Herbal medicine is commonly practiced in Morocco, but the use of toxic plants, whether accidental or intentional, poses significant health risks. This case report discusses fatal hepatotoxicity in a 12-year-old child following the ingestion of Globularia alypum (“Ghafour”) and Rubia tinctorum (“Foua”), which are frequently used in traditional remedies. The remedies were administered before the initial hospital admission. The patient, with no prior medical history, presented with jaundice and ascitic syndrome. After leaving the hospital against medical advice, his condition worsened following repeated ingestion of these plants. Readmitted 29 days later with severe hepatic encephalopathy and multi-organ dysfunction. Despite aggressive medical intervention, the patient succumbed to complications of severe liver and renal toxicity. The toxic effects of Globularia alypum were linked to iridoid glycosides, leading to oxidative stress, hepatocellular damage, and cholestasis, while Rubia tinctorum contributed to renal damage through its content. This case highlights the critical need for public education on the dangers of traditional herbal treatments, particularly those involving toxic plants, and underscores the importance of early medical intervention in such poisonings.