Impact of the clinical frailty scale on long-term outcomes after transcatheter aortic valve implantation - 16/08/24
, Shinichi Shirai, MD a, Katsunori Miyahara, MD a, Ko Yamamoto, MD, PhD a, Tomohiro Suenaga, MD a, Akira Otani, MD, PhD a, Kenji Nakano, MD a, Tadatomo Fukushima, MD a, Euihong Ko, MD a, Yasuo Tsuru, MD a, Miho Nakamura, MD a, Toru Morofuji, MD a, Takashi Morinaga, MD a, Masaomi Hayashi, MD a, Akihiro Isotani, MD a, Nobuhisa Ohno, MD b, Shinichi Kakumoto, MD c, Kenji Ando, MD aABSTRACT |
Background |
The semiquantitative Clinical Frailty Scale (CFS) is reportedly a useful marker for predicting short- and mid-term mortality after transcatheter aortic valve implantation (TAVI). We assessed the long-term prognostic impact of CFS in patients with severe aortic stenosis undergoing TAVI.
Methods |
We prospectively assessed patients undergoing TAVI in Kokura Memorial Hospital using a 9-level CFS and enrolled 1594 patients after excluding patients with CFS 8-9. The patients were divided into the low (CFS level, 1-3; N = 842), intermediate (4; N = 469), and high (5-7; N = 283) groups according to their CFS levels.
Results |
In the low, intermediate, and high groups, 3-year all-cause mortality rates were 17.4%, 29.4%, and 41.7% (P < .001) and composite rates of cardiovascular mortality and heart failure hospitalization were 12.1%, 19.1%, and 23.9% (P < .001), respectively. Multivariable analysis showed that higher frailty was independently associated with all-cause mortality (intermediate group: adjusted hazard ratio [HR], 1.63, 95% confidence interval [CI], 1.24-2.15, P < .001; high group: adjusted HR, 2.18, 95% CI, 1.59-2.99, P < .001) and composite of cardiovascular mortality and heart failure hospitalization (intermediate group: adjusted HR, 1.47, 95% CI, 1.04-2.08, P = .030; high group: adjusted HR, 1.66, 95% CI, 1.09-2.51, P = .018) and this result was consistent, irrespective of stratification based on age, sex, body mass index, left ventricular ejection fraction, Society of Thoracic Surgeons score, and New York Heart Association functional class without significant interaction.
Conclusions |
The simple CFS tool predicts the long-term adverse outcomes post-TAVI.
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Vol 275
P. 141-150 - Settembre 2024 Ritorno al numero
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