Metabolism-related signalling pathways involved in the pathogenesis and development of metabolic dysfunction-associated steatotic liver disease - 07/02/24
Doi : 10.1016/j.clinre.2023.102264
Cheng Xie 
, Kaiyu Liu , Yixin Xie , Shun Liu , Bai Ji ⁎
, Kaiyu Liu , Yixin Xie , Shun Liu , Bai Ji ⁎ Department of Hepatobiliary and Pancreatic Surgery, General Surgery Centre, First Hospital of Jilin University, 1 XinMin St., Changchun, Jilin, China
⁎Corresponding author.
Highlights |
• | Many current studies have revealed a variety of different metabolism-related signalling pathways that affect the occurrence and development of metabolic dysfunction-associated steatotic liver disease (MASLD). |
• | Recently, non-alcoholic fatty liver disease (NAFLD) was renamed MASLD by experts and patients in a multisociety Delphi consensus statement. |
• | In the future, we can develop some effective targeted drugs at the level of metabolism-related signalling pathways to intervene in the progression of MASLD into liver cancer. |
Abstract |
Metabolic dysfunction-associated steatotic liver disease (MASLD) which formerly known as non-alcoholic fatty liver disease (NAFLD) is one of the causes of liver cirrhosis. Currently, a growing number of liver cirrhosis cases develop on the basis of MASLD, and the pathogenesis of MASLD remains unclear. This paper reviews the research progress on the involvement of different metabolism-related signalling pathways in the pathogenesis and development of MASLD.
Il testo completo di questo articolo è disponibile in PDF.Keywords : MASLD, NAFLD, Pathogenesis, Signalling pathway, Metabolism
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© 2023
The Authors. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
Vol 48 - N° 2
Articolo 102264- Febbraio 2024 Ritorno al numero
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