Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer’s Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study - 21/11/24
, L. Sarasa 1, I. Monleón 1, I. San-José 1, J. Arbizu 2, P. Martínez-Lage 3, J. Munuera 4, A. Ruiz 5, L. Tárraga 5, M. Boada 5, M. Sarasa 1, 6The AB255 Study Group
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Abstract |
Background |
Easily accessible biomarkers are needed for the early identification of individuals at risk of developing Alzheimer’s disease (AD) in large population screening strategies.
Objectives |
This study evaluated the potential of plasma β-amyloid (Aβ) biomarkers in identifying early stages of AD and predicting cognitive decline over the following two years.
Design |
Total plasma Aβ42/40 ratio (TP42/40) was determined in 83 cognitively normal individuals (CN) and 145 subjects with amnestic mild cognitive impairment (a-MCI) stratified by an FDG-PET AD-risk pattern.
Results |
Significant lower TP42/40 ratio was found in a-MCI patients compared to CN. Moreover, a-MCIs with a highrisk FDG-PET pattern for AD showed even lower plasma ratio levels. Low TP42/40 at baseline increased the risk of progression to dementia by 70%. Furthermore, TP42/40 was inversely associated with neocortical amyloid deposition (measured with PiB-PET) and was concordant with the AD biomarker profile in cerebrospinal fluid (CSF).
Conclusions |
TP42/40 demonstrated value in the identification of individuals suffering a-MCI, in the prediction of progression to dementia, and in the detection of underlying AD pathology revealed by FDG-PET, Amyloid-PET and CSF biomarkers, being, thus, consistently associated with all the well-established indicators of AD.
Il testo completo di questo articolo è disponibile in PDF.Key words : β-amyloid (Aβ), Alzheimer’s disease, plasma, biomarker, Aβ ratio
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Vol 6 - N° 1
P. 34-41 - Gennaio 2019 Ritorno al numero
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