Analysis of the Relationship of Cognitive Impairment and Functional Impairment in Mild Alzheimer’s Disease in EXPEDITION 3 - 21/11/24
, E. Siemers 1, K. Sundell 1, M. Mynderse 2, J. Cummings 3, R. Mohs 4, P. Aisen 5
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Abstract |
Background |
Clinical progression of Alzheimer’s disease is characterized by impairment in cognition and function.
Objective |
To assess the relationship between cognitive and functional impairment in mild Alzheimer’s disease.
Design |
Spearman’s rank correlations between cognitive and functional measures were calculated. Autoregressive cross-lagged panel analyses were used to determine the temporal relationship between cognitive and functional decline.
Setting |
Post-hoc analysis of clinical trial data.
Participants |
Placebo-treated patients with mild Alzheimer’s disease from the Phase 3 solanezumab study EXPEDITION 3.
Intervention |
Placebo.
Measurements |
Cognitive and functional measures were assessed at baseline and at six post-baseline time points through Week 80.
Results |
Correlation between cognitive and functional measures was 0.41 at baseline and 0.65 at Week 80. Autoregressive cross-lagged panel analysis demonstrated that cognitive impairment preceded and predicted subsequent functional decline, but functional scores did not predict cognitive outcomes.
Conclusions |
This study supports the hypothesis that functional impairment predictably follows cognitive decline in mild Alzheimer’s disease dementia.
Il testo completo di questo articolo è disponibile in PDF.Key words : Cognition, function, Alzheimer’s disease, correlation
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Vol 5 - N° 3
P. 184-187 - Luglio 2018 Ritorno al numero
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