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Strong association between sarcopenic obesity and non-alcoholic fatty liver disease: An observational study with ISarcoPRM algorithm - 15/07/24

Doi : 10.1016/j.clinre.2024.102412 
Selim Demirci a, , Semih Sezer a, Kübra Erdoğan b, Ahmad J Abdulsalam c, Özgür Kara b, Murat Kara c
a Department of Internal Medicine, Divisions of Gastroenterology, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkiye 
b Department of Internal Medicine, Divisions of Geriatric Medicine, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkiye 
c Department of Physical and Rehabilitation Medicine,Hacettepe University Medical School, Ankara, Turkiye 

Corresponding author at: Department of Internal Medicine, Divisions of Gastroenterology, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkiye.Department of Internal MedicineDivisions of GastroenterologyDr. Abdurrahman Yurtaslan Oncology Training and Research HospitalAnkaraTurkiye

Highlights

Sarcopenia is not a risk factor for non-alcoholic fatty liver disease in the elderly.
Sarcopenic obesity is strongly associated with non-alcoholic fatty liver disease.
To protect non-alcoholic fatty liver disease, older females should exercise regularly.
Sarcopenia diagnosis can be establish through anterior thigh muscle ultrasonography.

Il testo completo di questo articolo è disponibile in PDF.

Abstract

Background

In recent times, sarcopenia and non-alcoholic fatty liver disease (NAFLD) have garnered widespread attention in public health. Nevertheless, the relationship between sarcopenia and NAFLD remains uncertain. This study investigated the association between NAFLD and sarcopenia in the elderly population.

Methods

In this cross-sectional study, 1099 adults aged 60 and older participated. The participants were classified based on their body composition, and the International Society of Physical and Rehabilitation Medicine's diagnostic algorithm (ISarcoPRM) was utilized to diagnose sarcopenia, while the fatty liver index was utilized to diagnose NAFLD. Binary logistic regression analysis determined the correlation between NAFLD and sarcopenia.

Results

Of the 1099 participants, 213 (58.2 %) males and 480 (65.5 %) females were afflicted with NAFLD. After adjusting for other clinical factors, exercise was found to decrease the likelihood of NAFLD in females (but not in males) by approximately 70 % [relative risk (RR): 0.312, 95 % confidence interval (CI): 0.182–0.547]. In addition, sarcopenia was not discerned as a risk factor for NAFLD in either gender (both p > 0.05). However, obesity increased the likelihood of NAFLD in males by 27.5 (95 % CI: 10.4–73.1) and in females by 28.1 (95 % CI: 17.1–46.4), and sarcopenic obesity increased the likelihood of NAFLD by 49.5 (95 % CI: 11.1–219.1) in males and 35.5 (95 % CI: 18.5–68.2) in females (all p < 0.001).

Conclusion

Our study suggests that sarcopenia is not a risk factor for NAFLD in non-obese elderly subjects. However, a strong association was observed between obesity, especially sarcopenic obesity, and NAFLD. Regular physical activity seems protective for NAFLD in older females.

Il testo completo di questo articolo è disponibile in PDF.

Keywords : Ultrasound, Sarcopenia, Quadriceps, Grip strength, Body composition


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Vol 48 - N° 7

Articolo 102412- Agosto 2024 Ritorno al numero
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