Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·A Brief Overview of This Month’s JACI

    Pagina :3A

    
• • ·Table of Contents

    Pagina :7A

    
• • ·Editorial Board

    Pagina :24A

    

• Reader services

  • ·Information for Readers

    Pagina :26A

    
  • ·News & Notes

    Pagina :28A

    Mappa Mappa  
  • ·CME Activities Calendar

    Pagina :33A

    Mappa Mappa

• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :423-424

    Marc E. Rothenberg, Jean Bousquet

    Mappa Mappa  

• Reviews and feature articles

  • ·Application of genetic/genomic approaches to allergic disorders

    Pagina :425-436

    Tesfaye M. Baye, Lisa J. Martin, Gurjit K. Khurana Hershey

    Riassunto Riassunto Mappa Mappa  
  • ·Application of genetic/genomic approaches to allergic disorders

    Pagina :437-438

    
  • ·Genetics of asthma and allergy: What have we learned?

    Pagina :439-446

    Deborah A. Meyers

    Riassunto Riassunto Mappa Mappa  
  • ·Genetics of asthma and allergy: What have we learned?

    Pagina :447-448

    
  • ·The US Food and Drug Administration and long-acting β₂-agonists: The importance of striking the right balance between risks and benefits of therapy?

    Pagina :449-452

    Robert F. Lemanske, William W. Busse

    
  • ·Environmental epigenetics of asthma: An update

    Pagina :453-465

    Shuk-Mei Ho

    Riassunto Riassunto Mappa Mappa  
  • ·Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision

    Pagina :466-476

    Jan L. Brożek, Jean Bousquet, Carlos E. Baena-Cagnani, Sergio Bonini, G. Walter Canonica, Thomas B. Casale, Roy Gerth van Wijk, Ken Ohta, Torsten Zuberbier, Holger J. Schünemann

    Riassunto Riassunto Mappa Mappa  
  • ·The diagnosis and management of anaphylaxis practice parameter: 2010 Update

    Pagina :477

    Phillip Lieberman, Richard A. Nicklas, John Oppenheimer, Stephen F. Kemp, David M. Lang, David I. Bernstein, Jonathan A. Bernstein, A. Wesley Burks, Anna M. Feldweg, Jordan N. Fink, Paul A. Greenberger, David B.K. Golden, John M. James, Stephen F. Kemp, Dennis K. Ledford, Phillip Lieberman, Albert L. Sheffer, David I. Bernstein, Joann Blessing-Moore, Linda Cox, David A. Khan, David Lang, Richard A. Nicklas, John Oppenheimer, Jay M. Portnoy, Christopher Randolph, Diane E. Schuller, Sheldon L. Spector, Stephen Tilles, Dana Wallace

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors’ Choice

    Pagina :481-482

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

    Mappa Mappa  

• Asthma and lower airway disease

  • ·Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life

    Pagina :483

    Weiguo Yao, Florencia M. Barbé-Tuana, Conrado J. Llapur, Marcus H. Jones, Christina Tiller, Risa Kimmel, Jeffrey Kisling, Evelyn T. Nguyen, James Nguyen, Zhangsheng Yu, Mark H. Kaplan, Robert S. Tepper

    Riassunto Riassunto Mappa Mappa  
  • ·In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma

    Pagina :491-497

    Robyn T. Cohen, Benjamin A. Raby, Kristel Van Steen, Anne L. Fuhlbrigge, Juan C. Celedón, Bernard A. Rosner, Robert C. Strunk, Robert S. Zeiger, Scott T. Weiss, Childhood Asthma Management Program Research Group

    Riassunto Riassunto Mappa Mappa  
  • ·Gender differences in asthma development and remission during transition through puberty: The TRacking Adolescents' Individual Lives Survey (TRAILS) study

    Pagina :498

    Nienke M. Vink, Dirkje S. Postma, Jan P. Schouten, Judith G.M. Rosmalen, H. Marike Boezen

    Riassunto Riassunto Mappa Mappa  
  • ·Randomized controlled trial of adherence with single or combination inhaled corticosteroid/long-acting β-agonist inhaler therapy in asthma

