Time varying analysis of dynamic resting-state functional brain network to unfold memory function - 27/11/23
Abstract |
Recent advances in brain network analysis are largely based on graph theory methods to assess brain network organization, function, and malfunction. Although, functional magnetic resonance imaging (fMRI) has been frequently used to study brain activity, however, the nonlinear dynamics in resting-state (fMRI) data have not been extensively characterized. In this work, we aim to model the dynamics of resting-state (fMRI) and characterize the dynamical patterns in resting-state (fMRI) time series data in left and right hippocampus and inferior frontal gyrus. We use Sliding Window Embedding (SWE) method to reconstruct the phase space of resting-state (fMRI) data from left and right hippocampus and orbital part of inferior frontal gyrus. The complexity of resting-state MRI data is examined using fractal analysis. The main purpose of the current study is to explore the topological organization of hippocampus and frontal gyrus and consequently, memory. By constructing resting-state functional network from resting-state (fMRI) time series data, we are able to draw a big picture of how brain functions and step forward to classify brain activity between normal control people and patients with different brain disorders.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Resting-state functional MRI (rsfMRI) has been used frequently in studying brain normal and abnormal functionality. |
• | This study furnishes neuroscience research with a new perspective for detecting altered topological structure, geometry and complexity of rsfMRI. |
• | We use Sliding Window Embedding (SWE) to describe geometrical and topological properties (to capture the dynamics) of sliding window. |
• | The fractal geometry quantifies the variation in geometry and dimensional complexity of the rsfMRI and as a potential diagnostic tool for clinical decision making. |
• | The ultimate goal is dynamic analysis of rsfMRI to improve our understanding of normal cognition and changes in dynamic brain connectivity. |
Keywords : Dynamic memory, Topological data analysis, Sliding window embedding, Resting state networks, Hippocampus, Frontal gyrus
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Vol 4 - N° 1
Articolo 100148- Marzo 2024 Ritorno al numeroBenvenuto su EM|consulte, il riferimento dei professionisti della salute.