Before the development of magnetic resonance imaging (MRI), evoked potentials (EPs)—visual evoked potentials, somatosensory evoked potentials, and brain stem auditory evoked responses—were commonly used to determine a second site of disease in patients being evaluated for possible multiple sclerosis (MS). The identification of an area of the central nervous system showing abnormal conduction was used to supplement the abnormal signs identified on the physical examination—thus identifying the “multiple” in MS. This article is a brief overview of additional ways in which central nervous system (CNS) physiology—as measured by EPs—can still contribute value in the management of MS in the era of MRIs.