Pathophysiology of Muscle Contractures in Cerebral Palsy - 05/12/14
Riassunto |
Patients with cerebral palsy present with a variety of adaptations to muscle structure and function. These pathophysiologic symptoms include functional deficits such as decreased force production and range of motion, in addition to changes in muscle structure such as decreased muscle belly size, increased sarcomere length, and altered extracellular matrix structure and composition. On a cellular level, patients with cerebral palsy have fewer muscle stem cells, termed satellite cells, and altered gene expression. Understanding the nature of these changes may present opportunities for the development of new muscle treatment therapies.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Cerebral palsy, Skeletal muscle, Extracellular matrix, Sarcomere, Fiber, Gene expression, Pathophysiology
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| Disclosure: Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award numbers AR057393 and R24HD050837. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. |
Vol 26 - N° 1
P. 57-67 - Febbraio 2015 Ritorno al numero
Articolo precedente
- The Importance of Good Nutrition in Children with Cerebral Palsy
- Gina Rempel
- Pediatric Tone Management
- Sathya Vadivelu, Anne Stratton, Wendy Pierce
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