Epidural steroid injection (ESI) has been used to treat cervical radiculopathy for several decades. Generally, available studies demonstrate favorable results, although definitive evidence of efficacy is lacking. ESIs are not considered a first line treatment and are undertaken after non-interventional treatments have been adequately provided. In the cervical spine, where evidence of potential benefit is moderate and there is risk of major complication, non-interventional care is even more germane. This article reviews the available literature regarding risks and efficacy of ESIs for cervical radiculopathy, and aims to guide practitioners in treatment decisions for individual patients.