Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :3A

    
• • ·Table of Contents

    Pagina :6A

    
• • ·Editorial Board

    Pagina :22A

    

• Reader services

  • ·Information for Readers

    Pagina :23A

    
  • ·News & Notes

    Pagina :24A

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  • ·CME Activities Calendar

    Pagina :27A

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :1-2

    Marc E. Rothenberg, Jean Bousquet, Patricia C. Fulkerson

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• Reviews and feature articles

  • ·Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

    Pagina :3-13

    Thomas X. Lu, Marc E. Rothenberg

    Riassunto Riassunto Mappa Mappa  
  • ·Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

    Pagina :14

    
  • ·MicroRNAs: Essential players in the regulation of inflammation

    Pagina :15-26

    Ana Rebane, Cezmi A. Akdis

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  • ·The role of lectins in allergic sensitization and allergic disease

    Pagina :27-36

    Fabián Salazar, Herb F. Sewell, Farouk Shakib, Amir M. Ghaemmaghami

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• The Editors' choice

  • ·The Editors' Choice

    Pagina :37-38

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

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• Asthma and lower airway disease

  • ·Maternal microchimerism protects against the development of asthma

    Pagina :39

    Emma E. Thompson, Rachel A. Myers, Gaixin Du, Tessa M. Aydelotte, Christopher J. Tisler, Debra A. Stern, Michael D. Evans, Penelope E. Graves, Daniel J. Jackson, Fernando D. Martinez, James E. Gern, Anne L. Wright, Robert F. Lemanske, Carole Ober

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  • ·Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone

    Pagina :45

    Gene Colice, Richard J. Martin, Elliot Israel, Nicolas Roche, Neil Barnes, Anne Burden, Peter Polos, Paul Dorinsky, Elizabeth V. Hillyer, Amanda J. Lee, Alison Chisholm, Julie von Ziegenweidt, Francesca Barion, David Price

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  • ·The Pediatric Asthma Control and Communication Instrument asthma questionnaire: For use in diverse children of all ages

    Pagina :55

    Sande O. Okelo, Michelle N. Eakin, Cecilia M. Patino, Alvin P. Teodoro, Andrew L. Bilderback, Darcy A. Thompson, Antonio Loiaza-Martinez, Cynthia S. Rand, Shannon Thyne, Gregory B. Diette, Kristin A. Riekert

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  • ·Comparative outcomes of leukotriene receptor antagonists and long-acting ?-agonists as add-on therapy in asthmatic patients: A population-based study

    Pagina :63-69

    Mohsen Sadatsafavi, Larry Lynd, Carlo Marra, Pierrick Bedouch, Mark FitzGerald

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  • ·Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects

    Pagina :72

    Annette T. Hastie, Wendy C. Moore, Huashi Li, Brian M. Rector, Victor E. Ortega, Rodolfo M. Pascual, Stephen P. Peters, Deborah A. Meyers, Eugene R. Bleecker, National Heart, Lung, and Blood Institute's Severe Asthma Research Program

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  • ·Asthma in the real world

    Pagina :70-71

    Paul M. O'Byrne

    
  • ·What is an “eosinophilic phenotype” of asthma?

    Pagina :81-83

    Parameswaran Nair

     

• Rhinitis, sinusitis, and upper airway disease

  • ·A novel allergen-adjuvant conjugate suitable for specific immunotherapy of respiratory allergy

    Pagina :84

    Lucia Filì, Alessandra Vultaggio, Elisa Cardilicchia, Cinzia Manuelli, Andrea Casini, Francesca Nencini, Laura Maggi, Sara Pratesi, Giulia Petroni, Francesca Boscaro, Antonio Guarna, Ernesto G. Occhiato, Sergio Romagnani, Enrico Maggi, Paola Parronchi

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  • ·Grading local side effects of sublingual immunotherapy for respiratory allergy: Speaking the same language

    Pagina :93-98

    Giovanni Passalacqua, Carlos E. Baena-Cagnani, Jean Bousquet, Giorgio Walter Canonica, Thomas B. Casale, Linda Cox, Stephen R. Durham, Desiréé Larenas-Linnemann, Dennis Ledford, Ruby Pawankar, Paul Potter, Nelson Rosario, Dana Wallace, Richard F. Lockey

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  • ·Sublingual immunotherapy in southern Africa: Lessons learned

    Pagina :99-100

    Paul Potter

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• Atopic dermatitis and skin disease

  • ·Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy

    Pagina :101-109

    Allen Kaplan, Dennis Ledford, Mark Ashby, Janice Canvin, James L. Zazzali, Edward Conner, Joachim Veith, Nikhil Kamath, Petra Staubach, Thilo Jakob, Robert G. Stirling, Piotr Kuna, William Berger, Marcus Maurer, Karin Rosén

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  • ·Efficacy of allergen-specific immunotherapy for atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials

    Pagina :110-117

    Jung Min Bae, Yoon Young Choi, Chang Ook Park, Kee Yang Chung, Kwang Hoon Lee

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• Food, drug, insect sting allergy, and anaphylaxis

