The SARS-CoV-2 pandemic and asthma: What we have learned and what is still unknown - 07/12/23
, Kateryna Yevdokimova, MD ∗, Linda Rogers, MD, Monica Kraft, MD
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Abstract |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has brought new insights into the immunologic intricacies of asthma. In this review, we discuss the epidemiology of asthma in patients infected with SARS-CoV-2 and the risk of severe infection. Type 2 inflammation had an overall protective effect against SARS-CoV-2 infection by various mechanisms summarized in this review. Asthma, intranasal, and inhaled corticosteroids decreased the angiotensin-converting enzyme 2 receptor, an important receptor for SARS-CoV-2 entry into host cells. We summarize the nuances of the treatment of type 2 inflammation despite its underlying protective effects. Research to date has shown that patients on various allergen immunotherapies and biologics do benefit from being vaccinated.
Il testo completo di questo articolo è disponibile in PDF.Key words : Asthma, COVID-19, type 2 inflammation, ACE2 receptor, biologic, allergen immunotherapy, antiviral mechanisms, exacerbations, vaccine, immunophenotyping assessment of COVID-19
Abbreviations used : ACE2, AIT, ICS, ILC2, pDC, SARS-CoV-2, TLR, TMPRSS2
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Vol 152 - N° 6
P. 1376-1381 - Dicembre 2023 Ritorno al numero
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