A metastatic case of gastrointestinal stromal tumor (GIST) treated with imatinib mesylate (Glivec®) in Mali - 18/10/11
, M. Ly a, G. Diallo b, A.K. Dembélé a, M. Touré c, B.A. Touré a, A. Koné a, S. Sidibé c, M. Dembelé d, B.C. Traore e
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Summary |
Gastrointestinal stromal tumors (GIST) usually showing a spindle cells pattern of cell proliferation have recently benefit from a molecular definition. Indeed imatinib mesylate (Gleevec®) treatment has dramatically improved the management of these tumors as they frequently express the c-kit oncogene. We report the first case of a metastatic gastric GIST in a man of 45 years diagnosed and treated in Mali. The gastric tumor was particularly aggressive with a large intra-abdominal and mesenteric spreading and liver metastases. The diagnosis was done on the CD117 and CD34 expression in the tumor sample obtained by laparotomy. After a 34 months 400mg/day imatinib mesylate (Gleevec®) treatment a dramatic tumor regression was obtained.
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Vol 35 - N° 10
P. 675-677 - Ottobre 2011 Ritorno al numero
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