  • ·IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3

    Pagina :118

    Merima Bublin, Maria Kostadinova, Christian Radauer, Christine Hafner, Zsolt Szépfalusi, Eva-Maria Varga, Soheila J. Maleki, Karin Hoffmann-Sommergruber, Heimo Breiteneder

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  • ·Higher mast cell load decreases the risk of Hymenoptera venom–induced anaphylaxis in patients with mastocytosis

    Pagina :125-130

    Bjorn van Anrooij, Eveline van der Veer, Jan G.R. de Monchy, Sicco van der Heide, Johanna C. Kluin-Nelemans, Pieter C. van Voorst Vader, Jasper J. van Doormaal, Joanne N.G. Oude Elberink

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  • ·High incidence of heparin-induced allergic delayed-type hypersensitivity reactions in pregnancy

    Pagina :131-139

    Marc Schindewolf, Corinna Gobst, Hartmut Kroll, Andreas Recke, Frank Louwen, Manfred Wolter, Roland Kaufmann, Wolf-Henning Boehncke, Edelgard Lindhoff-Last, Ralf J. Ludwig

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• Immune deficiencies, infection, and systemic immune disorders

  • ·Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: Results of the first 2 years

    Pagina :140

    Antonia Kwan, Joseph A. Church, Morton J. Cowan, Rajni Agarwal, Neena Kapoor, Donald B. Kohn, David B. Lewis, Sean A. McGhee, Theodore B. Moore, E. Richard Stiehm, Matthew Porteus, Constantino P. Aznar, Robert Currier, Fred Lorey, Jennifer M. Puck

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  • ·A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency

    Pagina :151-158

    Haifa H. Jabara, Toshiro Ohsumi, Janet Chou, Michel J. Massaad, Halli Benson, Andre Megarbane, Eliane Chouery, Raymond Mikhael, Oliver Gorka, Andreas Gewies, Pierre Portales, Toshinori Nakayama, Hiroyuki Hosokawa, Patrick Revy, Henry Herrod, Francoise Le Deist, Gerard Lefranc, Jürgen Ruland, Raif S. Geha

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy and clinical immunology

  • ·Surface availability of beta-glucans is critical determinant of host immune response to Cladosporium cladosporioides

    Pagina :159

    Rachael A. Mintz-Cole, Eric B. Brandt, Stacey A. Bass, Aaron M. Gibson, Tiina Reponen, Gurjit K. Khurana Hershey

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  • ·Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

    Pagina :170

    Krzysztof Bryniarski, Wlodzimierz Ptak, Asha Jayakumar, Kerstin Püllmann, Michael J. Caplan, Arthit Chairoungdua, Jun Lu, Brian D. Adams, Emilia Sikora, Katarzyna Nazimek, Susanna Marquez, Steven H. Kleinstein, Panjamaporn Sangwung, Yasuko Iwakiri, Eric Delgato, Frank Redegeld, Bart R. Blokhuis, Jacek Wojcikowski, Anna Wladyslawa Daniel, Tom Groot Kormelink, Philip W. Askenase

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  • ·Cannabinoid receptor 1 controls human mucosal-type mast cell degranulation and maturation in situ

    Pagina :182

    Koji Sugawara, Nóra Zákány, Torsten Hundt, Vladimir Emelianov, Daisuke Tsuruta, Christian Schäfer, Jennifer E. Kloepper, Tamás Bíró, Ralf Paus

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  • ·Histamine receptor 2 modifies dendritic cell responses to microbial ligands

    Pagina :194

    Remo Frei, Ruth Ferstl, Patrycja Konieczna, Mario Ziegler, Tunde Simon, Tulia Mateus Rugeles, Susanne Mailand, Takeshi Watanabe, Roger Lauener, Cezmi A. Akdis, Liam O'Mahony

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  • ·Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates T_H2 cytokine production

    Pagina :205-213

    Taylor A. Doherty, Naseem Khorram, Sean Lund, Amit Kumar Mehta, Michael Croft, David H. Broide

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  • ·Activation of group 2 innate lymphoid cells: A new role for cysteinyl leukotrienes

    Pagina :214-216

    Nora A. Barrett, Joshua A. Boyce

    
  • ·Correction

    Pagina :216

    

• Letters to the Editor

  • ·Differential expression of microRNAs in exhaled breath condensates of patients with asthma, patients with chronic obstructive pulmonary disease, and healthy adults

    Pagina :217

    Mark Pinkerton, Vernon Chinchilli, Erin Banta, Timothy Craig, Avery August, Rebecca Bascom, Margherita Cantorna, Eric Harvill, Faoud T. Ishmael

     
  • ·Exosome-enclosed microRNAs in exhaled breath hold potential for biomarker discovery in patients with pulmonary diseases

