Acute liver failure in children - 14/06/11

Doi : 10.1016/j.clinre.2011.03.005

Denis Devictor ^a,^⁎ , Pierre Tissieres ^a, Mickael Afanetti ^a, Dominique Debray ^b
^a Neonatal, Pediatric Intensive Care Unit, Department of Pediatrics, AP–HP, Bicêtre Hospital, Paris 11-Sud University, 78, avenue Général-Leclerc, 94275 Le Kremlin-Bicêtre, France
^b Pediatric Hepatology, AP–HP, Necker–Enfants-malades Hospital, 75015 Paris, France

Corresponding author. Tel.: +33 1 45 21 32 05; fax: +33 1 45 21 28 58.

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Summary

The management of children with acute liver failure mandates a multidisciplinary approach and intense monitoring. In recent years, considerable progress has been made in developing specific and supportive medical measures, but clinical studies have mainly concerned adult patients. There are no specific medical therapies, except for a few metabolic diseases presenting with acute liver failure. Liver transplantation still remains the only definitive therapy in most instances. Recent clinical studies suggest that hepatocyte transplantation may be useful for bridging patients to liver transplantation, for providing metabolic support during liver failure and for replacing liver transplantation in certain metabolic liver diseases.

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