Parkinson’s disease, multiple sclerosis, and Alzheimer’s disease are 3 prevalent neurodegenerative diseases. Beyond disparate disease incidences between men and women, additional sex-related differences exist. Disease presentation, natural course, treatment considerations, genetic factors, hormonal factors, health care utilization patterns, and outcomes can vary between men and women in general. These disease processes represent examples of well-defined discrepancies between men and women afflicted. Other neurodegenerative conditions, such as motor neuron disorders, progressive supranuclear palsy, and multisystem atrophy, have shown to have a slight predilection toward men compared to women, yet have not been as extensively studied.