Proximal median (PMNE) and radial (RNE) nerve entrapment syndromes are uncommon. This article provides an evidenced-based treatment guideline for PMNE and RNE based on the available literature. Arriving at an accurate diagnosis must involve an electrodiagnostic (EDx) workup. EDx, including nerve conduction velocity studies and needle electromyography, should corroborate the clinical diagnosis and must be done before consideration of any surgical treatment. Conservative care includes rest, modified activities, splinting at wrist and elbow, physical therapy, antiinflammatory drug therapy, and corticosteroid injections. Conservative care should be required for at least 6 weeks before any operative interventions are considered.