Efficacy of vitamins supplementation to therapy on Helicobacter pylori eradication in patients with low antioxidant capacity - 06/12/11
, Züleyha Akkan Çetinkaya a, Fatih Güzelbulut b, Hayrünnisa Sezikli c, Selvinaz Özkara d, Süleyman Coşgun b, Can Gönen b, Ayşe Oya Kurdaş Övünç b
Corresponding author. Tel.: +0902622335490-1695.Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
| pagine | 5 |
| Iconografia | 0 |
| Video | 0 |
| Altro | 0 |
Summary |
Background and objectives |
It was shown that supplementation of vitamins C and E to therapy increased Helicobacter pylori eradication rate. In the present study, we aimed to evaluate whether supplementation of antioxidant vitamins to therapy increases H. pylori eradication rates in patients with chronic stress and low antioxidant capacity.
Methods |
This study included 120 patients who presented to gastroenterology outpatient clinic with H. pylori-positive nonulcer dyspepsia and low total antioxidant capacity. Patients in group A (n=80) were given lansoprazole (30mg, BID), amoxicillin (1000mg, BID), and clarithromycin (500mg, BID) for 14 days, as well as vitamin C (500mg, BID) and vitamin E (200 IU, BID) for 30 days. Patients in group B (n=40) were given lansoprazole (30mg, BID), amoxicillin (1000mg, BID), and clarithromycin (500mg, BID) for 14 days.
Results |
Total antioxidant capacity were lower than normal levels in all patients. One hundred and fifteen patients (77 in group A, 38 in group B) were analyzed with per protocol analysis. In group A, H. pylori eradication was achieved in 63.8% of the patients included in the intention to treat analysis and in 66.2% of the patients included in the per protocol analysis. In group B, H. pylori eradication was achieved in 42.5% of the patients included in the intention to treat analysis and in 44.7% of the patients included in the per protocol analysis. Eradication rates were significantly higher in group A than in group B (P<0.005).
Conclusions |
Supplementation with vitamins C and E increased H. pylori eradication rate of standard triple therapy.
Il testo completo di questo articolo è disponibile in PDF.Mappa
Vol 35 - N° 11
P. 745-749 - Novembre 2011 Ritorno al numero
Articolo precedente
- Therapeutic strategies for severe alcoholic hepatitis
- Yoshinori Horie, Yoshiyuki Yamagishi, Hirotoshi Ebinuma, Toshifumi Hibi
- Dietary fiber in the diets of urban Tunisian women: Association of fiber intake with BMI, waist circumference and blood chemistry: Preliminary study
- Fethi Ben Slama, Nabila Jebali, Rachid Chemli, Chiheb Ben Rayana, Ahmed Achour, Mohamed Fadhl Najar, Noureddine Achour, Omrane Belhadj
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?