The Family Atherosclerosis Monitoring In earLY life (FAMILY) study : Rationale, design, and baseline data of a study examining the early determinants of atherosclerosis - 12/08/11
, Stephanie A. Atkinson, RD, PhD a, Salim Yusuf, MD, DPhil, FRCPC b, e, Jacqueline Bourgeois, MD, FRCPC c, Sarah McDonald, MD, FRCPC d, Matthew J. McQueen, MBChB, PhD, FCACB, FRCPC c, Richard Persadie, MD, FRCPC f, Barry Hunter, MD, FRCPC g, Janice Pogue, PhD e, Koon Teo, MBBCH, PhD, FRCPC b, ethe FAMILY investigators
Riassunto |
Background |
Complex interactions among genetic, epigenetic, and environmental exposures, further modified by a child's postnatal environment, underlie the relationship among maternal health, fetal growth, and the development of cardiovascular disease (CVD) risk factors in the child and disease in the adult. Few available studies consider the genetic and environmental influences of the family, beyond maternal health. The purpose of this study is to examine the fetal and early childhood family-based determinants for the development of adiposity, CVD risk factors, and atherosclerosis in childhood.
Method |
A cohort of 850 children and their families (mother, father, eldest sibling) are being recruited during pregnancy to a prospective longitudinal study to investigate the relative contribution of (a) prenatal and postnatal determinants and (b) individual and family (maternal/paternal) determinants for the development of adiposity and CVD risk factors at 3, 5, and 10 years of age and carotid intima media thickness at 10 years.
Implications |
The FAMILY study will advance understanding of the fetal and early childhood determinants for CVD development and will contribute to the design of primary prevention programs based on identification of the most important modifiable determinants for early childhood adiposity and CVD risk factor development.
Il testo completo di questo articolo è disponibile in PDF.Mappa
Vol 158 - N° 4
P. 533-539 - Ottobre 2009 Ritorno al numero
Articolo precedente
- Design and rationale of the TRI-stent Adjudication Study (TRIAS) Program
- Margo Klomp, Marcel A.M. Beijk, Niels J.W. Verouden, Jan G.P. Tijssen, Robbert J. de Winter, on behalf of all TRIAS Investigators a
- Differential effects of afterload on left ventricular long- and short-axis function: Insights from a clinical model of patients with aortic valve stenosis undergoing aortic valve replacement
- Shemy Carasso, Oved Cohen, Diab Mutlak, Zvi Adler, Jonathan Lessick, Shimon A. Reisner, Harry Rakowski, Gil Bolotin, Yoram Agmon
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?