    Pagina :505-510

    Kyle Perrin, Mathew Williams, Meme Wijesinghe, Kate James, Mark Weatherall, Richard Beasley

    Riassunto Riassunto Mappa Mappa  
  • ·Prescribing practices and asthma control with hydrofluoroalkane-beclomethasone and fluticasone: A real-world observational study

    Pagina :511

    David Price, Richard J. Martin, Neil Barnes, Paul Dorinsky, Elliot Israel, Nicolas Roche, Alison Chisholm, Elizabeth V. Hillyer, Linda Kemp, Amanda J. Lee, Julie von Ziegenweidt, Gene Colice

    Riassunto Riassunto Mappa Mappa  
  • ·Symptom-pattern phenotype and pulmonary function in preschool wheezers

    Pagina :519

    Samatha Sonnappa, Cristina M. Bastardo, Angela Wade, Sejal Saglani, Sheila A. McKenzie, Andrew Bush, Paul Aurora

    Riassunto Riassunto Mappa Mappa  
  • ·Forced expiratory flow between 25% and 75% of vital capacity and FEV₁/forced vital capacity ratio in relation to clinical and physiological parameters in asthmatic children with normal FEV₁ values

    Pagina :527

    Michael R. Simon, Vernon M. Chinchilli, Brenda R. Phillips, Christine A. Sorkness, Robert F. Lemanske, Stanley J. Szefler, Lynn Taussig, Leonard B. Bacharier, Wayne Morgan, Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute

    Riassunto Riassunto Mappa Mappa  
  • ·Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone

    Pagina :537

    Michelle L. Hernandez, John C. Lay, Bradford Harris, Charles R. Esther, W. June Brickey, Philip A. Bromberg, David Diaz-Sanchez, Robert B. Devlin, Steven R. Kleeberger, Neil E. Alexis, David B. Peden

    Riassunto Riassunto Mappa Mappa  
  • ·Urinary leukotriene E₄/exhaled nitric oxide ratio and montelukast response in childhood asthma

    Pagina :545

    Nathan Rabinovitch, Nora J. Graber, Vernon M. Chinchilli, Christine A. Sorkness, Robert S. Zeiger, Robert C. Strunk, Leonard B. Bacharier, Fernando D. Martinez, Stanley J. Szefler, Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute ∗

    Riassunto Riassunto Mappa Mappa
  • ·Exposure to community violence is associated with asthma hospitalizations and emergency department visits

    Pagina :552-557

    Andrea J. Apter, Laura A. Garcia, Rhonda C. Boyd, Xingmei Wang, Daniel K. Bogen, Thomas Ten Have

    Riassunto Riassunto Mappa Mappa
  • ·Multitrigger versus episodic wheeze in toddlers: New phenotypes or severity markers?

    Pagina :489-490

    Luis Garcia-Marcos, Fernando D. Martinez

    
  • ·Resurrection men and the FEF_25-75

    Pagina :535-536

    E.R. McFadden

    

• Rhinitis, sinusitis, and upper airway disease

  • ·Efficacy of sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A systematic review and meta-analysis

    Pagina :558-566

    Danilo Di Bona, Antonella Plaia, Valeria Scafidi, Maria Stefania Leto-Barone, Gabriele Di Lorenzo

    Riassunto Riassunto Mappa Mappa  
  • ·Children with allergic and nonallergic rhinitis have a similar risk of asthma

    Pagina :567

    Bo Lund Krogsgaard Chawes, Klaus Bønnelykke, Eskil Kreiner-Møller, Hans Bisgaard

    Riassunto Riassunto Mappa Mappa  

• Atopic dermatitis and skin disease

  • ·Raman profiles of the stratum corneum define 3 filaggrin genotype–determined atopic dermatitis endophenotypes

    Pagina :574

    Gráinne M. O’Regan, Patrick M.J.H. Kemperman, Aileen Sandilands, Huijia Chen, Linda E. Campbell, Karin Kroboth, Rosemarie Watson, Marion Rowland, Gerwin J. Puppels, W.H. Irwin McLean, Peter J. Caspers, Alan D. Irvine

