Sommario

• Editorial

  • ·The Future is Now: Advancing Blood-Based Markers

    Pagina :563-564

    Maria C. Carrillo, R.M. Edelmayer, H.M. Snyder

    
  • ·Blood-Based Biomarkers for Alzheimer’s Disease: Are We There Yet?

    Pagina :565-566

    Pierre Tariot

    
  • ·What Are the Remaining Challenges before Blood-Based Biomarkers for Alzheimer’s Disease Can Be Used in Clinical Practice?

    Pagina :567-568

    Tobias Bittner

    

• CTAD Task Force Paper

  • ·Blood Biomarkers from Research Use to Clinical Practice: What Must Be Done? A Report from the EU/US CTAD Task Force

    Pagina :569-579

    Davide Angioni, J. Delrieu, O. Hansson, H. Fillit, P. Aisen, J. Cummings, J.R. Sims, J.B. Braunstein, M. Sabbagh, T. Bittner, M. Pontecorvo, S. Bozeat, J.L. Dage, E. Largent, S. Mattke, O. Correa, L.M. Gutierrez Robledo, V. Baldivieso, D.R. Willis, A. Atri, R.J. Bateman, P.-J. Ousset, B. Vellas, M. Weiner, EU/US/CTAD Task Force

    Riassunto Riassunto Mappa Mappa

• Review

  • ·The role of Aβ in Alzheimer’s Disease as an Evolutionary Outcome of Optimized Innate Immune Defense

    Pagina :580-588

    Marc Tatar

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  • ·A Hierarchical Bayesian Latent Class Model for the Diagnostic Performance of Mini-Mental State Examination and Montreal Cognitive Assessment in Screening Mild Cognitive Impairment Due to Alzheimer’s Disease

    Pagina :589-600

    Xiaonan Wang, Fengjie Li, H. Zhu, Z. Jiang, G. Niu, Qi Gao

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  • ·Effectiveness of Physical Exercise on Alzheimer’s disease. A Systematic Review

    Pagina :601-616

    R. Cámara-Calmaestra, A. Martínez-Amat, Agustín Aibar-Almazán, F. Hita-Contreras, N. de Miguel Hernando, A. Achalandabaso-Ochoa

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• Original Research

  • ·Amyloid-Related Imaging Abnormalities and Other MRI Findings in a Cognitively Unimpaired Population With and Without Cerebral Amyloid

    Pagina :617-624

    Roy Yaari, K.C. Holdridge, J. Choi, M.C. Donohue, K. Kantarci, C.R. Jack, S.M. Zuk, J.R. Sims, K.A. Johnson, P.S. Aisen, R.A. Sperling, A4 Study Team

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  • ·Adjudicating Mild Cognitive Impairment Due to Alzheimer’s Disease as a Novel Endpoint Event in the TOMMORROW Prevention Clinical Trial

    Pagina :625-634

    Lon S. Schneider, D.A. Bennett, M.R. Farlow, E.R. Peskind, M.A. Raskind, M. Sano, Y. Stern, S. Haneline, K.A. Welsh-Bohmer, J. O’Neil, R. Walter, S. Maresca, M. Culp, R. Alexander, A.M. Saunders, D.K. Burns, C. Chiang

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  • ·Safety, Tolerability and Pharmacokinetics of Icapamespib, a Selective Epichaperome Inhibitor, in Healthy Adults

    Pagina :635-645

    M.H. Silverman, S. Duggan, Geraldine Bardelli, B. Sadler, C. Key, M. Medlock, L. Reynolds, B. Wallner

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  • ·Intervention for Cognitive Reserve Enhancement in Delaying the Onset of Alzheimer’s Symptomatic Expression (INCREASE) Study: Results from a Randomized Controlled Study of Medication Therapy Management Targeting a Delay in Prodromal Dementia Symptom Progression

    Pagina :646-654

    Daniela C. Moga, E.L. Abner, F.A. Schmitt, L. Eckmann, M. Huffmyer, A.I. Martinez, B.F. Beech, R. George, R.H. El Khouli, D. Ali, G.A. Jicha

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  • ·Association of a MIND Diet with Brain Structure and Dementia in a French Population

    Pagina :655-664

    Aline Thomas, S. Lefèvre-Arbogast, C. Féart, A. Foubert-Samier, C. Helmer, G. Catheline, C. Samieri

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  • ·Alzheimer’s Disease Clinical Trial Research Adaptation Following COVID-19 Pandemic Onset: National Sample of Alzheimer’s Clinical Trial Consortium Sites

    Pagina :665-671

    Elizabeth K. Rhodus, P. Aisen, J.D. Grill, D.M. Rentz, R.C. Petersen, R.A. Sperling, S.P. Salloway, D. Pierce, R. Raman

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  • ·Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach

    Pagina :672-678

    A.R. Shaw, J. Perales-Puchalt, T. Moore, P. Weatherspoon, M. Robinson, C.V. Hill, Eric D. Vidoni

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  • ·Delayed Decline of Cognitive Function by Antihypertensive Agents: A Cohort Study Linked with Genotype Data

    Pagina :679-691

    Zohara Sternberg, R. Podolsky, J. Yu, M. Tian, D. Hojnacki, B. Schaller

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  • ·Sex Moderates the Association between Frailty and Mild Behavioral Impairment

