Cerca
image du produit
The Journal of Prevention of Alzheimer's Disease

Modifiable Risk Factors for Accelerated Decline in Processing Speed: Results from Three Dutch Population Cohorts - 21/11/24

Doi : 10.14283/jpad.2023.64 
E. Jaarsma 1, 2, 3, A. Nooyens 1, Almar A.L. Kok 2, 3, 4, 10, ⁎ , S. Köhler 5, 6, 7, M. van Boxtel 5, 6, 7, W.M.M. Verschuren 1, 8, M. Huisman 2, 3, 9
1 Center for Nutrition, Prevention, and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands 
2 Amsterdam UMC location Vrije Universiteit Amsterdam, Epidemiology and Data Science, De Boelelaan 1117, Amsterdam, Netherlands 
3 Amsterdam Public Health, Aging and Later Life, Amsterdam, the Netherlands 
4 Department of Psychiatry, Amsterdam Public Health, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands 
5 School for Mental Health & Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands 
6 Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands 
7 Alzheimer Centrum Limburg, Maastricht University Medical Center+, Maastricht, the Netherlands 
8 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands 
9 Department of Sociology, Faculty of Social Sciences, Vrije Universiteit, Amsterdam, the Netherlands 
10 Amsterdam UMC Locatie De Boelelaan: Amsterdam UMC Locatie VUmc, Amsterdam, the Netherlands 

c a.kok1@amsterdamumc.nl a.kok1@amsterdamumc.nl
connettersi o creare un account

Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
Articolo gratuito.

Si connetta per beneficiarne

Abstract

Background

Several lifestyle, cardiovascular and psychosocial factors are associated with risk of cognitive decline and dementia. We studied the independent associations of a broad set of modifiable risk factors with decline in processing speed in three large population-based cohorts with up to 23 years of follow-up.

Methods

We used data of 9,666 participants from the Doetinchem Cohort Study, the Longitudinal Aging Study Amsterdam, and the Maastricht Aging Study. Decline in processing speed was measured with the letter digit substitution task or the alphabet coding task and modeled using quadratic latent growth curves. Associations of modifiable risk factors with level and rate of decline in processing speed were investigated by estimating associations with level of processing speed at different centering ages.

Results

Latent growth curves showed that decline in processing speed accelerated with age. Smoking, not drinking alcohol and depressive symptoms were associated with a lower level of processing speed in all cohorts. In two of the cohorts, more physical activity, drinking more than two glasses of alcohol per day, higher BMI and diabetes were associated with a lower level of processing speed. Depressive symptoms and diabetes were also associated with faster decline in processing speed.

Conclusion

Several modifiable risk factors are associated with the level of processing speed in older age, while few are also related to the rate of decline.

Il testo completo di questo articolo è disponibile in PDF.

Key words : Cognitive decline, risk factors, processing speed, general population


Mappa


© 2023  THE AUTHORS. Published by Elsevier Masson SAS on behalf of SERDI Publisher.. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
Aggiungere alla mia biblioteca Togliere dalla mia biblioteca Stampare
Esportazione

    Citazioni Export

  • File

    •

  • Contenuto

    •

Vol 11 - N° 1

P. 108-116 - Gennaio 2024 Ritorno al numero
Articolo precedente Articolo precedente
  • Burden of Illness in People with Alzheimer’s Disease: A Systematic Review of Epidemiology, Comorbidities and Mortality
  • Krista L. Lanctôt, J. Hviid Hahn-Pedersen, C.S. Eichinger, C. Freeman, A. Clark, L.R.S. Tarazona, J. Cummings
| Articolo seguente Articolo seguente
  • Relationships of Hypnotics with Incident Dementia and Alzheimer’s Disease: A Longitudinal Study and Meta-Analysis
  • J.-H. Hou, S.-L. Sun, C.-C. Tan, Y.-M. Huang, L. Tan, Alzheimer’s Disease Neuroimaging Initiative, Wei Xu

Benvenuto su EM|consulte, il riferimento dei professionisti della salute.

Il mio account

Aide & support

Dichiarazione CNIL

EM-CONSULTE.COM è registrato presso la CNIL, dichiarazione n. 1286925.

Ai sensi della legge n. 78-17 del 6 gennaio 1978 sull'informatica, sui file e sulle libertà, Lei puo' esercitare i diritti di opposizione (art.26 della legge), di accesso (art.34 a 38 Legge), e di rettifica (art.36 della legge) per i dati che La riguardano. Lei puo' cosi chiedere che siano rettificati, compeltati, chiariti, aggiornati o cancellati i suoi dati personali inesati, incompleti, equivoci, obsoleti o la cui raccolta o di uso o di conservazione sono vietati.
Le informazioni relative ai visitatori del nostro sito, compresa la loro identità, sono confidenziali.
Il responsabile del sito si impegna sull'onore a rispettare le condizioni legali di confidenzialità applicabili in Francia e a non divulgare tali informazioni a terzi.

Tutto il contenuto di questo sito: Copyright © 2024 Elsevier, i suoi licenziatari e contributori. Tutti i diritti sono riservati. Inclusi diritti per estrazione di testo e di dati, addestramento dell’intelligenza artificiale, e tecnologie simili. Per tutto il contenuto ‘open access’ sono applicati i termini della licenza Creative Commons.