    Riassunto Riassunto Mappa Mappa  
  • ·MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated antigen 4

    Pagina :581

    Enikö Sonkoly, Peter Janson, Marja-Leena Majuri, Terhi Savinko, Nanna Fyhrquist, Liv Eidsmo, Ning Xu, Florian Meisgen, Tianling Wei, Maria Bradley, Jan Stenvang, Sakari Kauppinen, Harri Alenius, Antti Lauerma, Bernhard Homey, Ola Winqvist, Mona Ståhle, Andor Pivarcsi

    Riassunto Riassunto Mappa Mappa  
  • ·Prediction of the incidence, recurrence, and persistence of atopic dermatitis in adolescence: A prospective cohort study

    Pagina :590

    Astrid S. Peters, Jessica Kellberger, Christian Vogelberg, Holger Dressel, Doris Windstetter, Gudrun Weinmayr, Jon Genuneit, Dennis Nowak, Erika von Mutius, Katja Radon

    Riassunto Riassunto Mappa Mappa  

• Food, drug, insect sting allergy, and anaphylaxis

  • ·Identification of IgE sequential epitopes of lentil (Len c 1) by means of peptide microarray immunoassay

    Pagina :596

    Andrea Vereda, Doerthe A. Andreae, Jing Lin, Wayne G. Shreffler, Maria Dolores Ibañez, Javier Cuesta-Herranz, Ludmilla Bardina, Hugh A. Sampson

    Riassunto Riassunto Mappa Mappa  

• Immune deficiencies, infection, and systemic immune disorders

  • ·Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: Entering a new century, do we do better?

    Pagina :602

    Andrew R. Gennery, Mary A. Slatter, Laure Grandin, Pierre Taupin, Andrew J. Cant, Paul Veys, Persis J. Amrolia, H. Bobby Gaspar, E. Graham Davies, Wilhelm Friedrich, Manfred Hoenig, Luigi D. Notarangelo, Evelina Mazzolari, Fulvio Porta, Robbert G.M. Bredius, Arjen C. Lankester, Nico M. Wulffraat, Reinhard Seger, Tayfun Güngör, Anders Fasth, Petr Sedlacek, Benedicte Neven, Stephane Blanche, Alain Fischer, Marina Cavazzana-Calvo, Paul Landais, Members of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency

    Riassunto Riassunto Mappa Mappa  
  • ·Diagnostic approach to the hyper-IgE syndromes: Immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis

    Pagina :611

    Lena F. Schimke, Julie Sawalle-Belohradsky, Joachim Roesler, Andreas Wollenberg, Anita Rack, Michael Borte, Nikolaus Rieber, Reinhold Cremer, Eberhart Maaß, Roland Dopfer, Janine Reichenbach, Volker Wahn, Manfred Hoenig, Annette F. Jansson, Angela Roesen-Wolff, Bianca Schaub, Reinhard Seger, Harry R. Hill, Hans D. Ochs, Troy R. Torgerson, Bernd H. Belohradsky, Ellen D. Renner

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy and clinical immunology

  • ·Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients

    Pagina :618

    Ying Jin, Donglei Hu, Edward L. Peterson, Celeste Eng, Albert M. Levin, Karen Wells, Kenneth Beckman, Rajesh Kumar, Max A. Seibold, Gloria Karungi, Amanda Zoratti, John Gaggin, Janis Campbell, Joshua Galanter, Rocío Chapela, José R. Rodríguez-Santana, H. Geoffrey Watson, Kelley Meade, Michael LeNoir, William Rodríguez-Cintrón, Pedro C. Avila, David E. Lanfear, Esteban G. Burchard, L. Keoki Williams

    Riassunto Riassunto Mappa Mappa  
  • ·Genetic influence on the age at onset of asthma: A twin study

