Impact of ovarian diseases on fertility reserve as assessed through serum AMH levels in reproductive age women - 30/11/23
, Shubhangi Srivastava a , Nidhi Singh b, ⁎ , Wahid Ali c
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Highlights |
• | This paper has compared Serum AMH between benign ovarian diseases, endmetriomas and ovarian malignancy to assess their effect on fertility reserve. |
• | S. AMH levels were found to be significantly lower in malignant ovarian tumours. |
• | Compared to benign ovarian diseases S. AMH levels were significantly lower in endometriosis indicating adverse effect of endometriosis on ovarian reserve. |
• | There was an inverse and statistically significant correlation in mean S. AMH levels with CA-125 levels as well (p = 0.042). |
Abstract |
Aims and objectives |
The aim of this study was to assess the effect of ovarian diseases on fertility reserve evaluating serum Anti-Mullerian Hormone (AMH) levels.
Materials and methods |
This was a prospective study conducted on 66 reproductive age patients operated for an ovarian mass in the Department of Obstetrics and Gynaecology of a tertiary care teaching hospital in North India. The study included n = 18 cases of ovarian cancer, n = 20 cases of endometrioma and n = 28 cases of other benign ovarian disease. 5 ml of venous blood sample was obtained prior to surgical intervention for serum AMH analysis. Fertility sparing surgeries were done in n = 48 cases and n = 18 cases underwent radical surgeries. Histopathology (HPE) reports were recorded for all cases post-surgery. Serum AMH was correlated with HPE report to see the effect of various ovarian diseases on fertility status.
Result |
Serum AMH levels in malignant (0.34 ± 0.44 ng/mL) and endometrioma cases (1.50 ± 0.62 ng/mL) were significantly lower (p < 0.05) as compared to those found in cases affected by other inflammatory/benign cyst (3.93 ± 4.76 ng/mL). Ovarian cancer cases had the lowest serum AMH value (0.34 ± 0.44 ng/mL), well below the normal range.
Conclusion |
Ovarian cancer has an important adverse effect on ovarian fertility reserve, greater than endometriomas. Other benign ovarian tumors do not affect fertility reserve.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Anti-müllerian hormone, Benign ovarian tumor, Endometrioma, Laparoscopic cystectomy, Malignant ovarian tumor, Ovarian reserve
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Articolo 100051- Dicembre 2023 Ritorno al numero
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