Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: The respiratory tract as a paradigm - 04/09/11
Abstract |
Dendritic cells are now recognized as the gatekeepers of the immune response, possessing a unique potential for acquisition of antigens at extremely low exposure levels and for efficient presentation of these in an immunogenic form to the naive T-cell system. Dendritic cell populations throughout the body exhibit a wide range of features in common that are associated with their primary functions, and these are considered in the initial section of this review. In addition, it is becoming evident that the properties and functions of these cells are refined by microenvironmental factors unique to their tissues of residence, a prime example being mucosal microenvironments such as those in respiratory tract tissues, and the latter represents the focus of the second section of this review. (J Allergy Clin Immunol 2000;105:421-9.)
Il testo completo di questo articolo è disponibile in PDF.Keywords : Dendritic cells, immunoregulation, TH1/2, lung, T-cell activation, inflammation
Abbreviations : APC:, DC:, M-CSF:, MIIC:, NO:, RLN:, TH1/2:
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Reprint requests: P. G. Holt, DSc, FRCPath, Division of Cell Biology, TVW Telethon Institute for Child Health Research, PO Box 855, West Perth WA 6872, Australia. |
Vol 105 - N° 3
P. 421-429 - Marzo 2000 Ritorno al numeroBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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