriette A. Smit, Alet H. Wijga, Marjan Kerkhof, Ivan Curjuric, Medea Imboden, Gian A. Thun, Nicole Probst-Hensch, Maxim B. Freidin, Elena Iu. Bragina, I.A. Deev, V.P. Puzyrev, Denise Daley, Julie Park, Allan Becker, Moira Chan-Yeung, Anita L. Kozyrskyj, Peter Pare, Ingo Marenholz, Susanne Lau, Thomas Keil, Young-Ae Lee, Michael Kabesch, Cisca Wijmenga, Lude Franke, Ilja M. Nolte, Judith Vonk, Ashish Kumar, Martin Farrall, William O.C.M. Cookson, David P. Strachan, Gerard H. Koppelman, H. Marike Boezen

     
  • ·Genetic variation in T_H17 pathway genes, childhood asthma, and total serum IgE levels

    Pagina :888-891

    Maximilian Schieck, Sven Michel, Kathrin Suttner, Thomas Illig, Sonja Zeilinger, Andre Franke, Christian Vogelberg, Andrea von Berg, Albrecht Bufe, Andrea Heinzmann, Otto Laub, Ernst Rietschel, Burkhard Simma, Thomas Frischer, Jon Genuneit, Sebastian Kerzel, Michael Kabesch

      
  • ·T_H17 differentiation capacity develops within the first 3 months of life

    Pagina :891

    Krijn K. Dijkstra, Sanne B.E.A. Hoeks, Berent J. Prakken, Sytze de Roock

     
  • ·Penicillium marneffei infection and impaired IFN-? immunity in humans with autosomal-dominant gain-of-phosphorylation STAT1 mutations

    Pagina :894

    Pamela P.W. Lee, Huawei Mao, Wanling Yang, Koon-Wing Chan, Marco H.K. Ho, Tsz-Leung Lee, Jasper F.W. Chan, Patrick C.Y. Woo, Wenwei Tu, Yu-Lung Lau

     
  • ·Molecular and phenotypic abnormalities of B lymphocytes in patients with Wiskott-Aldrich syndrome

    Pagina :896

    Karen L. Simon, Stacie M. Anderson, Elizabeth K. Garabedian, Daniele Moratto, Robert A. Sokolic, Fabio Candotti

     
  • ·Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis

    Pagina :899

    Jinny E. Chang, Taylor A. Doherty, Rachel Baum, David Broide

     
  • ·CD49d-expressing neutrophils differentiate atopic from nonatopic individuals

    Pagina :901

    Jerome A. Sigua, Becky Buelow, Dorothy S. Cheung, Erika Buell, Desire Hunter, Meribeth Klancnik, Mitchell H. Grayson

     
  • ·Low-affinity allergen-specific IgE in cord blood and affinity maturation after birth

    Pagina :904

    Norio Kamemura, Norio Kawamoto, Ryosuke Nakamura, Reiko Teshima, Toshiyuki Fukao, Hiroshi Kido

     
  • ·CARD9 mutations linked to subcutaneous phaeohyphomycosis and T_H17 cell deficiencies

    Pagina :905

    Xiaowen Wang, Wenyan Wang, Zhimiao Lin, Xiaolin Wang, Ting Li, Jin Yu, Wei Liu, Zhongsheng Tong, Yonghao Xu, Junling Zhang, Liping Guan, Lanlan Dai, Yong Yang, Wenling Han, Ruoyu Li

     
  • ·Identification of Hymenoptera venom–allergic patients with negative specific IgE to venom extract by using recombinant allergens

    Pagina :909-910

    Liliana Cifuentes, Sebastian Vosseler, Simon Blank, Henning Seismann, Davide Pennino, Ulf Darsow, Reinhard Bredehorst, Johannes Ring, Martin Mempel, Edzard Spillner, Markus W. Ollert

    
  • ·Allergen microarray detects high prevalence of asymptomatic IgE sensitizations to tropical pollen-derived carbohydrates

