High serum cancer antigen 125 level indicates perforation in acute appendicitis - 30/07/15
, Ahmet Erdoğan, MD, Özgür Akgül, MD, Canbert Çelik, MD, Mesut TezAbstract |
Background |
The diagnosis of acute appendicitis is sometimes challenging, and prompt evaluation is required because of the risk of complications if not treated appropriately.
Aim |
We aimed to evaluate whether cancer antigen 125 (CA-125) has diagnositic accuracy and predictor of the severity in acute appendicitis.
Results |
Sixty patients with acute appendicitis were recruited prospectively in this study between May 2014 and March 2015. Blood samples were obtained to measure CA-125 levels before appendectomy. Of the 57 patients, 10 had perforated or gangrenous appendicitis intraoperatively. The CA-125 levels were significantly higher in patients with perforated or gangrenous appendicitis than patients with uncomplicated appendicitis (49.9 vs 10.5 U/mL, P = .000).
Conclusions |
Cancer antigen 125 levels in patients with highly suspected or confirmed appendicitis could help clinicians determine the severity of the disease.
Il testo completo di questo articolo è disponibile in PDF.Mappa
| ☆ | Prospective study, Ethics Committee at Ankara Numune Training and Research Hospital (Ankara, Turkey) (approval no. 811 at 14.04.2014). |
| ☆☆ | The work has not been published before and is not currently under consideration for publication elsewhere. |
| ★ | The authors have no relevant financial interest in the products or companies described in this article. |
| ★★ | Recently, with the advance of diagnostic imaging studies, nonoperative treatment has gained the popularity for uncomplicated acute appendicitis. As appendectomy has some surgical complications and negative appendectomy risk for suspected but not certain cases, antibiotic treatment for patients with uncomplicated acute appendicitis could be an option. Measurement of cancer antigen 125 levels in patients with suspected acute appendicitis in emergency department will help clinicians consider the severity of the disease. In uncomplicated cases, measuring cancer antigen 125 levels consecutively in the follow-up and observing the increasing pattern will warn the clinicians, as complications will ocur. |
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?