    Pagina :219

    Anirban Sinha, Amit Kumar Yadav, Samarpana Chakraborty, S.K. Kabra, R. Lodha, Manish Kumar, Ankur Kulshreshtha, Tavpritesh Sethi, Rajesh Pandey, Gaurav Malik, Saurabh Laddha, Arijit Mukhopadhyay, Debasis Dash, Balaram Ghosh, Anurag Agrawal

     
  • ·Severe phenotype of severe combined immunodeficiency caused by adenosine deaminase deficiency in a patient with a homozygous mutation due to uniparental disomy

    Pagina :222-223

    Joyce Geelen, Rolph Pfundt, Judith Meijer, Frans W. Verheijen, Andre B.P. van Kuilenburg, Adilia Warris, Carlo Marcelis

     
  • ·Common variable immunodeficiency as the initial presentation of dyskeratosis congenita

    Pagina :223-226

    Eric J. Allenspach, Cristian Bellodi, David Jeong, Noam Kopmar, Tomoka Nakamura, Hans D. Ochs, Davide Ruggero, Suzanne Skoda-Smith, Akiko Shimamura, Troy R. Torgerson

     
  • ·Cord blood transplantation combined with rituximab for Wiskott-Aldrich syndrome with autoimmune thrombotic thrombocytopenic purpura

    Pagina :226-227

    Hidemi Toyoda, Eiichi Azuma, Yukako Kawasaki, Tadashi Iwasa, Hiroyuki Ohashi, Shoichiro Otsuki, Shotaro Iwamoto, Masahiro Hirayama, Naomi Itoh-Habe, Hideo Wada, Mineo Kondo, Yoshitaka Keida, Tsuyoshi Ito, Yoshihiro Komada

     
  • ·Risk of childhood asthma following infant bronchiolitis during the respiratory syncytial virus season

    Pagina :227-229

    Kristina M. James, Tebeb Gebretsadik, Gabriel J. Escobar, Pingsheng Wu, Kecia N. Carroll, Sherian Xu Li, Eileen M. Walsh, Edward F. Mitchel, Chantel Sloan, Tina V. Hartert

     
  • ·Serum levels of Clara cell secretory protein, asthma, and lung function in the adult general population

    Pagina :230

    Marta Rava, Lluisa Tares, Iris Lavi, Esther Barreiro, Jan-Paul Zock, Anna Ferrer, Nerea Muniozguren, Rachel Nadif, Lucia Cazzoletti, Francine Kauffmann, Josep M. Anto, Stefano Guerra

     
  • ·Serum IL-31 levels are increased in a subset of patients with mastocytosis and correlate with disease severity in adult patients

    Pagina :232

    Karin Hartmann, Nicola Wagner, Anja Rabenhorst, Liselotte Pflanz, Silke Leja, Anja Förster, Manuela Gehring, Alexander Kapp, Ulrike Raap

     
  • ·False-positive penicillin immunoassay: An unnoticed common problem

    Pagina :235-237

    S.G.O. Johansson, Justus Adédoyin, Marianne van Hage, Reidar Grönneberg, Anna Nopp

    
  • ·High-dose cyclophosphamide used to treat aplastic anemia in a patient with respiratory and food allergies has a prolonged effect on serum IgE levels

    Pagina :237-239

    Marisha L. Cook, Robert A. Brodsky, Robert Hamilton, Robert A. Wood, Bruce S. Bochner

    
  • ·Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status

    Pagina :239

    Yuka Asai, Celia Greenwood, Peter R. Hull, Reza Alizadehfar, Moshe Ben-Shoshan, Sara J. Brown, Linda Campbell, Deborah L. Michel, Johanne Bussières, François Rousseau, T. Mary Fujiwara, Kenneth Morgan, Alan D. Irvine, W.H. Irwin McLean, Ann Clarke

    
  • ·House dust mite models: Will they translate clinically as a superior model of asthma?

    Pagina :242-244

    Jonathan E. Phillips, Ruoqi Peng, Paul Harris, Lisa Burns, Lorena Renteria, Lennart K.A. Lundblad, Jay S. Fine, Carla M.T. Bauer, Christopher S. Stevenson

     
  • ·On sharing unique reagents

    Pagina :245-246

    Fred D. Finkelman

    

• Correspondence

  • ·Should clinicians use omalizumab for the treatment of nasal polyps?

    Pagina :247

    Robert M. Naclerio, Fuad M. Baroody, Jayant M. Pinto

    
  • ·Reply

    Pagina :247-248

    Lien Calus, Peter Hellings, Guy Brusselle, Claus Bachert, Philippe Gevaert

    
  • ·Design of the EpiPen Auto-Injector

    Pagina :248

    Luis M. Salmun, Paul F. Cavanaugh

    
  • ·Reply

    Pagina :248-249

    A. Wesley Burks, Stacie M. Jones

    

• Maintenance of Certification clinical management series

  • ·Role of diet and gut microbiota in management of inflammatory bowel disease in an Asian migrant

    Pagina :250

    Purna C. Kashyap, Christopher S. Reigstad, Edward V. Loftus

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