Molecular mechanisms of IgE regulation - 04/09/11
Abstract |
IgE antibody plays an important role in allergic diseases. IgE synthesis by B cells requires two signals. The first signal is delivered by the cytokines IL-4 or IL-13, which target the Cϵ gene for switch recombination. The second signal is delivered by interaction of the B cell surface antigen CD40 with its ligand (CD40L) expressed on activated T cells. This activates deletional switch recombination. We review the molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype switching and discuss the implications for intervening to abort or suppress the IgE antibody response. (J Allergy Clin Immunol 2000;105:S547-58.)
Il testo completo di questo articolo è disponibile in PDF.Keywords : IgE, isotype switching, interleukins
Abbreviations : CD40L, DNA-PK, GLT, IRS-1, JAK, NF-κB, PI-3K, RAG, SHP-1, STAT, TCR, TRAF
Mappa
 | Supported by NIH grants AI-31136, AI-35714, AI-31541, T32 (Training Grant) AI-07512, and by grants from Baxter, Alpha Therapeutics, and Olsten Corporations. |
| Reprint requests: Raif S. Geha, MD, Children’s Hospital, Division of Immunology, 300 Longwood Ave, Enders 8, Boston, MA 02115. E-mail: geha@A1.tch.harvard.edu |
 | 0091-6749/2000 $12.00 + 0 1/0/99521 |
Vol 105 - N° 2P2
P. S547-S558 - Febbraio 2000 Ritorno al numero
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