    Pagina :626-630

    Simon Francis Thomsen, David Lorenzo Duffy, Kirsten Ohm Kyvik, Vibeke Backer

    Riassunto Riassunto Mappa Mappa  
  • ·Analyses of shared genetic factors between asthma and obesity in children

    Pagina :631

    Erik Melén, Blanca E. Himes, John M. Brehm, Nadia Boutaoui, Barbara J. Klanderman, Jody S. Sylvia, Jessica Lasky-Su

    Riassunto Riassunto Mappa Mappa
  • ·Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-β1 and IL-10–producing properties

    Pagina :638

    Jean-Pierre Allam, Peter A. Würtzen, Markus Reinartz, Jochen Winter, Susanne Vrtala, Kuan-Wei Chen, Rudolf Valenta, Matthias Wenghoefer, Thorsten Appel, Eva Gros, Bernd Niederhagen, Thomas Bieber, Kaare Lund, Natalija Novak

    Riassunto Riassunto Mappa Mappa  
  • ·Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization

    Pagina :648

    Marcus Peters, Marion Kauth, Olaf Scherner, Kirsten Gehlhar, Imke Steffen, Pia Wentker, Erika von Mutius, Otto Holst, Albrecht Bufe

    Riassunto Riassunto Mappa Mappa  
  • ·Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood

    Pagina :657-663

    Klaus Bønnelykke, Christian Bressen Pipper, Hans Bisgaard

    Riassunto Riassunto Mappa Mappa  
  • ·Immune mechanisms of sublingual immunotherapy: Are oral Langerhans cells the masters of tolerance?

    Pagina :646-647

    Mark Larché

    

• Letters to the Editor

  • ·Successful use of omalizumab for prevention of fire ant anaphylaxis

    Pagina :664-665

    Hana M. Tartibi, Amee R. Majmundar, David A. Khan

    
  • ·Effective treatment of therapy-resistant chronic spontaneous urticaria with omalizumab

    Pagina :665-666

    Markus Magerl, Petra Staubach, Sabine Altrichter, Elena Ardelean, Karoline Krause, Martin Metz, Karsten Weller, Marcus Maurer

     
  • ·Uncontrolled allergic rhinitis during treatment and its impact on quality of life: A cluster randomized trial

    Pagina :666

    Philippe J. Bousquet, Claus Bachert, Giorgo W. Canonica, Thomas B. Casale, Joaquim Mullol, Jean Michel Klossek, Torsten Zuberbier, Jean Bousquet

     
  • ·How adherent to sublingual immunotherapy prescriptions are patients? The manufacturers’ viewpoint

    Pagina :668-669

    Gianenrico Senna, Carlo Lombardi, Giorgio Walter Canonica, Giovanni Passalacqua

     
  • ·Wheezing in preschool children is associated with increased levels of cytokines/chemokines in exhaled breath condensate

    Pagina :669-671

    Kim D.G. van de Kant, Ester M.M. Klaassen, Quirijn Jöbsis, Karlijn Koers, Ger T. Rijkers, Chris P. van der Grinten, Onno C.P. van Schayck, Valéria Lima Passos, Edward Dompeling

     
  • ·Impaired T_H2 response in patients with Vav1-deficient common variable immunodeficiency with T-cell defects

    Pagina :671-675

    Nagaja Capitani, Amedeo Amedei, Silvia Rossi Paccani, Andrea Matucci, Alessandra Vultaggio, Gianfranco Del Prete, Cosima T. Baldari, Mario M. D’Elios

     
  • ·Safety of small-particle inhaled corticosteroids in infants

    Pagina :676

    H. William Kelly

    
  • ·Reply

    Pagina :676-677

    Israel Amirav, Michael Newhouse

    
  • ·Are free light chain immunoglobulins related to nasal local allergic rhinitis?

    Pagina :677

    Carmen Rondón, Gabriela Canto, Javier Fernández, Miguel Blanca

    
  • ·Reply

    Pagina :677-678

    Desmond G. Powe, Tom Groot Kormelink, Melanie Sisson, Bart J. Blokhuis, Matthias F. Kramer, Nicholas S. Jones, Frank A. Redegeld