Expression of epithelial cell adhesion molecule associated with elevated ductular reactions in hepatocellar carcinoma - 20/11/14

Doi : 10.1016/j.clinre.2014.04.015

Minhui Xu ^a,^b,^{^{1
These authors contributed equally to this work.}}, Guangyang Qian ^b,^d,^{^{1
These authors contributed equally to this work.}}, Feng Xie ^c,^{^{1
These authors contributed equally to this work.}}, Changying Shi ^c, Long Yan ^c, Lihan Yu ^c, Tao Zheng ^c, Lixin Wei ^b,^⁎, Jiamei Yang ^c,^⁎
^a Department of General Surgery, the Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China
^b Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China
^c Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China
^d Department of Gastrointestinal surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China

^⁎Corresponding author. Tel.: +86 21 25075543; fax: +86 21 25030398.

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Summary

Aim

To evaluate the prognostic significance of the epithelial cell adhesion molecule (EpCAM) expression in HCC, the relationship between EpCAM with ductular reactions and other clinical features.

Methods

From 2001 to 2003, 106 HCC patients who underwent curative resection in Eastern Hepatobiliary Hospital were enrolled. The expression of EpCAM in tumoral tissues and ductular reactions in paired non-tumoral tissues was assessed by immunohistochemistry. EpCAM was evaluated with prognosis, ductular reactions and other clinical variables.

Results

HCC expressing high level of EpCAM showed more aggressively than usual progressed HCC. High EpCAM expression was associated with poor overall survival and recurrence free survival. (P=0.0005, 0.0019, respectively). A close association was found between tumoral EpCAM expression and peritumoral ductular reactions. Patients with high level of ductular reactions tended to have higher EpCAM expression than those with low level (P=0.016).

Conclusion

HCC stratification by EpCAM may reflect different prognosis. EpCAM expression correlated with ductular reactions may be a result of unregulated activation and differentiation blockage of progenitor cells.

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Introduction

Patients and methods

Patients and tissue samples

Follow-up and postoperative treatment

Immunohistochemical analysis of parafﬁn-embedded liver tissues

Statistical analysis

Results

Immunohistochemical characteristics

Quantitative EpCAM expression levels in HCC and DRs in non-tumor tissues

Correlation between EpCAM expression and clinicopathologic features in HCC

Expression of EpCAM expression with patients’ outcome

Association of EpCAM expression with tumor early recurrence

EpCAM expression and DRs in HCC

Discussion

Disclosure of interest

Esportazione

Vol 38 - N° 6

P. 699-705 - Dicembre 2014 Ritorno al numero

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Expression of epithelial cell adhesion molecule associated with elevated ductular reactions in hepatocellar carcinoma - 20/11/14

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Conclusion

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