    Pagina :692-700

    D.X. Guan, K. Rockwood, E.E. Smith, Zahinoor Ismail

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  • ·Obesity and Brain Health: The Impact of Metabolic Syndrome and Cardiorespiratory Fitness on Cognitive Performances in Middle-Aged Obese Women

    Pagina :701-707

    W. Wichayanrat, S. Boripuntakul, P. Keawtep, P. Worakul, Somporn Sungkarat

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  • ·Age, Sex, Hypertension and HDL-C Alter Serum BACE1 Activity in Cognitively Normal Subjects: Implications for Alzheimer’s Disease

    Pagina :708-714

    C. Cervellati, A. Vergallo, Alessandro Trentini, G. Campo, F. Vieceli Dalla Sega, P. Rizzo, G. Bonaccorsi, V. Rosta, C. Renzini, S. Pacifico, A. Passaro, H. Hampel, G. Zuliani

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  • ·Antihypertensive Agents and Incident Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Observational Studies

    Pagina :715-724

    M. Adesuyan, Y.H. Jani, D. Alsugeir, E.C.L. Cheung, C.S.L. Chui, R. Howard, I.C.K. Wong, Ruth Brauer

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  • ·Association of Preeclampsia with Incident Dementia and Alzheimer’s Disease among Women in the Framingham Offspring Study

    Pagina :725-730

    Kanran Wang, Kaining Guo, Z. Ji, Y. Liu, F. Chen, S. Wu, Q. Zhang, Yizheng Yao, Qin Zhou

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  • ·Sex-Driven Differences in the Effectiveness of Individualized Clinical Management of Alzheimer’s Disease Risk

    Pagina :731-742

    N. Saif, H. Hristov, K. Akiyoshi, K. Niotis, I.E. Ariza, N. Malviya, P. Lee, J. Melendez, G. Sadek, K. Hackett, A. Rahman, J. Meléndez-Cabrero, C.E. Greer, L. Mosconi, R. Krikorian, Richard S. Isaacson

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  • ·Objective and Subjective Measurements of Motor Function: Results from the HELIAD Study

    Pagina :743-751

    F. Kalligerou, G. Paraskevas, I. Zalonis, M.H. Kosmidis, M. Yannakoulia, E. Dardiotis, G. Hadjigeorgiou, P. Sakka, Nikolaos Scarmeas

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  • ·Salivary Alpha-Amylase Activity and Mild Cognitive Impairment among Japanese Older Adults: The Toon Health Study

    Pagina :752-757

    N. Yamane, A. Ikeda, K. Tomooka, I. Saito, K. Maruyama, E. Eguchi, K. Suyama, A. Fujii, T. Shiba, K. Tanaka, A. Kooka, S. Nakamura, M. Kajita, R. Kawamura, Y. Takata, H. Osawa, A. Steptoe, Takeshi Tanigawa

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  • ·Evaluation of the Fiscal Costs and Consequences of Alzheimer’s Disease in Germany: Microsimulation of Patients’ and Caregivers’ Pathways

    Pagina :758-768

    R. Martins, N. Kotsopoulos, B. Michalowsky, P. Pemberton-Ross, M. Urbich, Mark P. Connolly

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  • ·In Vivo Detection of Changes Related to Cortical Columnar Organization and Neuroinflammation Across the AD Continuum

    Pagina :769-779

    Mario Torso, G.R. Ridgway, I. Hardingham, A.J. Schwarz, S.A. Chance, Alzheimer’s Disease Neuroimaging Initiative

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  • ·Oral Tau Aggregation Inhibitor for Alzheimer’s Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate

    Pagina :780-790

    Claude M. Wischik, P. Bentham, S. Gauthier, S. Miller, K. Kook, B.O. Schelter

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  • ·Cognitive Digital Biomarkers from Automated Transcription of Spoken Language

    Pagina :791-800

    N. Tavabi, D. Stück, A. Signorini, C. Karjadi, T. Al Hanai, M. Sandoval, C. Lemke, J. Glass, S. Hardy, M. Lavallee, B. Wasserman, T.F.A. Ang, C.M. Nowak, R. Kainkaryam, L. Foschini, Rhoda Au

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  • ·Everyday Functioning and Entorhinal and Inferior Temporal Tau Burden in Cognitively Normal Older Adults

    Pagina :801-808

    M.A. Dubbelman, J. Sanchez, A.P. Schultz, D.M. Rentz, R.E. Amariglio, S.A.M. Sikkes, R.A. Sperling, K.A. Johnson, Gad A. Marshall, A4 Study team, full listing of team and site personnel available at A4STUDΥ.org

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• Brief Report

  • ·Validation of the Saint Louis University Quality of Life Questionnaire in Older Adults with Alzheimer’s Disease

    Pagina :809-812

    K.Y. Yamashita, E.S. Deol, S.J. Elliott, J.E. Morley, T.K. Malmstrom

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• Letter to the Editor

  • ·Beyond Frailty in Alzheimer’s Disease: Should We Move to the Concept of Intrinsic Capacity?

    Pagina :813-815

    Antoine Garnier-Crussard, V. Dauphinot, A. Zamudio-Rodriguez, P. Krolak-Salmon

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  • ·Genetically Determined Alzheimer’s Disease Is Associated with Increased Risk of Varicose Vein: A Mendelian Randomization Study

    Pagina :816-817

    C. Zheng, Ruijie Zeng