Optimization of endoscopic treatment strategies for R0 resection of rectal neuroendocrine tumors smaller than 10 mm - 02/10/24
, Jianqiang Liu a, b, ⁎ Highlights |
• | Accidental diagnostic biopsy by cold forceps with regular follow-ups and without further secondary resection could be considered as the possible treatment for 2 - 3 mm rectal neuroendocrine tumor. |
• | For patients with ≤ 10 mm rectal neuroendocrine tumors, both EMR and ESD could be used as sufficient therapy. |
Abstract |
Background |
The optimal histologically complete (R0) resection methods of endoscopy for rectal neuroendocrine tumor (NET) ≤ 10 mm remains controversial. We aimed to assess the optimal endoscopic treatments for NETs.
Methods |
The retrospective enrolled patients (n = 208) with rectal NETs were divided into 3 subsets according to pathological tumor size: 2 - 3 mm, 4 - 5 mm, and 6 - 10 mm NETs. Factors associated with R0 resection according to different endoscopic treatments (accidental diagnostic biopsy by cold forceps, endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD)) and tumor size were investigated. All patients underwent follow-up and no local recurrence or metastasis were identified.
Results |
A total of 208 patients were enrolled. In patients with 2 - 3 mm NETs, the R0 resection rate was 100.0 % for biopsy, EMR, and ESD. The R0 resection rate for biopsy of 4 - 5 mm and 6 - 10 mm NETs was 34.3 % and 0.0 % respectively, which was inferior to the EMR/ESD rate (4 - 5mm: p < 0.001; 6 - 10 mm: p < 0.001: respectively). For patients with ≤ 10 mm NETs, EMR and ESD had a comparable en bloc (p = 0.082) and R0 resection rates (p = 0.651).
Conclusion |
Accidental diagnostic biopsy by cold forceps could be considered as the possible treatment for 2 - 3 mm rectal NETs. And for patients with ≤ 10 mm rectal NETs, both EMR and ESD might be sufficient.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Rectal neuroendocrine tumor, Accidental diagnostic biopsy, Endoscopic submucosal dissection, Endoscopic mucosal resection
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Vol 48 - N° 9
Articolo 102469- Novembre 2024 Ritorno al numero
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