Estrogen Receptor 1 (ESR1) genetic variations in cancer risk: A systematic review and meta-analysis - 05/02/15

Doi : 10.1016/j.clinre.2014.07.016

Huiling Sun ^a,^{^{1
Huiling Sun and Jinjun Hou contributed equally to this work and should be considered as co-first authors.}}, Jinjun Hou ^b,^c,^⁎ , Wenbin Shi ^d, Lei Zhang ^e
^a Department of Life Sciences, Nanjing Normal University, Nanjing 210046, Jiangsu, China
^b Clinical Laboratory, Mother and Child Health Care Hospital of Qixia District, Nanjing, Nanjing 210028, Jiangsu, China
^c Clinical Laboratory, The North Branch of Nanjing Mother and Child Health Care Hospital, Nanjing 210004, Jiangsu, China
^d Clinical Laboratory, Nanjing Traditional Chinese Medical Hospital, Nanjing 210001, Jiangsu, China
^e Department of Orthopaedics, Lanxi People's Hospital, Jinhua, 321100 Zhejiang, China

^⁎Corresponding author. Clinical Laboratory, Mother and Child Health Care Hospital of Qixia District, Nanjing, Nanjing 210028, Jiangsu, China.

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Summary

Background

Emerging published data on the association between single nucleotide polymorphisms (SNPs) in the estrogen receptor 1 (ESR1) gene and cancer susceptibility are inconsistent. This review and meta-analysis is performed to derive a more precise evaluation of this relationship.

Methods

The literature search of PubMed, Embase, Web of Science and CNKI databases was conducted from their inception through June 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association.

Results

Twenty-two literatures were enrolled in this meta-analysis. The results indicated that ESR1 rs1801132 (C>G) was associated with cancer risk in Caucasian populations. However, the results of stratified analysis by cancer type and source of controls indicated that no significant association was found. Furthermore, rs2077647 (A>G) was only associated with an increased risk of hepatocellular carcinoma, but was an adverse effect on cancer risk in Caucasian populations.

Conclusions

This present meta-analysis indicated that rs1801132 (C>G) and rs2077647 (A>G) may be protective factors in Caucasian populations. Meanwhile, rs2077647 (A>G) may be closely related with hepatocellular carcinoma.

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Introduction

Material and methods

Publication selection

Inclusion and exclusion criteria

Data extraction

Statistical methods

Results

Characteristics of studies

Main results

Test of heterogeneity and sensitivity analysis

Publication bias

Discussion

Disclosure of interest

Esportazione

Vol 39 - N° 1

P. 127-135 - Febbraio 2015 Ritorno al numero

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Estrogen Receptor 1 (ESR1) genetic variations in cancer risk: A systematic review and meta-analysis - 05/02/15

Summary

Background

Methods

Results

Conclusions

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