    Pagina :910

    Clarissa R. Cabauatan, Christian Lupinek, Sandra Scheiblhofer, Richard Weiss, Margarete Focke-Tejkl, Prem L. Bhalla, Mohan B. Singh, Paul A. Knight, Marianne van Hage, John Donnie A. Ramos, Rudolf Valenta

      
  • ·An algorithm for treating chronic urticaria with omalizumab: Dose interval should be individualized

    Pagina :914

    P?nar Uysal, Esben Eller, Charlotte G. Mortz, Carsten Bindslev-Jensen

     
  • ·Characterization of factors associated with systemic corticosteroid use in severe asthma: Data from the Severe Asthma Research Program

    Pagina :915-918

    Kenneth Wysocki, Seo Young Park, Eugene Bleecker, William Busse, Mario Castro, Kian Fan Chung, Benjamin Gaston, Serpil Erzurum, Elliot Israel, W. Gerald Teague, Charity G. Moore, Sally Wenzel

    
  • ·Microarrayed dog, cat, and horse allergens show weak correlation between allergen-specific IgE and IgG responses^?

    Pagina :918

    Mirela Curin, Ines Swoboda, Eva Wollmann, Christian Lupinek, Susanne Spitzauer, Marianne van Hage, Rudolf Valenta

     
  • ·Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: A 12-month follow-up analysis

    Pagina :921-923

    Pranabashis Haldar, Christopher E. Brightling, Amisha Singapuri, Beverley Hargadon, Sumit Gupta, William Monteiro, Peter Bradding, Ruth H. Green, Andrew J. Wardlaw, Hector Ortega, Ian D. Pavord

      
  • ·Ash pollen immunoproteomics: Identification, immunologic characterization, and sequencing of 6 new allergens

    Pagina :923

    Salvador Mas, María Torres, María Garrido-Arandia, Guillermo Salamanca, Lourdes Castro, Patricia Barral, Ashok Purohit, Gabrielle Pauli, Rosalía Rodríguez, Eva Batanero, Rodrigo Barderas, Mayte Villalba

     
  • ·The expression of cannabinoid receptor 1 is significantly increased in atopic patients

    Pagina :926

    Mar Martín-Fontecha, Thomas Eiwegger, Tuomas Jartti, Ainoa Rueda-Zubiaurre, Kerstin Tiringer, Jefim Stepanow, Tuomo Puhakka, Beate Rückert, Silvia Ortega-Gutiérrez, María L. López-Rodríguez, Mübeccel Akdis, Cezmi A. Akdis, Oscar Palomares

     

• Correspondence

  • ·Intralymphatic immunotherapy: Time interval between injections is essential

    Pagina :930-931

    Thomas M. Kündig, Pål Johansen, Martin F. Bachmann, Lars O. Cardell, Gabriela Senti

    
  • ·Reply

    Pagina :931-932

    Hans-Jørgen Malling, Marianne Witten, Lars K. Poulsen

    
  • ·Idiopathic, asymptomatic, and durable blood hypereosinophilia—still many unknowns

    Pagina :932-933

    Grzegorz Helbig, S?awomira Kyrcz-Krzemie?

    
  • ·Reply

    Pagina :933

    Amy D. Klion

    
  • ·Serum levels of bone cytokines in indolent systemic mastocytosis associated with osteopenia or osteoporosis

    Pagina :933-935

    Maurizio Rossini, Silvano Adami, Roberta Zanotti, Ombretta Viapiana, Luca Idolazzi, Marta Biondan, Davide Gatti

     
  • ·Reply

    Pagina :935-936

    Anja Rabenhorst, Karin Hartmann

     
  • ·Why are direct comparisons of subcutaneous and sublingual immunotherapy so rare?

    Pagina :936

    Franco Frati, Ilaria Dell’Albani, Cristoforo Incorvaia

    

• Maintenance of Certification clinical management series

  • ·Use of omalizumab to improve desensitization safety in allergen immunotherapy

    Pagina :937

    Désirée Larenas-Linnemann, Ulrich Wahn, Matthias Kopp

    Mappa Mappa
  • ·In lasting tribute: Burton Zweiman, June 7, 1931–December 24, 2013

    Pagina :938-939

    Arnold I. Levinson, Andrea J. Apter