Tumor Necrosis Factor-⍺ Gene Polymorphism Relationship to Seminal Variables in Infertile Men - 21/04/13
Reprint requests: Taymour Mostafa, M.D., Andrology and Sexology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.Abstract |
Objective |
To assess the tumor necrosis factor (TNF)-⍺ gene polymorphism relationship with seminal variables in fertile men (N) and those with asthenozoospermia (A), asthenoteratozoospermia (AT), and oligoasthenoteratozoospermia (OAT).
Materials and Methods |
A total of 50 infertile men without a female factor who were attending a fertility clinic and 48 fertile men were randomly screened for semen analysis, analysis of the TNF-⍺ promoter region for polymorphism, seminal caspase-9, acrosin activity, ⍺-glucosidase, and reproductive hormones.
Results |
The TNF-⍺ GG genotype was present in 83.9%, 72.7%, 66.7%, and 59.5%, the TNF-⍺ AA genotype in 3.2%, 6.8%, 10.4%, and 11.9%, and TNF-⍺ AG genotype in 12.9%, 20.5%, 22.9%, and 28.6% in the N, A, AT, OAT groups, respectively. The occurrence of A allele was significantly greater among infertile patients than among fertile controls (21.6% vs 9.7%; odds ratio 0.388, 95% confidence interval 0.2 to 0.75, P = .005). Men with the TNF-⍺ AA genotype demonstrated a significant decrease in the sperm count, sperm motility, normal sperm morphology, acrosin activity, and seminal ⍺-glucosidase and a significant increase in seminal caspase-9 compared with those with the TNF-⍺ GG genotype.
Conclusion |
This single nucleotide polymorphism in the TNF-⍺−308 gene was associated with significantly increased seminal caspase-9 and a significantly decreased sperm count, sperm motility, normal sperm morphology, acrosin activity, and seminal ⍺-glucosidase.
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| Financial Disclosure: The authors declare that they have no relevant financial interests. |
Vol 81 - N° 5
P. 962-966 - maggio 2013 Ritorno al numero
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