Moderate forms of 21-hydroxylase deficiency (D21OH-NC), the so-called non-classical or late-onset forms are a frequently reported cause of hyperandrogenism in women [1New M.I. Extensive clinical experience: nonclassical 21-hydroxylase deficiency J Clin Endocrinol Metab 2006 ;  91 : 4205-4214[Erratum in: J Clin Endocrinol Metab 2007;92:142].  [cross-ref]

Cliccare qui per andare alla sezione Riferimenti, 2Kuttenn F., Couillin P., Girard F., Billaud L., Vincens M., Boucekkine C., e al. Late-onset adrenal hyperplasia in hirsutism N Engl J Med 1985 ;  313 : 224-231 [cross-ref]

Cliccare qui per andare alla sezione Riferimenti, 3Azziz R., Woods K.S., Reyna R., Key T.J., Knochenhauer E.S., Yildiz B.O. The prevalence and features of the polycystic ovary syndrome in an unselected population J Clin Endocrinol Metab 2004 ;  89 : 2745-2749 [cross-ref]

Cliccare qui per andare alla sezione Riferimenti, 4Escobar-Morreale H.F., Sanchón R., San Millán J.L. A prospective study of the prevalence of nonclassical congenital adrenal hyperplasia among women presenting with hyperandrogenic symptoms and signs J Clin Endocrinol Metab 2008 ;  93 : 527-533 [cross-ref]

Cliccare qui per andare alla sezione Riferimenti, 5Carmina E., Rosato F., Jannì A., Rizzo M., Longo R.A. Extensive clinical experience: relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism J Clin Endocrinol Metab 2006 ;  91 : 2-6 [cross-ref]

Cliccare qui per andare alla sezione Riferimenti]. The purpose of this collective and synthetic work was to provide the endocrinologist, gynecologist and dermatologist with consensual information so as to detect the maximum cases with acceptable cost–benefit ratio and to define the main lines of optimal patient management, given the data currently available in medical literature.