Multiple sclerosis is a chronic, debilitating, inflammatory, and neurodegenerative disease of the central nervous system. There is no cure for the disease, and its management includes use of symptomatic agents and diseasemodifying therapies to reduce and/or prevent relapses and disease progression. Fatigue affects up to 90% of MS patients and can significantly impair function, quality of life, and interaction with family and friends. The common causes of fatigue and effective interventions and treatments are reviewed in this article.